| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4214 |
Name | MAP3K1 |
Synonym | MAPKKK1|MEKK|MEKK 1|MEKK1|SRXY6;mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase;MAP3K1;mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase |
Definition | MAP/ERK kinase kinase 1|MAPK/ERK kinase kinase 1|MEK kinase 1|mitogen-activated protein kinase kinase kinase 1 |
Position | 5q11.2 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | CDC42 signaling events;PID Curated;200057 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | rac1 cell motility signaling pathway;PID BioCarta;100056 |
Pathway | RIG-I-like receptor signaling pathway;KEGG PATHWAY;hsa04622 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes;PID Curated;200076 |
Pathway | pdgf signaling pathway;PID BioCarta;100077 |
Pathway | Osteopontin-mediated events;PID Curated;200042 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | human cytomegalovirus and map kinase pathways;PID BioCarta;100149 |
Pathway | TNF receptor signaling pathway;PID Curated;200086 |
Pathway | mapkinase signaling pathway;PID BioCarta;100113 |
Pathway | Caspase cascade in apoptosis;PID Curated;200148 |
Pathway | tnfr2 signaling pathway;PID BioCarta;100014 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | hiv-1 nef: negative effector of fas and tnf;PID BioCarta;100144 |
Pathway | egf signaling pathway;PID BioCarta;100181 |
Pathway | TRAIL signaling pathway;PID Curated;200056 |
Pathway | CD40/CD40L signaling;PID Curated;200031 |
Pathway | nf-kb signaling pathway;PID BioCarta;100097 |
Pathway | Ras Pathway;PANTHER;P04393 |
Pathway | IFN-gamma pathway;PID Curated;200110 |
Pathway | inhibition of cellular proliferation by gleevec;PID BioCarta;100154 |
Pathway | map kinase inactivation of smrt corepressor;PID BioCarta;100032 |
Pathway | signal transduction through il1r;PID BioCarta;100132 |
Pathway | fas signaling pathway (cd95);PID BioCarta;100167 |
Pathway | JNK signaling in the CD4+ TCR pathway;PID Curated;200129 |
Pathway | p38 mapk signaling pathway;PID BioCarta;100085 |
Pathway | keratinocyte differentiation;PID BioCarta;100119 |
Pathway | toll-like receptor pathway;PID BioCarta;100013 |
Pathway | links between pyk2 and map kinases;PID BioCarta;100057 |
Pathway | cd40l signaling pathway;PID BioCarta;100213 |
Pathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling;PID BioCarta;100236 |
Pathway | bcr signaling pathway;PID BioCarta;100227 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | t cell receptor signaling pathway;PID BioCarta;100022 |
