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Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

4214

Name

MAP3K1

Synonymous

mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase;MAP3K1;mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase

Definition

MAP/ERK kinase kinase 1|MAPK/ERK kinase kinase 1|MEK kinase 1|mitogen-activated protein kinase kinase kinase 1

Position

5q11.2

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 AXIN1IMID;

in same component

 CD40LGNCI_NATURE;

in same component

 CD40NCI_NATURE;

in same component

 MAP3K14IMID;

in same component

 MAPK8IMID;

in same component

 MAVSREACTOME;

in same component

 TRAF2NCI_NATURE;

in same component

 TRAF6REACTOME;

interacts with

 AAT1INTACT;

interacts with

 ABCA9INTACT;

interacts with

 ABCB1INTACT;

interacts with

 ABRAINTACT;

interacts with

 ACACAINTACT;

interacts with

 ACACBINTACT;

interacts with

 ACTC1INTACT;

interacts with

 ACTG1MINT;

interacts with

 ADAMTS20INTACT;

interacts with

 ADNPINTACT;

interacts with

 AGKINTACT;

interacts with

 AGPAT1INTACT;

interacts with

 AHNAK2INTACT;

interacts with

 AHNAKINTACT;

interacts with

 AIFM1MINT;

interacts with

 AIFM2INTACT;

interacts with

 AJAP1INTACT;

interacts with

 ALKBIOGRID;

interacts with

 ALPK3INTACT;

interacts with

 ANKRD11INTACT;

interacts with

 ANLNINTACT;

interacts with

 AP4B1INTACT;

interacts with

 APAF1INTACT;

interacts with

 ARFGAP1INTACT;

interacts with

 ARG1INTACT;

interacts with

 ARID4BINTACT;

interacts with

 ARID5BINTACT;

interacts with

 ARMC1INTACT;

interacts with

 ASXL1INTACT;

interacts with

 ATMINTACT;

interacts with

 ATP5OINTACT;

interacts with

 ATP6V1DINTACT;

interacts with

 AXIN1BIOGRID;

interacts with

 BAG2MINT;

interacts with

 BAG3INTACT;

interacts with

 BAG5MINT;

interacts with

 BAHCC1INTACT;

interacts with

 BAZ1BINTACT;

interacts with

 BAZ2BINTACT;

interacts with

 BCMO1INTACT;

interacts with

 BDP1INTACT;

interacts with

 BIRC2HPRD;

interacts with

 BIRC3HPRD;

interacts with

 BPTFINTACT;

interacts with

 BRWD1INTACT;

interacts with

 BUB1INTACT;

interacts with

 C14orf43INTACT;

interacts with

 C20orf160INTACT;

interacts with

 C2orf16INTACT;

interacts with

 C2orf29INTACT;

interacts with

 C2orf89INTACT;

interacts with

 C4AINTACT;

interacts with

 CADMINT;

interacts with

 CALCOCO2INTACT;

interacts with

 CALD1INTACT;

interacts with

 CALM1MINT;

interacts with

 CBFBINTACT;

interacts with

 CCT3MINT;

interacts with

 CCT4MINT;

interacts with

 CCT5MINT;

interacts with

 CCT6AMINT;

interacts with

 CCT8MINT;

interacts with

 CD40HPRD;

interacts with

 CDC26INTACT;

interacts with

 CDC37BIOGRID;

interacts with

 CDC37MINT;

interacts with

 CDC42EP1INTACT;

interacts with

 CDK5RAP2INTACT;

interacts with

 CDV3INTACT;

interacts with

 CENPVINTACT;

interacts with

 CEP170INTACT;

interacts with

 CEP55INTACT;

interacts with

 CFL1INTACT;

interacts with

 CHAF1BINTACT;

interacts with

 CKAP4INTACT;

interacts with

 CLEC11AINTACT;

interacts with

 CLSTN1INTACT;

interacts with

 CNOT4INTACT;

interacts with

 CNTN5INTACT;

interacts with

 CPSF2INTACT;

interacts with

 CROCCINTACT;

interacts with

 CSF1INTACT;

interacts with

 CTBP1INTACT;

interacts with

 CTR9INTACT;

