| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5599 |
Name | MAPK8 |
Synonym | JNK|JNK-46|JNK1|JNK1A2|JNK21B1/2|PRKM8|SAPK1|SAPK1c;mitogen-activated protein kinase 8;MAPK8;mitogen-activated protein kinase 8 |
Definition | JUN N-terminal kinase|MAP kinase 8|c-Jun N-terminal kinase 1|mitogen-activated protein kinase 8 isoform JNK1 alpha1|mitogen-activated protein kinase 8 isoform JNK1 beta2|stress-activated protein kinase 1|stress-activated protein kinase 1c |
Position | 10q11.22 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | RIG-I-like receptor signaling pathway;KEGG PATHWAY;hsa04622 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | TGF-beta signaling pathway;PANTHER;P00052 |
Pathway | pdgf signaling pathway;PID BioCarta;100077 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | N-cadherin signaling events;PID Curated;200180 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | egf signaling pathway;PID BioCarta;100181 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | atm signaling pathway;PID BioCarta;100235 |
Pathway | inhibition of cellular proliferation by gleevec;PID BioCarta;100154 |
Pathway | fas signaling pathway (cd95);PID BioCarta;100167 |
Pathway | Endothelins;PID Curated;200004 |
Pathway | Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | toll-like receptor pathway;PID BioCarta;100013 |
Pathway | bcr signaling pathway;PID BioCarta;100227 |
Pathway | IL1-mediated signaling events;PID Curated;200075 |
Pathway | nfat and hypertrophy of the heart ;PID BioCarta;100098 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | Glypican 3 network;PID Curated;200193 |
Pathway | Activation of BMF and translocation to mitochondria;PID Reactome;500263 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | Syndecan-2-mediated signaling events;PID Curated;200164 |
Pathway | Nephrin/Neph1 signaling in the kidney podocyte;PID Curated;200132 |
Pathway | TRAIL signaling pathway;PID Curated;200056 |
Pathway | Interferon-gamma signaling pathway;PANTHER;P00035 |
Pathway | IL12 signaling mediated by STAT4;PID Curated;200197 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | hypoxia and p53 in the cardiovascular system;PID BioCarta;100084 |
Pathway | Oxidative stress response;PANTHER;P00046 |
Pathway | Shigellosis;KEGG PATHWAY;hsa05131 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | CD40/CD40L signaling;PID Curated;200031 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | NRIF signals cell death from the nucleus;PID Reactome;500610 |
Pathway | JNK signaling in the CD4+ TCR pathway;PID Curated;200129 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | Downstream signaling in naive CD8+ T cells;PID Curated;200184 |