Pathway | MyD88 cascade;PID Reactome;500445 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | fc epsilon receptor i signaling in mast cells;PID BioCarta;100165 |
Pathway | role of mal in rho-mediated activation of srf;PID BioCarta;100114 |
Pathway | p38 MAPK signaling pathway;PID Curated;200014 |
Pathway | Ceramide signaling pathway;PID Curated;200100 |
Pathway | tnf/stress related signaling;PID BioCarta;100026 |
Pathway | RAC1 signaling pathway;PID Curated;200190 |
Pathway | ceramide signaling pathway;PID BioCarta;100206 |
Pathway | Regulation of cytoplasmic and nuclear SMAD2/3 signaling;PID Curated;200152 |
Pathway | FAS (CD95) signaling pathway;PID Curated;200067 |
Disease | Breast cancer;NHGRI |
Disease | breast cancer;GAD |
Disease | CANCER;GAD |
Disease | Cancer;FunDO |
Disease | Diabetes mellitus;FunDO |
External Links | |
Links to Entrez Gene | 4214 |
Links to all GeneRIF Items | 4214 |
Links to iHOP | 4214 |
Sequence Information | |
Nucleotide Sequence | >4214 : length: 7522 CACCAGAAACCCAAGTTGGAACTAATTCTTTCTTTCGGAAGGTGCAACTCCCCTCCCGCG AGCTCCGCGGTGCCGGGCCGAGATTGCCGAGAGGAAGCGGCGCAGCGCTGCCGCCAAGGC TCCTCCTGTCGCCGGTGCGGCCGGGACTACCTGGCGGCGCGGCGCGTGCAGCGCGCAGAG TCCCGGGAGCCCACGCCTCCGCCTCCGCCCCCGCCCCCTCCGCCTCCCAGTCCACCTCGC CCGCCCGCCCTCTCGCCCGGCGGAGAGCACAGCCCACTCCCTCCCACCTGCGGCCGCCGG GCCGCCCTCCACCCACACCTCTGCCGCAGGCCGGACCCAGTGCGCCCGCCCGTCGGTCAG TCCAGGCCAGGCGCCCGGCGGGCCGCGCTCACGCAGTTGGCGCAGGAGGCCTTACGCTGG CGGCGCAGTGCCCGCCCCCTGCGCTCTCCCCGCCCCCTCCCTCCCTCGCAGGGGCCGAGC GAATGTAGCCCGCGAGAGAAAATGGCGGCGGCGGCGGGGAATCGCGCCTCGTCGTCGGGA TTCCCGGGCGCCAGGGCTACGAGCCCTGAGGCAGGCGGCGGCGGAGGAGCCCTCAAGGCG AGCAGCGCGCCCGCGGCTGCCGCGGGACTGCTGCGGGAGGCGGGCAGCGGGGGCCGCGAG CGGGCGGACTGGCGGCGGCGGCAGCTGCGCAAAGTGCGGAGTGTGGAGCTGGACCAGCTG CCTGAGCAGCCGCTCTTCCTTGCCGCCTCACCGCCGGCCTCCTCGACTTCCCCGTCGCCG GAGCCCGCGGACGCAGCGGGGAGTGGGACCGGCTTCCAGCCTGTGGCGGTGCCGCCGCCC CACGGAGCCGCGAGCCGCGGCGGCGCCCACCTTACCGAGTCGGTGGCGGCGCCGGACAGC GGCGCCTCGAGTCCCGCAGCGGCCGAGCCCGGGGAGAAGCGGGCGCCCGCCGCCGAGCCG TCTCCTGCAGCGGCCCCCGCCGGTCGTGAGATGGAGAATAAAGAAACTCTCAAAGGGTTG CACAAGATGGATGATCGTCCAGAGGAACGAATGATCAGGGAGAAACTGAAGGCAACCTGT ATGCCAGCCTGGAAGCACGAATGGTTGGAAAGGAGAAATAGGCGAGGGCCTGTGGTGGTA AAACCAATCCCAGTTAAAGGAGATGGATCTGAAATGAATCACTTAGCAGCTGAGTCTCCA GGAGAGGTCCAGGCAAGTGCGGCTTCACCAGCTTCCAAAGGCCGACGCAGTCCTTCTCCT GGCAACTCCCCATCAGGTCGCACAGTGAAATCAGAATCTCCAGGAGTAAGGAGAAAAAGA GTTTCCCCAGTGCCTTTTCAGAGTGGCAGAATCACACCACCCCGAAGAGCCCCTTCACCA GATGGCTTCTCACCATATAGCCCTGAGGAAACAAACCGCCGTGTTAACAAAGTGATGCGG GCCAGACTGTACTTACTGCAGCAGATAGGGCCTAACTCTTTCCTGATTGGAGGAGACAGC CCAGACAATAAATACCGGGTGTTTATTGGGCCTCAGAACTGCAGCTGTGCACGTGGAACA