| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 9146 |
Name | HGS |
Synonymous | hepatocyte growth factor-regulated tyrosine kinase substrate;HGS;hepatocyte growth factor-regulated tyrosine kinase substrate |
Definition | human growth factor-regulated tyrosine kinase substrate|protein pp110 |
Position | 17q25 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | HRS(h) + TAK1(h) <==> HRS(h):TAK1(h) (binding) | HRS(h) + p65PAK(h) <==> HRS(h):p65PAK(h) (binding) | HRS(h) + ATP --> HRS(h){pY} + ADP (phosphorylation) | ErbB1(h){ub} + HRS(h) <==> ErbB1(h){ub}:HRS(h) (binding) | Keratin-18(h) + HRS(h) <==> Keratin-18(h):HRS(h) (binding) | Keratin-19(h) + HRS(h) <==> Keratin-19(h):HRS(h) (binding) | ADA2(h) + HRS(h) <==> ADA2(h):HRS(h) (binding) | TSG101(h) + HRS(h) <==> TSG101(h):HRS(h) (binding) | Ubc9(h) + HRS(h) <==> Ubc9(h):HRS(h) (binding) | STAM(h) + HRS(h) <==> STAM(h):HRS(h) (binding) | Nmi(h) + HRS(h) <==> Nmi(h):HRS(h) (binding) | HRS(h) + MED7(h) <==> HRS(h):MED7(h) (binding) | HRS(h) + dazap2(h) <==> HRS(h):dazap2(h) (binding) | HRS(h) + STAM2(h) <==> HRS(h):STAM2(h) (binding) | HRS(h) + G9A(h) <==> HRS(h):G9A(h) (binding) | HRS(h) + EXO70(h) <==> HRS(h):EXO70(h) (binding) | HRS(h) + BCUR1(h) <==> HRS(h):BCUR1(h) (binding) | HRS(h) + ubiquilin1(h) <==> HRS(h):ubiquilin1(h) (binding) | HRS(h) + MIFD(h) <==> HRS(h):MIFD(h) (binding) | HRS(h) + begain(h) <==> HRS(h):begain(h) (binding) | HRS(h) + gkap1(h) <==> HRS(h):gkap1(h) (binding) | HRS(h) + ushbp1(h) <==> HRS(h):ushbp1(h) (binding) | HRS(h) + exoc8(h) <==> HRS(h):exoc8(h) (binding) | HRS(h) + c1orf190(h) <==> HRS(h):c1orf190(h) (binding) | HRS(h) + MNAR-isoform2(h) <==> HRS(h):MNAR-isoform2(h) (binding) | HRS(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation) | HRS(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | IL-2Rbeta(h) + HRS(h) <==> IL-2Rbeta(h):HRS(h) (binding) | HRS(h) + Smad5(h) <==> HRS(h):Smad5(h) (binding) | Trak1(h) + HRS(h) <==> Trak1(h):HRS(h) (binding) | eps15(h) + HRS(h) <==> eps15(h):HRS(h) (binding) | HGS(h) --> HRS(h) (expression). | UBPY(h) --> HRS(h) (increase of abundance) | MNAR(h) + HRS-isoform1(h) <==> MNAR(h):HRS-isoform1(h) (binding) | HRS-isoform1(h) --> AKT(h){p} (increase of phosphorylation) | HRS-isoform1(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation) | HRS-isoform1(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | HRS-isoform1(h) --> ERK1(mo){p}2 (increase of phosphorylation) | HRS-isoform1(h) --> ERK2(mo){p}2 (increase of phosphorylation) | HGS(h) --> HRS-isoform1(h) (expression). | HGS(h) --> HRS-isoform2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 216 | Phosphotyrosine. | Swiss-Prot 53.0 | 308 | Phosphotyrosine. | Swiss-Prot 53.0 | 329 | Phosphotyrosine (By similarity). | Swiss-Prot 53.0 | 334 | Phosphotyrosine (By similarity). | Swiss-Prot 53.0 | 334 | Phosphotyrosine | 11687594;12953068 | Phospho.ELM 6.0 | 329 | Phosphotyrosine (EGFR) | 12953068 | Phospho.ELM 6.0 | 216 | Phosphotyrosine | 15592455 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr17 |
Promoter: 77259925 - 77261925 | Agilent_014791 |
chr17 |
Promoter: 77259925 - 77261925 | GSE27584 |