interacts with

 CYBAINTACT;

interacts with

 CYP2U1INTACT;

interacts with

 DACT1INTACT;

interacts with

 DCAF7BIOGRID;

interacts with

 DCAF7MINT;

interacts with

 DDB1MINT;

interacts with

 DDX24INTACT;

interacts with

 DDX47INTACT;

interacts with

 DDX51INTACT;

interacts with

 DENND3INTACT;

interacts with

 DHX30INTACT;

interacts with

 DHX58INTACT;

interacts with

 DHX9MINT;

interacts with

 DIP2BINTACT;

interacts with

 DIRAS2INTACT;

interacts with

 DNAJA1MINT;

interacts with

 DNAJA3MINT;

interacts with

 DNAJB12INTACT;

interacts with

 DNMT1INTACT;

interacts with

 DPM1INTACT;

interacts with

 DTX1BIOGRID;

interacts with

 DUSP15INTACT;

interacts with

 DVL2BIOGRID;

interacts with

 DYNC1LI1INTACT;

interacts with

 DYNLRB1INTACT;

interacts with

 EEF1A2MINT;

interacts with

 EHHADHINTACT;

interacts with

 ELFN1INTACT;

interacts with

 EP400INTACT;

interacts with

 EPC1INTACT;

interacts with

 EPPK1MINT;

interacts with

 ERBB2IPINTACT;

interacts with

 ERBB4INTACT;

interacts with

 ERP44INTACT;

interacts with

 ESR1MINT;

interacts with

 ETV3INTACT;

interacts with

 ETV6INTACT;

interacts with

 EXOSC1INTACT;

interacts with

 FAF2INTACT;

interacts with

 FAM116BINTACT;

interacts with

 FAM117BINTACT;

interacts with

 FANCCINTACT;

interacts with

 FANCMINTACT;

interacts with

 FASNMINT;

interacts with

 FASTKD1INTACT;

interacts with

 FERMT3INTACT;

interacts with

 FKBP5BIOGRID;

interacts with

 FKBP5MINT;

interacts with

 FLNAMINT;

interacts with

 FLNBMINT;

interacts with

 FN1INTACT;

interacts with

 FOSL2INTACT;

interacts with

 FOXC2INTACT;

interacts with

 FRMD6INTACT;

interacts with

 FRMPD4INTACT;

interacts with

 FZR1INTACT;

interacts with

 GABRR1INTACT;

interacts with

 GEMIN4MINT;

interacts with

 GFPT1INTACT;

interacts with

 GLTSCR1INTACT;

interacts with

 GLUD1MINT;

interacts with

 GPR158INTACT;

interacts with

 GRHL2INTACT;

interacts with

 GSK3BINTACT;

interacts with

 GTF3C4INTACT;

interacts with

 HADHAMINT;

interacts with

 HADHBINTACT;

interacts with

 HADHBMINT;

interacts with

 HCFC2INTACT;

interacts with

 HIRAINTACT;

interacts with

 HIST1H1AINTACT;

interacts with

 HIST1H2ABINTACT;

interacts with

 HIST1H2BMINTACT;

interacts with

 HK1INTACT;

interacts with

 HNRNPCINTACT;

interacts with

 HNRNPMMINT;

interacts with

 HOXA10INTACT;

interacts with

 HOXB5INTACT;

interacts with

 HSD17B4INTACT;

interacts with

 HSP90AA1MINT;

interacts with

 HSP90AB1MINT;

interacts with

 HSPA1LMINT;

interacts with

 HSPA5MINT;

interacts with

 HSPA6MINT;

interacts with

 HSPA8MINT;

interacts with

 HSPA9MINT;

interacts with

 HSPB1INTACT;

interacts with

 HSPBP1MINT;

interacts with

 HSPH1MINT;

interacts with

 IGF2BP2INTACT;

interacts with

 IKBKBBIOGRID;

interacts with

 IL16INTACT;

interacts with

 IL1BINTACT;

interacts with

 IMMTINTACT;

interacts with

 INSM1INTACT;

interacts with

 IRS4MINT;

interacts with

 ITCHINTACT;

interacts with

 JAK1INTACT;

interacts with

 JAK2INTACT;