TTCTGTATTCATCTGCTATTTGTGATGCTCCGGGTGTTTCAACTAGAACCTTCAGACCCA ATGTTATGGAGAAAAACTTTAAAGAATTTTGAGGTTGAGAGTTTGTTCCAGAAATATCAC AGTAGGCGTAGCTCAAGGATCAAAGCTCCATCTCGTAACACCATCCAGAAGTTTGTTTCA CGCATGTCAAATTCTCATACATTGTCATCATCTAGTACTTCTACGTCTAGTTCAGAAAAC AGCATAAAGGATGAAGAGGAACAGATGTGTCCTATTTGCTTGTTGGGCATGCTTGATGAA GAAAGTCTTACAGTGTGTGAAGACGGCTGCAGGAACAAGCTGCACCACCACTGCATGTCA ATTTGGGCAGAAGAGTGTAGAAGAAATAGAGAACCTTTAATATGTCCCCTTTGTAGATCT AAGTGGAGATCTCATGATTTCTACAGCCACGAGTTGTCAAGTCCTGTGGATTCCCCTTCT TCCCTCAGAGCTGCACAGCAGCAAACCGTACAGCAGCAGCCTTTGGCTGGATCACGAAGG AATCAAGAGAGCAATTTTAACCTTACTCATTATGGAACTCAGCAAATCCCTCCTGCTTAC AAAGATTTAGCTGAGCCATGGATTCAGGTGTTTGGAATGGAACTCGTTGGCTGCTTATTT TCTAGAAACTGGAATGTGAGAGAGATGGCCCTCAGGCGTCTTTCCCATGATGTCAGTGGG GCCCTGCTGTTGGCAAATGGGGAGAGCACTGGAAATTCTGGGGGCAGCAGTGGAAGCAGC CCGAGTGGGGGAGCCACCAGTGGGTCTTCCCAGACCAGTATCTCAGGAGATGTGGTGGAG GCATGCTGCAGCGTTCTGTCAATGGTCTGTGCTGACCCTGTCTACAAAGTGTACGTTGCT GCTTTAAAAACATTGAGAGCCATGCTGGTATATACTCCTTGCCACAGTTTAGCGGAAAGA ATCAAACTTCAGAGACTTCTCCAGCCAGTTGTAGACACCATCCTAGTCAAATGTGCAGAT GCCAATAGCCGCACAAGTCAGCTGTCCATATCAACACTGTTGGAACTGTGCAAAGGCCAA GCAGGAGAGTTGGCAGTTGGCAGAGAAATACTAAAAGCTGGATCCATTGGTATTGGTGGT GTTGATTATGTCTTAAATTGTATTCTTGGAAACCAAACTGAATCAAACAATTGGCAAGAA CTTCTTGGCCGCCTTTGTCTTATAGATAGACTGTTGTTGGAATTTCCTGCTGAATTTTAT CCTCATATTGTCAGTACTGATGTTTCACAAGCTGAGCCTGTTGAAATCAGGTATAAGAAG CTGCTGTCCCTCTTAACCTTTGCTTTGCAGTCCATTGATAATTCCCACTCAATGGTTGGC AAACTTTCCAGAAGGATCTACTTGAGTTCTGCAAGAATGGTTACTACAGTACCCCATGTG TTTTCAAAACTGTTAGAAATGCTGAGTGTTTCCAGTTCCACTCACTTCACCAGGATGCGT CGCCGTTTGATGGCTATTGCAGATGAGGTGGAAATTGCCGAAGCCATCCAGTTGGGCGTA GAAGACACTTTGGATGGTCAACAGGACAGCTTCTTGCAGGCATCTGTTCCCAACAACTAT CTGGAAACCACAGAGAACAGTTCCCCTGAGTGCACAGTCCATTTAGAGAAAACTGGAAAA GGATTATGTGCTACAAAATTGAGTGCCAGTTCAGAGGACATTTCTGAGAGACTGGCCAGC ATTTCAGTAGGACCTTCTAGTTCAACAACAACAACAACAACAACAACAGAGCAACCAAAG CCAATGGTTCAAACAAAAGGCAGACCCCACAGTCAGTGTTTGAACTCCTCTCCTTTATCT CATCATTCCCAATTAATGTTTCCAGCCTTGTCAACCCCTTCTTCTTCTACCCCATCTGTA CCAGCTGGCACTGCAACAGATGTCTCTAAGCATAGACTTCAGGGATTCATTCCCTGCAGA ATACCTTCTGCATCTCCTCAAACACAGCGCAAGTTTTCTCTACAATTCCACAGAAACTGT CCTGAAAACAAAGACTCAGATAAACTTTCCCCAGTCTTTACTCAGTCAAGACCCTTGCCC TCCAGTAACATACACAGGCCAAAGCCATCTAGACCTACCCCAGGTAATACAAGTAAACAG GGAGATCCCTCAAAAAATAGCATGACACTTGATCTGAACAGTAGTTCCAAATGTGATGAC AGCTTTGGCTGTAGCAGCAATAGTAGTAATGCTGTTATACCCAGTGACGAGACAGTGTTC ACCCCAGTAGAGGAGAAATGCAGATTAGATGTCAATACAGAGCTCAACTCCAGTATTGAG GACCTTCTTGAAGCATCTATGCCTTCAAGTGATACAACAGTAACTTTTAAGTCAGAAGTT GCTGTCCTGTCTCCTGAAAAGGCTGAAAATGATGATACCTACAAAGATGATGTGAATCAT AATCAAAAGTGCAAAGAGAAGATGGAAGCTGAAGAAGAAGAAGCTTTAGCAATTGCCATG