| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5604 |
Name | MAP2K1 |
Synonym | CFC3|MAPKK1|MEK1|MKK1|PRKMK1;mitogen-activated protein kinase kinase 1;MAP2K1;mitogen-activated protein kinase kinase 1 |
Definition | ERK activator kinase 1|MAPK/ERK kinase 1|MAPKK 1|MEK 1|dual specificity mitogen-activated protein kinase kinase 1|protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1) |
Position | 15q22.1-q22.33 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | il-2 receptor beta chain in t cell activation;PID BioCarta;100129 |
Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | role of erbb2 in signal transduction and oncology;PID BioCarta;100147 |
Pathway | Signaling by Insulin receptor;Reactome;REACT:498 |
Pathway | ccr3 signaling in eosinophils;PID BioCarta;100215 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | pdgf signaling pathway;PID BioCarta;100077 |
Pathway | sprouty regulation of tyrosine kinase signals;PID BioCarta;100029 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | Melanogenesis;KEGG PATHWAY;hsa04916 |
Pathway | Signaling by EGFR;Reactome;REACT:9417 |
Pathway | EPHB forward signaling;PID Curated;200041 |
Pathway | ras-independent pathway in nk cell-mediated cytotoxicity;PID BioCarta;100095 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | egf signaling pathway;PID BioCarta;100181 |
Pathway | aspirin blocks signaling pathway involved in platelet activation;PID BioCarta;100030 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | regulation of splicing through sam68;PID BioCarta;100036 |
Pathway | IFN-gamma pathway;PID Curated;200110 |
Pathway | inhibition of cellular proliferation by gleevec;PID BioCarta;100154 |
Pathway | Hedgehog signaling events mediated by Gli proteins;PID Curated;200147 |
Pathway | Endothelins;PID Curated;200004 |
Pathway | Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | bcr signaling pathway;PID BioCarta;100227 |
Pathway | erk1/erk2 mapk signaling pathway;PID BioCarta;100170 |
Pathway | Bladder cancer;KEGG PATHWAY;hsa05219 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | tpo signaling pathway;PID BioCarta;100012 |
Pathway | mcalpain and friends in cell motility;PID BioCarta;100111 |
Pathway | Long-term depression;KEGG PATHWAY;hsa04730 |
Pathway | Oocyte meiosis;KEGG PATHWAY;hsa04114 |
Pathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy;PID BioCarta;100221 |
Pathway | Ras signaling in the CD4+ TCR pathway;PID Curated;200088 |
Pathway | ErbB2/ErbB3 signaling events;PID Curated;200119 |
Pathway | signaling pathway from g-protein families;PID BioCarta;100153 |
Pathway | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade;PANTHER;P00032 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | Signaling by PDGF;Reactome;REACT:16888 |
Pathway | human cytomegalovirus and map kinase pathways;PID BioCarta;100149 |
Pathway | mapkinase signaling pathway;PID BioCarta;100113 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | CXCR3-mediated signaling events;PID Curated;200150 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | Downstream signaling in naive CD8+ T cells;PID Curated;200184 |
Pathway | Trk receptor signaling mediated by the MAPK pathway;PID Curated;200182 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | role of beta-arrestins in the activation and targeting of map kinases;PID BioCarta;100229 |