interacts with

 JUNINTACT;

interacts with

 KALRNINTACT;

interacts with

 KANK2INTACT;

interacts with

 KARSINTACT;

interacts with

 KAT2AINTACT;

interacts with

 KCNG3INTACT;

interacts with

 KIAA0319INTACT;

interacts with

 KIAA0922INTACT;

interacts with

 KIAA2026INTACT;

interacts with

 KIF12INTACT;

interacts with

 KIF20BINTACT;

interacts with

 LATS2INTACT;

interacts with

 LBX2INTACT;

interacts with

 LCN12INTACT;

interacts with

 LGALS1INTACT;

interacts with

 LGALS3BPMINT;

interacts with

 LGALS7INTACT;

interacts with

 LIMS1INTACT;

interacts with

 LMO7INTACT;

interacts with

 LOXINTACT;

interacts with

 LRP1BINTACT;

interacts with

 MAGEB10INTACT;

interacts with

 MAGI1INTACT;

interacts with

 MAP1AINTACT;

interacts with

 MAP2K1BIOGRID;

interacts with

 MAP2K1MINT;

interacts with

 MAP2K4BIOGRID;

interacts with

 MAP2K4HPRD;

interacts with

 MAP2K7MINT;

interacts with

 MAP3K4MINT;

interacts with

 MAP3K5INTACT;

interacts with

 MAP3K7HPRD;

interacts with

 MAP3K7INTACT;

interacts with

 MAP4K2BIOGRID;

interacts with

 MAP4K4BIOGRID;

interacts with

 MAP7D1INTACT;

interacts with

 MAPK1BIOGRID;

interacts with

 MAPK1HPRD;

interacts with

 MAPK8IP3BIOGRID;

interacts with

 MAPK8BIOGRID;

interacts with

 MARSMINT;

interacts with

 MAST4INTACT;

interacts with

 MATN4INTACT;

interacts with

 MAXINTACT;

interacts with

 MCF2L2INTACT;

interacts with

 MCM4INTACT;

interacts with

 MCTP2INTACT;

interacts with

 MED12LINTACT;

interacts with

 MED1INTACT;

interacts with

 MFHAS1INTACT;

interacts with

 MIB1INTACT;

interacts with

 MLL5INTACT;

interacts with

 MLLINTACT;

interacts with

 MRGBPINTACT;

interacts with

 MRPL14INTACT;

interacts with

 MTRF1INTACT;

interacts with

 MYCINTACT;

interacts with

 MYH10MINT;

interacts with

 MYLK2MINT;

interacts with

 MYO18AINTACT;

interacts with

 MYO1DINTACT;

interacts with

 MYO1DMINT;

interacts with

 NAIPINTACT;

interacts with

 NAV3INTACT;

interacts with

 NCLMINT;

interacts with

 NCOR1INTACT;

interacts with

 NCOR2INTACT;

interacts with

 NFIL3INTACT;

interacts with

 NOP2MINT;

interacts with

 NPR1INTACT;

interacts with

 NPTX2INTACT;

interacts with

 NRD1INTACT;

interacts with

 NSD1INTACT;

interacts with

 NUP98INTACT;

interacts with

 OBSCNINTACT;

interacts with

 ODZ2INTACT;

interacts with

 OPHN1INTACT;

interacts with

 OTUD4INTACT;

interacts with

 PADI2INTACT;

interacts with

 PALDINTACT;

interacts with

 PARP1INTACT;

interacts with

 PCBP2INTACT;

interacts with

 PDHA2INTACT;

interacts with

 PDLIM4INTACT;

interacts with

 PDS5BINTACT;

interacts with

 PFDN2INTACT;

interacts with

 PGDINTACT;

interacts with

 PHF6INTACT;

interacts with

 PHKA1INTACT;

interacts with

 PIK3CGINTACT;

interacts with

 PITX2INTACT;

interacts with

 PKD1L3INTACT;

interacts with

 PKM2INTACT;

interacts with

 PLA2G4AINTACT;

interacts with

 PLEKHH1INTACT;

interacts with

 PLOD2INTACT;

interacts with

 POLGINTACT;

interacts with

 POLR3AINTACT;