GCAATGTCAGCGTCTCAGGATGCCCTCCCCATAGTTCCTCAGCTGCAGGTTGAAAATGGA GAAGATATCATCATTATTCAACAGGATACACCAGAGACTCTACCAGGACATACCAAAGCA AAACAACCGTATAGAGAAGACACTGAATGGCTGAAAGGTCAACAGATAGGCCTTGGAGCA TTTTCTTCTTGTTATCAGGCTCAAGATGTGGGAACTGGAACTTTAATGGCTGTTAAACAG GTGACTTATGTCAGAAACACATCTTCTGAGCAAGAAGAAGTAGTAGAAGCACTAAGAGAA GAGATAAGAATGATGAGCCATCTGAATCATCCAAACATCATTAGGATGTTGGGAGCCACG TGTGAGAAGAGCAATTACAATCTCTTCATTGAATGGATGGCAGGGGGATCGGTGGCTCAT TTGCTGAGTAAATATGGAGCCTTCAAAGAATCAGTAGTTATTAACTACACTGAACAGTTA CTCCGTGGCCTTTCGTATCTCCATGAAAACCAAATCATTCACAGAGATGTCAAAGGTGCC AATTTGCTAATTGACAGCACTGGTCAGAGACTAAGAATTGCAGATTTTGGAGCTGCAGCC AGGTTGGCATCAAAAGGAACTGGTGCAGGAGAGTTTCAGGGACAATTACTGGGGACAATT GCATTTATGGCACCTGAGGTACTAAGAGGTCAACAGTATGGAAGGAGCTGTGATGTATGG AGTGTTGGCTGTGCTATTATAGAAATGGCTTGTGCAAAACCACCATGGAATGCAGAAAAA CACTCCAATCATCTTGCTTTGATATTTAAGATTGCTAGTGCAACTACTGCTCCATCGATC CCTTCACATTTGTCTCCTGGTTTACGAGATGTGGCTCTTCGTTGTTTAGAACTTCAACCT CAGGACAGACCTCCATCAAGAGAGCTACTGAAGCATCCAGTCTTTCGTACTACATGGTAG CCAATTATGCAGATCAACTACAGTAGAAACAGGATGCTCAACAAGAGAAAAAAAACTTGT GGGGAACCACATTGATATTCTACTGGCCATGATGCCACTGAACAGCTATGAACGAGGCCA GTGGGGAACCCTTACCTAAGTATGTGATTGACAAATCATGATCTGTACCTAAGCTCAGTA TGCAAAAGCCCAAACTAGTGCAGAAACTGTAAACTGTGCCTTTCAAAGAACTGGCCCTAG GTGAACAGGAAAACAATGAAGTTTGCATGACTAAATTGCAGAAGCATAATTTTATTTTTT TGGAGCACTTTTTCAGCAATATTAGCGGCTGAGGGGCTCAGGATCTATTTTAATATTTCA ATTATTCTTCCATTTCATATAGTGATCACAAGCAGGGGGTTCTGCAATTCCGTTCAAATT TTTTGTCACTGGCTATAAAATCAGTATCTGCCTCTTTTAGGTCAGAGTATGCTATGAGTA GCAATACATACATATATTTTTAAAAGTTGATACTTCTTTATGACCCACAGTTGACCTTTA TTTTCTTAAATACCAGGGCAGTTGTGGCTCATTGTGCATTTTACTGTTGGCCCATTCATT TCGTTTTTGGAAATTATGGTTTTGTATTTTCATGTTTATTTACATTCATTTTTGTTTATT CAGGGAAAGCTGATCTTTTTTTCAAACCAGAAAAAAAAAATGAACTAGATATGAAGTAGA GTTCATTAAATATCTTGCTATTGTCAGAGTTTTTAAAATATAGACTTAATTTTGTTTTTT TAAATTGGAATACAATAAAGTACTACCTACATTTGAGTCAGTCACCACTCTTATTGTGCA GGTTAAGTACAAGTTAACTAAAAATAAACTGTCCTCTCTGGTGCAACTCACAACCAAGAT CAAGATTACCTTAAAATTTATTTGAATTTTTTAGATGTTTTGGTTGTCAAACTGTAGGAA ACTTCACAACATTTAAGTCTTACTCTGTATGTAACAATCCATCATTCACCTTCACTACTG GTAGTAACATAGAGCTGCCATTTTCCTTTTACCATGCATCATCTCTTTACAGTAGGCCTG GCAGATCATTTTTTAAAAAGATTATTCAACTACCAATCAGTAATGTTTTTAAACAGTACA TTTGCTTTGAACTTGGAAAATGTGTTCAGAAAGAAAAATGGAATTGAATTTCATTTATAC ACTAATTCCTTGGATTTTGCACAGTTACCTAACGGTTTTAGTCTGGAGTTAAATTCAGAT GCATGGAATCCTGAAGGAAAATGGTAGCTTTTTAATCTTTTTGTGTGTGTGTGAGTCTTT TAAATCAAGTACTGATTAACTATTAAGTACAACTTTGAGATTTTAGTTTTAACTCTTCAG AAGCCAGTGTGAAATAGAATTGGTTATTCTCAAAGACTCAGGATAAACTAAATAAGCTAT ATATAGAGTACATTTAAAATGTACAACACAAATTGGAAATAAAATAAGTTACAAGATAAG TTTACAGGGATATATTGCTTACAATTTTTAAAAGGCAGTTTGTTTTTTATGTGAATATGT