Pathway | phospholipids as signalling intermediaries;PID BioCarta;100183 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Thyroid cancer;KEGG PATHWAY;hsa05216 |
Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | ceramide signaling pathway;PID BioCarta;100206 |
Pathway | influence of ras and rho proteins on g1 to s transition;PID BioCarta;100054 |
Pathway | melanocyte development and pigmentation pathway;PID BioCarta;100108 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | anthrax toxin mechanism of action;PID BioCarta;100242 |
Pathway | tgf beta signaling pathway;PID BioCarta;100017 |
Pathway | fmlp induced chemokine gene expression in hmc-1 cells;PID BioCarta;100162 |
Pathway | trefoil factors initiate mucosal healing;PID BioCarta;100018 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Nongenotropic Androgen signaling;PID Curated;200145 |
Pathway | Ras Pathway;PANTHER;P04393 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Long-term potentiation;KEGG PATHWAY;hsa04720 |
Pathway | keratinocyte differentiation;PID BioCarta;100119 |
Pathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling;PID BioCarta;100236 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | Class IB PI3K non-lipid kinase events;PID Curated;200081 |
Pathway | Renal cell carcinoma;KEGG PATHWAY;hsa05211 |
Pathway | nerve growth factor pathway (ngf);PID BioCarta;100096 |
Pathway | Prion diseases;KEGG PATHWAY;hsa05020 |
Pathway | role of mal in rho-mediated activation of srf;PID BioCarta;100114 |
Pathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia;PID BioCarta;100184 |
Pathway | Ceramide signaling pathway;PID Curated;200100 |
Pathway | phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway;PID BioCarta;100210 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Pathway | GMCSF-mediated signaling events;PID Curated;200015 |
Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | igf-1 signaling pathway;PID BioCarta;100136 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | RAF phosphorylates MEK;PID Reactome;500083 |
Pathway | Toll receptor signaling pathway;PANTHER;P00054 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | FOXM1 transcription factor network;PID Curated;200120 |
Pathway | VEGF signaling pathway;KEGG PATHWAY;hsa04370 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | Endothelin signaling pathway;PANTHER;P00019 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | Neurotrophic factor-mediated Trk receptor signaling;PID Curated;200128 |
Pathway | role of erk5 in neuronal survival pathway;PID BioCarta;100171 |
Pathway | Signaling events mediated by focal adhesion kinase;PID Curated;200192 |
Pathway | Dorso-ventral axis formation;KEGG PATHWAY;hsa04320 |
Pathway | map kinase inactivation of smrt corepressor;PID BioCarta;100032 |
Pathway | roles of beta arrestin dependent recruitment of src kinases in gpcr signaling;PID BioCarta;100230 |
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | calcium signaling by hbx of hepatitis b virus;PID BioCarta;100150 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | links between pyk2 and map kinases;PID BioCarta;100057 |
Pathway | Cellular roles of Anthrax toxin;PID Curated;200179 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | Signal transduction by L1;PID Reactome;500100 |
Pathway | t cell receptor signaling pathway;PID BioCarta;100022 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | mTOR signaling pathway;PID Curated;200080 |
