| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5599 |
Name | MAPK8 |
Synonymous | mitogen-activated protein kinase 8;MAPK8;mitogen-activated protein kinase 8 |
Definition | JUN N-terminal kinase|MAP kinase 8|c-Jun N-terminal kinase 1|mitogen-activated protein kinase 8 isoform JNK1 alpha1|mitogen-activated protein kinase 8 isoform JNK1 beta2|stress-activated protein kinase 1|stress-activated protein kinase 1c |
Position | 10q11.22 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | JNK1(h) + ATP --MKK7(h){p}--> JNK1(h){p} + ADP (phosphorylation) | JNK1(h) + ATP --MKK4(m){p}--> JNK1(h){p} + ADP (phosphorylation) | MKK7(h) + JNK1(h) <==> MKK7(h):JNK1(h) (binding) | MEKK2(h) + MKK7(h) + JNK1(h) <==> MEKK2(h):MKK7(h):JNK1(h) (binding) | JNK1(h) + ATP --MKK4(h){p}--> JNK1(h){p} + ADP (phosphorylation) | JNK1(h) + DP-1(h) <==> JNK1(h):DP-1(h) (binding) | Evi-1(h) + JNK1(h) <==> Evi-1(h):JNK1(h) (binding) | JNK1(h) + NF-AT4(m) <==> JNK1(h):NF-AT4(m) (binding) | JNK1(h) + JIP1(m) <==> JNK1(h):JIP1(m) (binding) | NFAT2A-alpha(h) + JNK1(h) <==> NFAT2A-alpha(h):JNK1(h) (binding) | JNK1(h) + ATP --MKK7(m)--> JNK1(h){p} + ADP (phosphorylation) | JNK1(h) + JLP(m) <==> JNK1(h):JLP(m) (binding) | MKK4(m) + JLP(m) + JNK1(h) <==> MKK4(m):JLP(m):JNK1(h) (binding) | JNK1(h) + JIP1(h) <==> JNK1(h):JIP1(h) (binding) | JNK1(h) + MKP-1(h) <==> JNK1(h):MKP-1(h) (binding) | JNK1(h) + ATP --MKK4(h){pS221}{pT225}--> JNK1(h){p} + ADP (phosphorylation) | JNK1(h) + WOX1(m){pY33} <==> JNK1(h):WOX1(m){pY33} (binding) | JNK1(h) + WOX1(h) <==> JNK1(h):WOX1(h) (binding) | gamma-synuclein(h) + JNK1(h) <==> gamma-synuclein(h):JNK1(h) (binding) | JNK1(h) + NACP(h) <==> JNK1(h):NACP(h) (binding) | JNK1(h) + ATP --> JNK1(h){p} + ADP (phosphorylation) | c-Myc(h) + JNK1(h) <==> c-Myc(h):JNK1(h) (binding) | JNK1(h) --> JNK1(h) (translocation) [re. | JNK1(h) + 2 ATP --> JNK1(h){pT183}{pY185} + 2 ADP (phosphorylation) | JNK1(h) + ATP --> JNK1(h){pY} + ADP (phosphorylation) | MD-2(h) + JNK1(h) <==> MD-2(h):JNK1(h) (binding) | TLR4(m) + JSAP1(m) + JNK1(h) <==> TLR4(m):JSAP1(m):JNK1(h) (binding) | JNK1(h) + 2 ATP --> JNK1(h){pT}{pY} + 2 ADP (phosphorylation) | MAPK8(h) --> JNK1(h) (expression). | NFAT2A-alpha(h):JNK1(h) + ATP --> NFAT2A-alpha(h){pS117}{pS172} + JNK1(h) + ADP (phosphorylation; dissociation) | JNK1(h) --> JNK1(h) (translocation) [re. | c-Jun(h) + ATP --JNK1(h)--> c-Jun(h){p} + ADP (phosphorylation) | HSF1(h) + ATP --JNK1(h)--> HSF1(h){pS307} + ADP (phosphorylation) | NF-AT1(h) + ATP --JNK1(h)--> NF-AT1(h){p} + ADP (phosphorylation) | c-Jun(m) + ATP --JNK1(h)--> c-Jun(m){p} + ADP (phosphorylation) | BimL(h) + ATP --JNK1(h)--> BimL(h){p} + ADP (phosphorylation) | Bmf(h) + ATP --JNK1(h)--> Bmf(h){p} + ADP (phosphorylation) | HIPK1(h) + ATP --JNK1(h)--> HIPK1(h){p} + ADP (phosphorylation) | c-Jun(h) + 2 ATP --JNK1(h)--> c-Jun(h){pS63}{pS73} + 2 ADP (phosphorylation) | RXR-alpha(m) + ATP --JNK1(h)--> RXR-alpha(m){pS265} + ADP (phosphorylation) | NR1B1(m) + ATP --JNK1(h)--> NR1B1(m){p} + ADP (phosphorylation) | BOD-L(r) + ATP --JNK1(h)--> BOD-L(r){p} + ADP (phosphorylation) | c-Myc(h) + ATP --JNK1(h)--> c-Myc(h){p} + ADP (phosphorylation) | c-Jun(m.s.) + ATP --JNK1(h)--> c-Jun(m.s.){p} + ADP (phosphorylation) | c-Jun(h) + ATP --JNK1(h)--> c-Jun(h){p} + ADP (phosphorylation) | c-Jun(m.s.) + 2 ATP --JNK1(h)--> c-Jun(m.s.){pS63}{pS73} + 2 ADP (phosphorylation) | MKK7-isoform1(h) + JNK1alpha1(h) <==> MKK7-isoform1(h):JNK1alpha1(h) (binding) | MAPK8(h) --> JNK1alpha1(h) (expression). | c-Ets-1(m) + ATP --JNK1alpha1(h)--> c-Ets-1(m){p} + ADP (phosphorylation) | c-Jun(v.s.) + ATP --JNK1alpha1(h)--> c-Jun(v.s.){p} + ADP (phosphorylation) | MAP-2(m) + ATP --JNK1alpha1(h)--> MAP-2(m){p} + ADP (phosphorylation) | MAP-2(b) + ATP --JNK1alpha1(h)--> MAP-2(b){p} + ADP (phosphorylation) | TAB1(h) + 2 ATP --JNK1alpha1(h)--> TAB1(h){pT431}{pS438} + 2 ADP (phosphorylation) | c-Jun(h) + ATP --JNK1alpha1(h)--> c-Jun(h){p} + ADP (phosphorylation) | ATF-2(h) + ATP --JNK1alpha1(h)--> ATF-2(h){p} + ADP (phosphorylation) | APP(m):JIP1-isoform1(m) + JNK1beta1(h) <==> APP(m):JIP1-isoform1(m):JNK1beta1(h) (binding) | JNK1beta1(h) + ATP --> JNK1beta1(h){p} + ADP (phosphorylation) | MAPK8(h) --> JNK1beta1(h) (expression). | MAPK8(h) --> JNK1alpha2(h) (expression). | MAPK8(h) --> JNK1beta2(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 183 | Phosphothreonine. | Swiss-Prot 53.0 | 185 | Phosphotyrosine. | Swiss-Prot 53.0 | 377 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 183 | Phosphothreonine (MAP2K7) | 95141073;15911620;15755722;9312068 | Phospho.ELM 6.0 | 185 | Phosphotyrosine (MAP2K4;MAP2K) | 95141073;15911620;15755722;9312068 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for MAPK8 | ||