TTCTTAGTGAAATTTTACATTCCTTTGTTTTGGAAGATTGGCGATATTTGAAGAGTTAAA AATAGTACAGAAATGTGAAGTTTGGTATCTCTAAATGTGTTGTACTTGACTTTCTTTTTT ATTTTGTTTTTTTTTTTTTTTGACTACTTAGAATTTTCACAATTCTAATAAGATTGTTTC CAAGTCTCTCATGTGCAAGCTTTAAAGGATGCACTCTTGCCATTTTATGTACTGGAAGAT CATTGGTCAGATGAATACTGTGTCTGACAAAAATGTAAACTGTATAAACTGAGGAACCTC AGCTAATCAGTATTACTTTGTAGATCACCATGCCCACCACATTTCAAACTCAAACTATCT GTAGATTTCAAAATCCATTGTGTTTGAGTTTGTTTGCAGTTCCCTCAGCTTGCTGGTAAT TGTGGTGTTTTGTTTTTTGTTTTGTTTTCAATGCAAATGTGATGTAATATTCTTATTTTC TTTGGATCAAAGCTGGACTGGAAATTGTATCGTGTAATTATTTTTGTGTTCTTAATGTTA TTTGGTACTCAAGTTGTAAATAACGTCTACTACTGTTTATTCCAGTTTCTACTACCTCAG GTGTCCTATAGATTTTTCTTCTACCAAAGTTCACTTTCACAATGAAATTATATTTGCTGT GTGACTATGATTCCTAAGATTTCCAGGGCTTAAGGGCTAACTTCTATTAGCACCTTACTG TGTAAGCAAATGTTACAAAAAAAAAAAAAAAAAATCTCTGGGTTAAGAAAATTTGGCTTA AATGTATCCTTTGTTATTTTAAATATATTGAGATATTTTAATTAAAATTTTTACCCCATT GAACCGATTTTATAGTATTTGTACCTATTTTGGTGTTTTTGTCTTTATAGTAAATAAAAG TTTTTGAACAAAAAAAAAAAAA |
Protein Sequence | >4214 : length: 1512 MAAAAGNRASSSGFPGARATSPEAGGGGGALKASSAPAAAAGLLREAGSGGRERADWRRR QLRKVRSVELDQLPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRG GAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRP EERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASA ASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYS PEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLF VMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHT LSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECR RNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFN LTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANG ESTGNSGGSSGSSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRA MLVYTPCHSLAERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVG REILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTD VSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEM LSVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENS SPECTVHLEKTGKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKG RPHSQCLNSSPLSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQ TQRKFSLQFHRNCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNS MTLDLNSSSKCDDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASM PSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQD ALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQA QDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYN LFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDST GQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAII EMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSR ELLKHPVFRTTW |