interacts with

 POP4INTACT;

interacts with

 PPA2INTACT;

interacts with

 PPEF2INTACT;

interacts with

 PPIP5K2INTACT;

interacts with

 PPP2R3BINTACT;

interacts with

 PREX2INTACT;

interacts with

 PRG4INTACT;

interacts with

 PRKAR1BINTACT;

interacts with

 PRKCDBPINTACT;

interacts with

 PRR11INTACT;

interacts with

 PRRC2AINTACT;

interacts with

 PSMA3INTACT;

interacts with

 PSMC1INTACT;

interacts with

 PSMD2INTACT;

interacts with

 PTBP1INTACT;

interacts with

 QPCTLINTACT;

interacts with

 RAB11FIP5INTACT;

interacts with

 RAC1MINT;

interacts with

 RAD50INTACT;

interacts with

 RAF1BIOGRID;

interacts with

 RAF1HPRD;

interacts with

 RAG1INTACT;

interacts with

 RALGAPA1INTACT;

interacts with

 RARAINTACT;

interacts with

 RBFAINTACT;

interacts with

 RBFOX2INTACT;

interacts with

 RBM10INTACT;

interacts with

 RBM39INTACT;

interacts with

 RCN2MINT;

interacts with

 RFX7INTACT;

interacts with

 RIMS2INTACT;

interacts with

 RPL10MINT;

interacts with

 RPL13MINT;

interacts with

 RPL14MINT;

interacts with

 RPL18MINT;

interacts with

 RPL26L1INTACT;

interacts with

 RPL35AMINT;

interacts with

 RPL35MINT;

interacts with

 RPL3MINT;

interacts with

 RPL4BIOGRID;

interacts with

 RPL4MINT;

interacts with

 RPL7MINT;

interacts with

 RPLP0P6MINT;

interacts with

 RPLP2MINT;

interacts with

 RPP30INTACT;

interacts with

 RPRD2INTACT;

interacts with

 RPS21INTACT;

interacts with

 RPS27LINTACT;

interacts with

 RPS27LMINT;

interacts with

 RPS27MINT;

interacts with

 RPS2INTACT;

interacts with

 RPS9MINT;

interacts with

 RRM1INTACT;

interacts with

 RRP1BINTACT;

interacts with

 RSF1INTACT;

interacts with

 RUNX2INTACT;

interacts with

 RUVBL2MINT;

interacts with

 SACSINTACT;

interacts with

 SAMD9LINTACT;

interacts with

 SBNO2INTACT;

interacts with

 SDF4INTACT;

interacts with

 SDHAINTACT;

interacts with

 SEC11CINTACT;

interacts with

 SERPINH1INTACT;

interacts with

 SETD2INTACT;

interacts with

 SETXINTACT;

interacts with

 SGOL2INTACT;

interacts with

 SH3RF1INTACT;

interacts with

 SHANK2INTACT;

interacts with

 SHEINTACT;

interacts with

 SIPA1L3INTACT;

interacts with

 SLC1A5MINT;

interacts with

 SLC25A10INTACT;

interacts with

 SLC25A5MINT;

interacts with

 SLC25A6MINT;

interacts with

 SMARCA5INTACT;

interacts with

 SMC6INTACT;

interacts with

 SMTNINTACT;

interacts with

 SMYD4INTACT;

interacts with

 SNX19INTACT;

interacts with

 SQRDLINTACT;

interacts with

 SSR4MINT;

interacts with

 ST6GALNAC6INTACT;

interacts with

 SUCLG1INTACT;

interacts with

 SUCLG2INTACT;

interacts with

 SYNE1INTACT;

interacts with

 TAF2INTACT;

interacts with

 TAF5LINTACT;

interacts with

 TBL2INTACT;

interacts with

 TCP1MINT;

interacts with

 TDGINTACT;

interacts with

 TENC1INTACT;

interacts with

 TEX2INTACT;

interacts with

 TIMM50MINT;

interacts with

 TMPRSS11AINTACT;

interacts with

 TNPO1INTACT;

interacts with

 TNRINTACT;

interacts with

 TPH1INTACT;

interacts with

 TPP1INTACT;

