| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4214 |
Name | MAP3K1 |
Synonymous | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase;MAP3K1;mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase |
Definition | MAP/ERK kinase kinase 1|MAPK/ERK kinase kinase 1|MEK kinase 1|mitogen-activated protein kinase kinase kinase 1 |
Position | 5q11.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | MEKK1(h) --> Trx1(h){reC}2 (activation) | GCK(h) + MEKK1(h) <==> GCK(h):MEKK1(h) (binding) | 2 MEKK1(h) <==> MEKK1(h):MEKK1(h) (binding) | MEKK1(h) --> Atf3(m) (transactivation) | Abl(h) + MEKK1(h) <==> Abl(h):MEKK1(h) (binding) | MEKK1(h) + Abl(h) <==> MEKK1(h):Abl(h) (binding) | GSK3beta(h) + MEKK1(h) <==> GSK3beta(h):MEKK1(h) (binding) | MEKK1(h) --> protein remnants + MEKK1-p100(h) (cleavage) | PKCdelta(h) + MEKK1(h) <==> PKCdelta(h):MEKK1(h) (binding) | MAP3K1(h) --> MEKK1(h) (expression). | IKK-beta(h) + ATP --MEKK1(h)--> IKK-beta(h){p} + ADP (phosphorylation) | IKK-alpha(h) + ATP --MEKK1(h)--> IKK-alpha(h){p} + ADP (phosphorylation) | MKK4(m) + ATP --MEKK1(h)--> MKK4(m){p} + ADP (phosphorylation) | MAP3K1(h) --> MEKK1(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 1383 | Phosphothreonine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 1395 | Phosphothreonine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for MAP3K1 | ||