| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5595 |
Name | MAPK3 |
Synonymous | mitogen-activated protein kinase 3;MAPK3;mitogen-activated protein kinase 3 |
Definition | MAP kinase isoform p44|MAPK 1|extracellular signal-regulated kinase 1|extracellular signal-related kinase 1|insulin-stimulated MAP2 kinase|microtubule-associated protein 2 kinase |
Position | 16p11.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | ERK1(h) + MP1(m) <==> ERK1(h):MP1(m) (binding) | MEK1(r) + ERK1(h) + MP1(m) <==> MEK1(r):ERK1(h):MP1(m) (binding) | ERK1(h) + ATP --> ERK1(h){p} + ADP (phosphorylation) | ERK1(h) + Mnk1(m) <==> ERK1(h):Mnk1(m) (binding) | ERK1(h) + MNK2(m) <==> ERK1(h):MNK2(m) (binding) | ERK1(h) + ATP --MEK2(h)--> ERK1(h){p} + ADP (phosphorylation) | ERK1(h) + RSK1(h) <==> ERK1(h):RSK1(h) (binding) | ERK1(h) + RSK1(v.s.) <==> ERK1(h):RSK1(v.s.) (binding) | ERK1(h) + RSK2(h) <==> ERK1(h):RSK2(h) (binding) | ERK1(h) + RSK3(h) <==> ERK1(h):RSK3(h) (binding) | gamma-synuclein(h) + ERK1(h) <==> gamma-synuclein(h):ERK1(h) (binding) | ERK1(h) + NACP(h) <==> ERK1(h):NACP(h) (binding) | ERK1(h) + ATP --MEK(h)--> ERK1(h){p} + ADP (phosphorylation) | ERK1(h) + ATP --Lck(m.s.)--> ERK1(h){pY} + ADP (phosphorylation) | ERK1(h) + ATP --MEK1(h)--> ERK1(h){p} + ADP (phosphorylation) | betaARK-1(b) + ERK1(h) <==> betaARK-1(b):ERK1(h) (binding) | PTP-SL(m) + ERK1(h) <==> PTP-SL(m):ERK1(h) (binding) | STEP(r) + ERK1(h) <==> STEP(r):ERK1(h) (binding) | ERK1(h) + ATP --> ERK1(h){pT202} + ADP (phosphorylation) | ERK1(h) + ATP --> ERK1(h){pY} + ADP (phosphorylation) | ERK1(h) + 2 ATP --> ERK1(h){pT202}{pY204} + 2 ADP (phosphorylation) | NURR1(h) + ERK1(h) <==> NURR1(h):ERK1(h) (binding) | ERK1(h) + MSK1(h) <==> ERK1(h):MSK1(h) (binding) | ERK1(h) + 2 ATP --> ERK1(h){pT}{pY} + 2 ADP (phosphorylation) | ERK1(h) --> MIP1A(h):CKR-5(h) (increase of binding) | ERK1(h) + iNOS(h) <==> ERK1(h):iNOS(h) (binding) | ERK1(h) + ATP --> ERK1(h){pY204} + ADP (phosphorylation) | ERK1(h) --/ FOXN1(h) (transrepression) | ERK1(h) + SK1(h) <==> ERK1(h):SK1(h) (binding) | ERK1(h) + sphingosine kinase 2 isoform-2(h) <==> ERK1(h):sphingosine kinase 2 isoform-2(h) (binding) | ERK1(h) --/ NOTCH1(h) (transrepression) | MAPK3(h) --> ERK1(h) (expression). | ERK1(h){p} --DUSP5(h)--> ERK1(h) + p (dephosphorylation) | ERK1(h){p} --VHR(h)--> ERK1(h) + p (dephosphorylation) | ERK1(h){p} --MKP-2(h)--> ERK1(h) + p (dephosphorylation) | ERK1(h){p} --MKP-1(h)--> ERK1(h) + p (dephosphorylation) | DEFA1(h) --> ERK1(h) (activation) | proHNP3(h) --> ERK1(h) (activation) | catalase(m.s.) --> ERK1(h) (regulation of abundance) | Cot(m.s.) --> ERK1(h) (activation) | ERK1(h){pT202}{pY204} --DUSP5(m.s.)