Cell senescence gene database Home
Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

5599

Name

MAPK8

Synonymous

mitogen-activated protein kinase 8;MAPK8;mitogen-activated protein kinase 8

Definition

JUN N-terminal kinase|MAP kinase 8|c-Jun N-terminal kinase 1|mitogen-activated protein kinase 8 isoform JNK1 alpha1|mitogen-activated protein kinase 8 isoform JNK1 beta2|stress-activated protein kinase 1|stress-activated protein kinase 1c

Position

10q11.22

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.565C>G; p.R189G; 10:48420269-48420269

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.649G>T; p.E217*; 10:48424120-48424120

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1138+2T>C; p.?; 10:48431272-48431272

 skin; anklemalignant_melanoma; acral_lentiginousUnknown

c.1138+2T>C; p.?; 10:48431272-48431272

 skinmalignant_melanomaUnknown

c.290C>T; p.S97F; 10:48409916-48409916

 skinmalignant_melanomaSubstitution - Missense

c.290C>T; p.S97F; 10:48409916-48409916

 skinmalignant_melanomaSubstitution - Missense

c.303T>G; p.F101L; 10:48409929-48409929

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.123C>T; p.C41C; 10:48404852-48404852

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1021C>T; p.Q341*; 10:48427104-48427104

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.302T>C; p.F101S; 10:48409928-48409928

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.302T>C; p.F101S; 10:48409928-48409928

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.359A>G; p.Q120R; 10:48410077-48410077

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.217G>T; p.E73*; 10:48404946-48404946

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.529G>A; p.G177R; 10:48420233-48420233

 central_nervous_system; braingliomaSubstitution - Missense

c.529G>A; p.G177R; 10:48420233-48420233

 central_nervous_system; braingliomaSubstitution - Missense

c.431C>T; p.S144F; 10:48410149-48410149

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.530G>T; p.G177V; 10:48420234-48420234

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.719A>G; p.Q240R; 10:48425918-48425918

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1061-1G>T; p.?; 10:48431192-48431192

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.549G>A; p.T183T; 10:48420253-48420253

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.548C>T; p.T183M; 10:48420252-48420252

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.566G>A; p.R189H; 10:48420270-48420270

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.548C>T; p.T183M; 10:48420252-48420252

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.247A>T; p.K83*; 10:48404976-48404976

 livercarcinoma; hepatocellular_carcinomaSubstitution - Nonsense

c.17G>A; p.R6H; 10:48401677-48401677

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.30T>C; p.F10F; 10:48401690-48401690

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.374A>G; p.H125R; 10:48410092-48410092

 central_nervous_system; braingliomaSubstitution - Missense

c.343C>A; p.L115I; 10:48410061-48410061

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.343C>A; p.L115I; 10:48410061-48410061

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.360G>T; p.Q120H; 10:48410078-48410078

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.531A>G; p.G177G; 10:48420235-48420235

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.739G>T; p.E247*; 10:48425938-48425938

 stomachcarcinomaSubstitution - Nonsense

c.510C>T; p.F170F; 10:48420214-48420214

 skinmalignant_melanomaSubstitution - coding silent

c.739G>C; p.E247Q; 10:48425938-48425938

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.92C>T; p.P31L; 10:48401752-48401752

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.205C>T; p.R69W; 10:48404934-48404934

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.192delG; p.T65fs*10; 10:48404921-48404921

 boneosteosarcomaDeletion - Frameshift

c.513T>C; p.G171G; 10:48420217-48420217

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.231G>T; p.M77I; 10:48404960-48404960

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.513T>C; p.G171G; 10:48420217-48420217

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.358C>T; p.Q120*; 10:48410076-48410076

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.307G>T; p.D103Y; 10:48409933-48409933

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.826C>T; p.P276S; 10:48426025-48426025

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.343C>T; p.L115F; 10:48410061-48410061

 skin; facecarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.511G>A; p.G171S; 10:48420215-48420215

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.511G>A; p.G171S; 10:48420215-48420215

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.16C>T; p.R6C; 10:48401676-48401676

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.74G>A; p.R25Q; 10:48401734-48401734

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.74G>A; p.R25Q; 10:48401734-48401734

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.72A>G; p.K24K; 10:48401732-48401732

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.261_262CC>TT; p.L88F; 10:48409887-48409888

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.547A>G; p.T183A; 10:48420251-48420251

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.778G>A; p.V260I; 10:48425977-48425977

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.959A>G; p.Y320C; 10:48426467-48426467

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.847G>C; p.D283H; 10:48426046-48426046

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.670C>T; p.L224F; 10:48424141-48424141

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.592C>T; p.L198F; 10:48420296-48420296

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.830A>T; p.D277V; 10:48426029-48426029

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.737C>G; p.P246R; 10:48425936-48425936

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.582C>A; p.P194P; 10:48420286-48420286

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.691A>G; p.I231V; 10:48425890-48425890

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.582C>A; p.P194P; 10:48420286-48420286

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.594T>C; p.L198L; 10:48420298-48420298

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.445C>T; p.H149Y; 10:48410163-48410163

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.565C>T; p.R189C; 10:48420269-48420269

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.360G>A; p.Q120Q; 10:48410078-48410078

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.363G>A; p.M121I; 10:48410081-48410081

 skinmalignant_melanomaSubstitution - Missense

c.112G>A; p.G38R; 10:48401772-48401772

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1015G>A; p.D339N; 10:48427098-48427098

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.997-1G>A; p.?; 10:48427079-48427079

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.112G>C; p.G38R; 10:48401772-48401772

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.566G>T; p.R189L; 10:48420270-48420270

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.124G>A; p.A42T; 10:48404853-48404853

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.124G>A; p.A42T; 10:48404853-48404853

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.73C>T; p.R25*; 10:48401733-48401733

 breastcarcinomaSubstitution - Nonsense

c.906G>T; p.L302L; 10:48426414-48426414

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.138C>T; p.A46A; 10:48404867-48404867

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.448C>T; p.R150W; 10:48410166-48410166

 breastcarcinomaSubstitution - Missense

c.649G>C; p.E217Q; 10:48424120-48424120

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.739G>A; p.E247K; 10:48425938-48425938

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.1060+2T>C; p.?; 10:48427145-48427145

 stomachcarcinoma; adenocarcinomaUnknown

c.207G>T; p.R69R; 10:48404936-48404936

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.796T>A; p.Y266N; 10:48425995-48425995

 skinmalignant_melanomaSubstitution - Missense

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