Pathway | Epithelial cell signaling in Helicobacter pylori infection;KEGG PATHWAY;hsa05120 |
Pathway | Noncanonical Wnt signaling pathway;PID Curated;200016 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Alzheimer disease-amyloid secretase pathway;PANTHER;P00003 |
Pathway | regulation of map kinase pathways through dual specificity phosphatases;PID BioCarta;100185 |
Pathway | Activation of BH3-only proteins;PID Reactome;500260 |
Pathway | ceramide signaling pathway;PID BioCarta;100206 |
Pathway | agrin in postsynaptic differentiation;PID BioCarta;100252 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | Ephrin B reverse signaling;PID Curated;200173 |
Pathway | RhoA signaling pathway;PID Curated;200007 |
Pathway | ATF-2 transcription factor network;PID Curated;200116 |
Pathway | p75(NTR)-mediated signaling;PID Curated;200103 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | Cell death signalling via NRAGE, NRIF and NADE;PID Reactome;500608 |
Pathway | NOD-like receptor signaling pathway;KEGG PATHWAY;hsa04621 |
Pathway | hiv-1 nef: negative effector of fas and tnf;PID BioCarta;100144 |
Pathway | Ras Pathway;PANTHER;P04393 |
Pathway | FAS signaling pathway;PANTHER;P00020 |
Pathway | CDC42 signaling events;PID Curated;200057 |
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | bioactive peptide induced signaling pathway;PID BioCarta;100226 |
Pathway | Regulation of Androgen receptor activity;PID Curated;200102 |
Pathway | keratinocyte differentiation;PID BioCarta;100119 |
Pathway | S1P2 pathway;PID Curated;200181 |
Pathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling;PID BioCarta;100236 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | bone remodeling;PID BioCarta;100052 |
Pathway | Activation of BIM and translocation to mitochondria;PID Reactome;500262 |
Pathway | nerve growth factor pathway (ngf);PID BioCarta;100096 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | role of mal in rho-mediated activation of srf;PID BioCarta;100114 |
Pathway | FAS (CD95) signaling pathway;PID Curated;200067 |
Pathway | Ceramide signaling pathway;PID Curated;200100 |
Pathway | tnf/stress related signaling;PID BioCarta;100026 |
Pathway | RAC1 signaling pathway;PID Curated;200190 |
Pathway | Signaling events regulated by Ret tyrosine kinase;PID Curated;200058 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Glucocorticoid receptor regulatory network;PID Curated;200077 |
Pathway | igf-1 signaling pathway;PID BioCarta;100136 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | Retinoic acid receptors-mediated signaling;PID Curated;200142 |
Pathway | Toll receptor signaling pathway;PANTHER;P00054 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | NRAGE signals death through JNK;PID Reactome;500609 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | EPO signaling pathway;PID Curated;200157 |
Pathway | Osteopontin-mediated events;PID Curated;200042 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | Reelin signaling pathway;PID Curated;200051 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | Signaling events mediated by focal adhesion kinase;PID Curated;200192 |
Pathway | Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920 |
Pathway | ErbB2/ErbB3 signaling events;PID Curated;200119 |
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | Parkinson disease;PANTHER;P00049 |
Pathway | signal transduction through il1r;PID BioCarta;100132 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | Rapid glucocorticoid signaling;PID Curated;200090 |
Pathway | links between pyk2 and map kinases;PID BioCarta;100057 |
Pathway | il12 and stat4 dependent signaling pathway in th1 development;PID BioCarta;100133 |
Pathway | t cell receptor signaling pathway;PID BioCarta;100022 |
Pathway | Protein processing in endoplasmic reticulum;KEGG PATHWAY;hsa04141 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | fc epsilon receptor i signaling in mast cells;PID BioCarta;100165 |
Pathway | Angiopoietin receptor Tie2-mediated signaling;PID Curated;200066 |
Pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes;PID Curated;200076 |
Pathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha;PID Curated;200133 |
Pathway | integrin signaling pathway;PID BioCarta;100123 |
Pathway | FoxO family signaling;PID Curated;200091 |
Pathway | Type II diabetes mellitus;KEGG PATHWAY;hsa04930 |
External Links | |
Links to Entrez Gene | 5599 |
Links to all GeneRIF Items | 5599 |
Links to iHOP | 5599 |
Sequence Information | |
Nucleotide Sequence | >5599 : length: 6069 GTTACTCAGCCGAGCGGCCGAGGCCGGACGACGCGGCTTGGATTGCGGAGCCGCGAGCAG CGCTGGGTAACGGCCGCGGCGACCACCCCGGACGGCCCCTGTCCCCGCTGGCGGGCTTCC CTGTCGCCGTTCGCTGCGCTGCCGGTCTTGCAGCCTTACAGTCATTTGTAATGGTTACCT CAGATTCCCCTGCTGTGGTTAACGTTAAACCTAGGAGGTCAGATGCTCTAAGTGAACATG TTTAGTGCTGTGCCTGACAAAAGCAAGCAATCAAAATGGGACTTCCTTGAGGGCAGGCCT GTCTTGCATCTGTTTCTCCACCACCTAGCCTGGAATATAACTGGCCTTATGGGTTTCTAG AAGGAAAATCACAGAGGTAAAGCATCATTTCATCACATCCTGTCAAGGCTTCTTGGTGAA TTTTTGGATGAAGCCATTAAATTAATTGCTTGCCATCATGAGCAGAAGCAAGCGTGACAA CAATTTTTATAGTGTAGAGATTGGAGATTCTACATTCACAGTCCTGAAACGATATCAGAA TTTAAAACCTATAGGCTCAGGAGCTCAAGGAATAGTATGCGCAGCTTATGATGCCATTCT TGAAAGAAATGTTGCAATCAAGAAGCTAAGCCGACCATTTCAGAATCAGACTCATGCCAA GCGGGCCTACAGAGAGCTAGTTCTTATGAAATGTGTTAATCACAAAAATATAATTGGCCT TTTGAATGTTTTCACACCACAGAAATCCCTAGAAGAATTTCAAGATGTTTACATAGTCAT GGAGCTCATGGATGCAAATCTTTGCCAAGTGATTCAGATGGAGCTAGATCATGAAAGAAT GTCCTACCTTCTCTATCAGATGCTGTGTGGAATCAAGCACCTTCATTCTGCTGGAATTAT TCATCGGGACTTAAAGCCCAGTAATATAGTAGTAAAATCTGATTGCACTTTGAAGATTCT TGACTTCGGTCTGGCCAGGACTGCAGGAACGAGTTTTATGATGACGCCTTATGTAGTGAC TCGCTACTACAGAGCACCCGAGGTCATCCTTGGCATGGGCTACAAGGAAAACGTGGATTT ATGGTCTGTGGGGTGCATTATGGGAGAAATGGTTTGCCACAAAATCCTCTTTCCAGGAAG GGACTATATTGATCAGTGGAATAAAGTTATTGAACAGCTTGGAACACCATGTCCTGAATT CATGAAGAAACTGCAACCAACAGTAAGGACTTACGTTGAAAACAGACCTAAATATGCTGG ATATAGCTTTGAGAAACTCTTCCCTGATGTCCTTTTCCCAGCTGACTCAGAACACAACAA ACTTAAAGCCAGTCAGGCAAGGGATTTGTTATCCAAAATGCTGGTAATAGATGCATCTAA AAGGATCTCTGTAGATGAAGCTCTCCAACACCCGTACATCAATGTCTGGTATGATCCTTC TGAAGCAGAAGCTCCACCACCAAAGATCCCTGACAAGCAGTTAGATGAAAGGGAACACAC AATAGAAGAGTGGAAAGAATTGATATATAAGGAAGTTATGGACTTGGAGGAGAGAACCAA GAATGGAGTTATACGGGGGCAGCCCTCTCCTTTAGCACAGGTGCAGCAGTGATCAATGGC TCTCAGCATCCATCATCATCGTCGTCTGTCAATGATGTGTCTTCAATGTCAACAGATCCG ACTTTGGCCTCTGATACAGACAGCAGTCTAGAAGCAGCAGCTGGGCCTCTGGGCTGCTGT AGATGACTACTTGGGCCATCGGGGGGTGGGAGGGATGGGGAGTCGGTTAGTCATTGATAG AACTACTTTGAAAACAATTCAGTGGTCTTATTTTTGGGTGATTTTTCAAAAAATGTAGAA TTCATTTTGTAGTAAAGTAGTTTATTTTTTTTAATTTCAAGTGATGTAATTTAAAACCTA AGTTGTGTTTCAAAACAGCAACAAAACTGTATTGTATTTTTTTTGCTGTAATTAACTGTA TAATGTAAACCTAATTATTTTATCATGGTTTAAATTTTTTGCATATTTGCTTTATCTTAT GCTGCTGATTTTTTTAACTGAATTTGTAAGATTTTGTTTATCAAAGCAACTATTATGTGG TGACTTGCCTATATCATGAATTATTTAAGATTTTTATAGTTTTTTTTAATTAGAATTTAT TTCAGATGTTTTGTTCATGATACTATCCTTCAGGGTTATGTGCTTATCAATGAAATAACC CCAGAGGAGTGAGGGAAAATAACTTGTAGCCAGTTATATTCAGGAATAACTACTGTAAAT GATGAACGTGTTAGGAGACCTCCAATATTTGCTACTTGCCAATCCTAATTTAGTTACAAG AATTGGTAGGCAATCCTACTTAATTTTGGCAAAAGCCCCGTCATCTAAATGGCAGAATAA CTCAGAGCATGTCTTTGAAGATGCTGGGCGTCTACCACCACCTTATGTCCCCACCCTACC CAACAAAAATAAGTAAAAAGAATATGGTGTATTCTACAAATTTGTGGCATGCTCAAAGTT TATGATCACATAAAGGCAAGAGGATACTTCATGAATAATACATTTCAATGCAAATAAACA GATGGTTCACTTCTACTAGCTATGAGCCTGTTTTTGTATACACTGAGTTAATCTACTCAG GCTGTAGGTCCCAGCAATGTTCTAGAGTCTGGTCTTTCCCTTTCCTGCAGCTTCGGGTCC TTGGACCTTTCCTGTTTCCTATTACTTGGAGTGTCTGTCAGTTGAGCACCAGTTGTTCTG GTGTTTCATTTGATTCTACTTGTAGCATAATCATTTATACGAGCTATTGGGAGGTTCCAA ACCCTACCTAGATTTGTGTAGGTGATGTATCAAATGAGCAATATACCGTTCATCTGAAAA TAGTAGCACACAGCCATATATAGGATATCATTTTCTAAGGACTGTTTCTTCACATTGAGC AGAGCAGGCATAAATGGTGGTTATTTAGTCTAAGTCTTTTATTTTTTTATACCTGATTTT CAACATAACACGCAATGTGGATGTCGAGTAGTGTTAAGAATGGTGCTGCTCCTGACAAGT GTATGTTAACTGTTTACATTTTCTATCTGTAGAATTATTTCTCTATTACTGAACTTTTCC TAAGTAAAATGTCTTTGAAGTCTCGTTATTTCTGAAATACGTTGTCTGTAATAGACCCAG GCACCTTTTAAATTATCTCTGGAACAAGAGGGATTTCATGTAATGAACTAGGAAATGCAT ACTCACATAAGCAACAAGGTTCTAGGCAGAAAGCCCCTTGGAATTTGTGACCAACAGGAG CAAGAACAGGTGCGGCTCAACATGCAATGTCTGAAAATTTGCTTGGCATTTTATTCATAT ATTTAGTGCAAAATTATTTTTGAGTGAGATATTTTACATCACTGTTAATGTGCAATATTT AAGATTAAAATACATTAGCTTTTTTATATACTTTGAAGTAGCAAGTTTGTTTTCGATGGC TTAGAGTCATGATTTCCAGCTTCCCAGCCTTTTTATCAGTCCCTTTTCTAATACAACAAG