--> ERK1(h) + 2 p (dephosphorylation) | HSF1(h) + ATP --ERK1(h)--> HSF1(h){pS307} + ADP (phosphorylation) | betaARK-1(b) + ATP --ERK1(h)--> betaARK-1(b){pS670} + ADP (phosphorylation) | c-Ets-1(m) + ATP --ERK1(h)--> c-Ets-1(m){pT38} + ADP (phosphorylation) | calpain-2(pg) + ATP --ERK1(h)--> calpain-2(pg){pS50} + ADP (phosphorylation) | arachidonate 5-lipoxygenase(h) + ATP --ERK1(h)--> arachidonate 5-lipoxygenase(h){p} + ADP (phosphorylation) | RSK3(h) + ATP --ERK1(h)--> RSK3(h){p} + ADP (phosphorylation) | ZNF-7(h) + ATP --ERK1(h)--> ZNF-7(h){p} + ADP (phosphorylation) | HSF1(h) + ATP --ERK1(h)--> HSF1(h){p} + ADP (phosphorylation) | RalGDS(h) + ATP --ERK1(h)--> RalGDS(h){p} + ADP (phosphorylation) | topoisomerase-II-beta(h) + ATP --ERK1(h)--> topoisomerase-II-beta(h){p} + ADP (phosphorylation) | c-Myc(h) + ATP --ERK1(h)--> c-Myc(h){p} + ADP (phosphorylation) | Elk-1(h) + ATP --ERK1(h)--> Elk-1(h){p} + ADP (phosphorylation) | Mnk1(h) + ATP --ERK1(h)--> Mnk1(h){p} + ADP (phosphorylation) | c-Jun(m.s.) + ATP --ERK1(h)--> c-Jun(m.s.){p} + ADP (phosphorylation) | Elk-1(m.s.) + ATP --ERK1(h)--> Elk-1(m.s.){p} + ADP (phosphorylation) | ATF-2(m.s.) + ATP --ERK1(h)--> ATF-2(m.s.){p} + ADP (phosphorylation) | BOD-L(r) + ATP --ERK1(h)--> BOD-L(r){p} + ADP (phosphorylation) | Bcl-2(h) + ATP --ERK1(h)--> Bcl-2(h){pS70} + ADP (phosphorylation) | betaARK-1(b) + ATP --ERK1(h)--> betaARK-1(b){p} + ADP (phosphorylation) | Elk-1(m.s.) + ATP --ERK1(h)--> Elk-1(m.s.){pS383} + ADP (phosphorylation) | Elk1-isoform1(h) + ATP --ERK1(h)--> Elk1-isoform1(h){pS383} + ADP (phosphorylation) | ERK1(h) + 2 ATP --> ERK1(h){pT202}{pY204} + 2 ADP (phosphorylation) | ERK1(h) + MEK1(h) <==> ERK1(h):MEK1(h) (binding) | ERK1(h) + MEK2(h) <==> ERK1(h):MEK2(h) (binding) | MAPK3(h) --> ERK1(h) (expression). | Smad2-L(h) + 5 ATP --ERK1(h)--> Smad2-L(h){pT8}{pT220}{pS245}{pS250}{pS255} + 5 ADP (phosphorylation) | ERR1(h) + ATP --ERK1(h)--> ERR1(h){p} + ADP (phosphorylation) | 4E-BP1(m.s.) + ATP --ERK1(h)--> 4E-BP1(m.s.){p} + ADP (phosphorylation) |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 2 | N-acetylalanine (By similarity). | Swiss-Prot 53.0 | 202 | Phosphothreonine. | Swiss-Prot 53.0 | 204 | Phosphotyrosine. | Swiss-Prot 53.0 | 203 | Phosphotyrosine (MAP2K1;MAP2K) | 7867743;8626767;16464493;15466476;11971971;1708198 | Phospho.ELM 6.0 | 201 | Phosphothreonine (MAP2K1;MAP2K) | 8626767;93330262;15466476;11971971 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr16 |
Promoter: 30041631 - 30043631 | GSE27584 |
chr16 |
Promoter: 30041631 - 30043631 | GSE27584 |
chr16 |
Promoter: 30041631 - 30043631 | Agilent_014791 |