interacts with

 TRAF2BIOGRID;

interacts with

 TRAF2HPRD;

interacts with

 TRAK1INTACT;

interacts with

 TRAP1INTACT;

interacts with

 TRIP11INTACT;

interacts with

 TRRAPINTACT;

interacts with

 TSHZ1INTACT;

interacts with

 TUBA1AMINT;

interacts with

 TUBA3CMINT;

interacts with

 TUBA4AINTACT;

interacts with

 TUBB2BMINT;

interacts with

 TUBB3INTACT;

interacts with

 TUBB4MINT;

interacts with

 TUBB6INTACT;

interacts with

 TUBB6MINT;

interacts with

 TUBB8MINT;

interacts with

 TUBBMINT;

interacts with

 TUFMINTACT;

interacts with

 TXNINTACT;

interacts with

 UBA1INTACT;

interacts with

 UBE2D1BIOGRID;

interacts with

 UBE2D2BIOGRID;

interacts with

 UBE2D3BIOGRID;

interacts with

 UBE2D4BIOGRID;

interacts with

 UBE2E1BIOGRID;

interacts with

 UBE2IBIOGRID;

interacts with

 UBE2L6BIOGRID;

interacts with

 UBE2NHPRD;

interacts with

 UBE2WBIOGRID;

interacts with

 UBTFINTACT;

interacts with

 UQCRFS1INTACT;

interacts with

 USP10INTACT;

interacts with

 USP36INTACT;

interacts with

 USP48INTACT;

interacts with

 USP9XMINT;

interacts with

 VIMMINT;

interacts with

 WDFY3INTACT;

interacts with

 WDR7INTACT;

interacts with

 WIPF1INTACT;

interacts with

 XKRXINTACT;

interacts with

 XYLT1INTACT;

interacts with

 YAF2INTACT;

interacts with

 YWHAEBIOGRID;

interacts with

 YWHAEMINT;

interacts with

 ZBTB40INTACT;

interacts with

 ZC3H18INTACT;

interacts with

 ZC3H7BINTACT;

interacts with

 ZFHX3INTACT;

interacts with

 ZFP106INTACT;

interacts with

 ZNF238INTACT;

interacts with

 ZNF354BINTACT;

interacts with

 ZNF541INTACT;

interacts with

 ZNF586INTACT;

interacts with

 ZNF703INTACT;

interacts with

 ZNF740INTACT;

interacts with

 ZZEF1INTACT;

Metabolic Interaction   [Top]

There is no record for MAP3K1

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 AXIN1IMID;

reacts with

 CD40LGNCI_NATURE;

reacts with

 CD40NCI_NATURE;

reacts with

 MAP3K14IMID;

reacts with

 MAP3K1IMID;

reacts with

 MAP3K1NCI_NATURE;

reacts with

 MAP3K1REACTOME;

reacts with

 MAPK8IMID;

reacts with

 MAVSREACTOME;

reacts with

 TRAF2NCI_NATURE;

reacts with

 TRAF6REACTOME;

state change

 CDC42NCI_NATURE;

state change

 DAPP1NCI_NATURE;

state change

 DBNLNCI_NATURE;

state change

 ECSITREACTOME;

state change

 FADDNCI_NATURE;

state change

 GRAP2NCI_NATURE;

state change

 IFNGNCI_NATURE;

state change

 IFNGR1NCI_NATURE;

state change

 ITGAVNCI_NATURE;

state change

 ITGB3NCI_NATURE;

state change

 JAK1NCI_NATURE;

state change

 JAK2NCI_NATURE;

state change

 LCP2NCI_NATURE;

state change

 MAP3K11NCI_NATURE;

state change

 MAP3K7NCI_NATURE;

state change

 MAP4K1NCI_NATURE;

state change

 PAK2NCI_NATURE;

state change

 RAC1NCI_NATURE;

state change

 RIPK1NCI_NATURE;

state change

 SPP1NCI_NATURE;

state change

 TNFRSF10ANCI_NATURE;

state change

 TNFRSF10BNCI_NATURE;

state change

 TNFSF10NCI_NATURE;

state change

 TRADDNCI_NATURE;

state change

 TRAF2NCI_NATURE;

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