GTGCATTAATTTGATTAGGCAAATTAGAGTTCTAAGACACTTCTTGAATTGTAGACAGAA AATATTGGATTCACAATTTCAGCAGAAATTTGAGAATGAGTGTGTTTATATTAATTTCAC AATTAGCTGTATTTTCTGTAGCATAGATTATGTCACTGTTGCACTTTCACAGCAGACATG CTTTCAGAAGGTTCTCATATTTTATGTTTGATTGCTGATAAGCCATCTCTATTGATACAG ATTTTGGTTAAGTAAGGAAAACCAGGTGTGTGTCTGTATCATTTATTGTAAATGCCAGCT GCCACTTGCCAACCATCATGTTCAGTTCAATTCAAAGAAAACAAACTCTCATTACTTAGT GTAAACTAAAATACTTAACAAATTATATCCTAAAAACAAGGTCTCTTTGTTAAATGTTGC ATGCCCTAGGTTTTAAATTACTACATCCAAATACAGTTTTCGTCTTAAATTTGTTAAGCT AAATATATGTTGGTTCTTTTTATTTTGGAATCCTTTAAGCATCTTAAACATTTTTTTTTT GAAGAGAAGTTACAAATAACATTTCTATCAGGTAGTACTTGTATGAAACCACCTTTCTTA TTCTATAATTTTGATTTTTCAATTTTATATACTTAATATACTCACTGTCTTACTATCAGA AAGTTATTTTGACCAAGATTTTTATTATCTTCATAGATTCAGAAAGAGATGCTAATTCTG TACCAATGTCTTCCTGGTTACTATTCTCTTCCCTCTAATATATACTGGCCATTTGTAAAA CCATTGTGTTGTTGGGATCACTTAGTTATACTATACGCAGATAGAGCATCTCAACTCTGT CATAGTGTTTGCTGAACAGTTTTCAGTGTCATGCACCTTTGGCTGCTAATTGTTCCTGAC GTGCACTCTTCCGAGTTGGTAAAGGCACAGTGTGTTCATGCCAGACTTCTAAGAGAAACA CCAGCCTCTTAAATCAGAAGCCTACACACAACCCCCTTAACAATCCAAAGAAGCTTGATG GTGTGCAAAGAAGCATCCTGCCAGCCTTGTCATTGTTCTGTTCTATGCTAATCCTGCTGT GTTGTCTAAAAGATGGAGGGAAGAGGACATCAGTGTCTGATAGTGAAATCATCAGCAGGA AAGTGAAGCTCTTTCCTTGGTTACAGATAAGACTTGGTTTACACTATTGGCCAGTATCTG CTAAACATATGAAGACTTAACTATTCAGTGTTGCCTAGGCATTCGCCTGCACAACATTTT GAGGTTAGAACATAGAATATTTTCAGAAATACTGTTGTAGTTTGTGAGTGTTGTTCATTA GTTACACATTAGCTATAGAGTGGATGCATGAAGCCCCATGACACCAGTAAACTTCTCTTA CCAGTAGGTAAACCAAACACCATTCTGTCATTAGCAGCCCTCTTAAATGTTGCCTCTCCG TATCCTGTTGCATTTTTGTGTGCATTGTGTTTCTACTGATCTCTCTTAGGTTTTTACGGA ATCAAAGGAAACTAATTTTTCCTTAATAGCAAGAAAGATGAAGAGGTAAAGGGCATTGAA GCAGAAATGTATAGTTTGGGGTACGATTAGAAAACTCGTAAGGAAAACAGAAGTCCTAAT TTCAAACTGACTGCTCTTCGTTAAGTGCTCTTAAGGAGAGTCTAGTAACAGTAACACTTT CTGGCCATTTCTAGTTTAGATTCTCTTCGTTACTGAAACTTTTGAGAAATATTACCTGTG GATTAATTTTGCACAATGTTCTATTCTCATAATGACTTACAAATTAAACTAGGTTTTTAT TGAACTACCTCACACTAATTTTCTATGCTTTCCCAAGTAAGCTGTTGCCCTGTTAGATCT TTACTGAGTGAATTATAAATGTGTGTTAAATACTTTCTAGCCAATGTTGACACAATACCA GTAAGTATGTAAAGTATATACCTTACATCAGTAAGAGACACGTGTAAAATCTTTGACTGT ATGTCTTGCAAAATTGTGCTCGTTGACATTATTACTGTTTTTGTAAGTAGAAACCTGCTC GTGATATCGGTCCATTTACATTTTACAAAAGGAGTAAATCTTAGTAAAAATTTTACGAAG AAATAAATTACTTTTGTAGGCCCAATATTTGGTATATTTTTGAGAAGCTGTTAATCTTTT AGCTGAATAATGAAGTTAGACTGAATTACGTGTCTCCCTGGACTGTGACATCTATTTTCT CATTACAGTTTATCCTGGTCAGCAGGGTGTCACACCTGGAAACCTGAGTATGATAGCTGA CATTTGCTTTTCTCCCTCTGCGATGTCATTCCTCCTCCATTCCTCTCCTTCCCTGTGTTC CGTTCCCTCTCCTTTCCTCTAGACAAAACAAAATGGGGCACTTTTTAGGGAATGCTGAGA TCATTATTGTGGTTTTTCATCATTCATGCCCTAGTCATTAAACATGCACCACTGGAATGT AAACAATGTTATCTAGTATGTCAATTGGTTATAATATTTTAAATAAAAAAGAAAAAAGTG GTATGAAAA |
Protein Sequence | >5599 : length: 427 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA GPLGCCR |