Pathway | fc epsilon receptor i signaling in mast cells;PID BioCarta;100165 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | MAP kinase cascade;BioCyc;PWY66-14 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | ERK1 activation;PID Reactome;500085 |
Pathway | cadmium induces dna synthesis and proliferation in macrophages;PID BioCarta;100209 |
Pathway | Netrin-mediated signaling;PID Curated;200074 |
Pathway | Acute myeloid leukemia;KEGG PATHWAY;hsa05221 |
Disease | Cardiofaciocutaneous syndrome;OMIM |
External Links | |
Links to Entrez Gene | 5604 |
Links to all GeneRIF Items | 5604 |
Links to iHOP | 5604 |
Sequence Information | |
Nucleotide Sequence | >5604 : length: 2603 AGGCGAGGCTTCCCCTTCCCCGCCCCTCCCCCGGCCTCCAGTCCCTCCCAGGGCCGCTTC GCAGAGCGGCTAGGAGCACGGCGGCGGCGGCACTTTCCCCGGCAGGAGCTGGAGCTGGGC TCTGGTGCGCGCGCGGCTGTGCCGCCCGAGCCGGAGGGACTGGTTGGTTGAGAGAGAGAG AGGAAGGGAATCCCGGGCTGCCGAACCGCACGTTCAGCCCGCTCCGCTCCTGCAGGGCAG CCTTTCGGCTCTCTGCGCGCGAAGCCGAGTCCCGGGCGGGTGGGGCGGGGGTCCACTGAG ACCGCTACCGGCCCCTCGGCGCTGACGGGACCGCGCGGGGCGCACCCGCTGAAGGCAGCC CCGGGGCCCGCGGCCCGGACTTGGTCCTGCGCAGCGGGCGCGGGGCAGCGCAGCGGGAGG AAGCGAGAGGTGCTGCCCTCCCCCCGGAGTTGGAAGCGCGTTACCCGGGTCCAAAATGCC CAAGAAGAAGCCGACGCCCATCCAGCTGAACCCGGCCCCCGACGGCTCTGCAGTTAACGG GACCAGCTCTGCGGAGACCAACTTGGAGGCCTTGCAGAAGAAGCTGGAGGAGCTAGAGCT TGATGAGCAGCAGCGAAAGCGCCTTGAGGCCTTTCTTACCCAGAAGCAGAAGGTGGGAGA ACTGAAGGATGACGACTTTGAGAAGATCAGTGAGCTGGGGGCTGGCAATGGCGGTGTGGT GTTCAAGGTCTCCCACAAGCCTTCTGGCCTGGTCATGGCCAGAAAGCTAATTCATCTGGA GATCAAACCCGCAATCCGGAACCAGATCATAAGGGAGCTGCAGGTTCTGCATGAGTGCAA CTCTCCGTACATCGTGGGCTTCTATGGTGCGTTCTACAGCGATGGCGAGATCAGTATCTG CATGGAGCACATGGATGGAGGTTCTCTGGATCAAGTCCTGAAGAAAGCTGGAAGAATTCC TGAACAAATTTTAGGAAAAGTTAGCATTGCTGTAATAAAAGGCCTGACATATCTGAGGGA GAAGCACAAGATCATGCACAGAGATGTCAAGCCCTCCAACATCCTAGTCAACTCCCGTGG GGAGATCAAGCTCTGTGACTTTGGGGTCAGCGGGCAGCTCATCGACTCCATGGCCAACTC CTTCGTGGGCACAAGGTCCTACATGTCGCCAGAAAGACTCCAGGGGACTCATTACTCTGT GCAGTCAGACATCTGGAGCATGGGACTGTCTCTGGTAGAGATGGCGGTTGGGAGGTATCC CATCCCTCCTCCAGATGCCAAGGAGCTGGAGCTGATGTTTGGGTGCCAGGTGGAAGGAGA TGCGGCTGAGACCCCACCCAGGCCAAGGACCCCCGGGAGGCCCCTTAGCTCATACGGAAT GGACAGCCGACCTCCCATGGCAATTTTTGAGTTGTTGGATTACATAGTCAACGAGCCTCC TCCAAAACTGCCCAGTGGAGTGTTCAGTCTGGAATTTCAAGATTTTGTGAATAAATGCTT AATAAAAAACCCCGCAGAGAGAGCAGATTTGAAGCAACTCATGGTTCATGCTTTTATCAA GAGATCTGATGCTGAGGAAGTGGATTTTGCAGGTTGGCTCTGCTCCACCATCGGCCTTAA CCAGCCCAGCACACCAACCCATGCTGCTGGCGTCTAAGTGTTTGGGAAGCAACAAAGAGC GAGTCCCCTGCCCGGTGGTTTGCCATGTCGCTTTTGGGCCTCCTTCCCATGCCTGTCTCT GTTCAGATGTGCATTTCACCTGTGACAAAGGATGAAGAACACAGCATGTGCCAAGATTCT ACTCTTGTCATTTTTAATATTACTGTCTTTATTCTTATTACTATTATTGTTCCCCTAAGT GGATTGGCTTTGTGCTTGGGGCTATTTGTGTGTATGCTGATGATCAAAACCTGTGCCAGG CTGAATTACAGTGAAATTTTGGTGAATGTGGGTAGTCATTCTTACAATTGCACTGCTGTT CCTGCTCCATGACTGGCTGTCTGCCTGTATTTTCGGGATTCTTTGACATTTGGTGGTACT TTATTCTTGCTGGGCATACTTTCTCTCTAGGAGGGAGCCTTGTGAGATCCTTCACAGGCA GTGCATGTGAAGCATGCTTTGCTGCTATGAAAATGAGCATCAGAGAGTGTACATCATGTT ATTTTATTATTATTATTTGCTTTTCATGTAGAACTCAGCAGTTGACATCCAAATCTAGCC AGAGCCCTTCACTGCCATGATAGCTGGGGCTTCACCAGTCTGTCTACTGTGGTGATCTGT AGACTTCTGGTTGTATTTCTATATTTATTTTCAGTATACTGTGTGGGATACTTAGTGGTA TGTCTCTTTAAGTTTTGATTAATGTTTCTTAAATGGAATTATTTTGAATGTCACAAATTG ATCAAGATATTAAAATGTCGGATTTATCTTTCCCCATATCCAAGTACCAATGCTGTTGTA AACAACGTGTATAGTGCCTAAAATTGTATGAAAATCCTTTTAACCATTTTAACCTAGATG TTTAACAAATCTAATCTCTTATTCTAATAAATATACTATGAAATAAAAAAAAAAGGATGA AAGCTAAAAAAAAAAAAAAAAAA |
Protein Sequence | >5604 : length: 393 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV |