Entrez Gene

Basic Information
Gene ID	9146
Name	HGS
Synonymous	hepatocyte growth factor-regulated tyrosine kinase substrate;HGS;hepatocyte growth factor-regulated tyrosine kinase substrate
Definition	human growth factor-regulated tyrosine kinase substrate\|protein pp110
Position	17q25
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.866A>C; p.Y289S; 17:81693895-81693895	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.1465G>A; p.E489K; 17:81696428-81696428	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1384G>A; p.E462K; 17:81695990-81695990	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1233G>A; p.A411A; 17:81695839-81695839	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1102C>T; p.P368S; 17:81695050-81695050	skin	malignant_melanoma	Substitution - Missense
c.1966G>A; p.A656T; 17:81700550-81700550	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1966G>A; p.A656T; 17:81700550-81700550	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.143C>T; p.S48F; 17:81686332-81686332	skin	malignant_melanoma	Substitution - Missense
c.1987T>C; p.Y663H; 17:81700571-81700571	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1138G>A; p.D380N; 17:81695182-81695182	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2196C>T; p.I732I; 17:81701104-81701104	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1771A>T; p.S591C; 17:81696887-81696887	skin	malignant_melanoma	Substitution - Missense
c.1258G>A; p.V420M; 17:81695864-81695864	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.14G>T; p.S5I; 17:81684080-81684080	skin	malignant_melanoma	Substitution - Missense
c.1323A>T; p.S441S; 17:81695929-81695929	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.592T>C; p.S198P; 17:81691501-81691501	skin	malignant_melanoma	Substitution - Missense
c.2007G>A; p.A669A; 17:81700591-81700591	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.704C>T; p.P235L; 17:81693544-81693544	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2198C>T; p.A733V; 17:81701106-81701106	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.890C>T; p.S297L; 17:81693919-81693919	breast	carcinoma	Substitution - Missense
c.1826T>C; p.M609T; 17:81696942-81696942	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.901G>T; p.A301S; 17:81693930-81693930	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1232C>T; p.A411V; 17:81695838-81695838	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1179G>A; p.E393E; 17:81695223-81695223	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.34C>A; p.L12I; 17:81684100-81684100	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1637G>A; p.R546Q; 17:81696677-81696677	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2168C>T; p.A723V; 17:81701076-81701076	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.995G>A; p.R332Q; 17:81694943-81694943	pancreas	carcinoma	Substitution - Missense
c.1637G>A; p.R546Q; 17:81696677-81696677	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.348G>A; p.A116A; 17:81688760-81688760	pancreas	carcinoma	Substitution - coding silent
c.342C>T; p.A114A; 17:81688754-81688754	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.347C>T; p.A116V; 17:81688759-81688759	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.347C>T; p.A116V; 17:81688759-81688759	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1257C>T; p.F419F; 17:81695863-81695863	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1689delC; p.L565fs*45; 17:81696729-81696729	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1487G>A; p.R496H; 17:81696450-81696450	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2102C>T; p.S701L; 17:81700780-81700780	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1310C>T; p.S437L; 17:81695916-81695916	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.255C>T; p.N85N; 17:81687059-81687059	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1322C>T; p.S441L; 17:81695928-81695928	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1765T>G; p.F589V; 17:81696881-81696881	breast	carcinoma	Substitution - Missense
c.1122C>A; p.N374K; 17:81695166-81695166	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.445G>A; p.D149N; 17:81690211-81690211	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.445G>A; p.D149N; 17:81690211-81690211	central_nervous_system; brain	glioma	Substitution - Missense
c.1122C>A; p.N374K; 17:81695166-81695166	stomach	adenocarcinoma	Substitution - Missense
c.44C>T; p.A15V; 17:81685611-81685611	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.418C>A; p.H140N; 17:81690184-81690184	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.854C>T; p.T285M; 17:81693883-81693883	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.1810A>G; p.M604V; 17:81696926-81696926	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.854C>T; p.T285M; 17:81693883-81693883	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1571A>G; p.Y524C; 17:81696611-81696611	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1470G>T; p.E490D; 17:81696433-81696433	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1346T>C; p.M449T; 17:81695952-81695952	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.1029C>T; p.R343R; 17:81694977-81694977	breast	carcinoma	Substitution - coding silent
c.1089A>G; p.E363E; 17:81695037-81695037	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1942C>T; p.P648S; 17:81700526-81700526	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.152A>G; p.K51R; 17:81686341-81686341	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.152A>G; p.K51R; 17:81686341-81686341	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.152A>G; p.K51R; 17:81686341-81686341	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1545G>T; p.E515D; 17:81696508-81696508	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.152A>G; p.K51R; 17:81686341-81686341	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.363C>T; p.N121N; 17:81688775-81688775	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2140C>G; p.L714V; 17:81701048-81701048	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1767C>T; p.F589F; 17:81696883-81696883	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2238C>T; p.G746G; 17:81701522-81701522	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2238C>T; p.G746G; 17:81701522-81701522	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2238C>T; p.G746G; 17:81701522-81701522	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2238C>T; p.G746G; 17:81701522-81701522	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2238C>T; p.G746G; 17:81701522-81701522	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.151A>G; p.K51E; 17:81686340-81686340	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.151A>G; p.K51E; 17:81686340-81686340	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2305A>G; p.S769G; 17:81701589-81701589	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.649G>C; p.E217Q; 17:81691558-81691558	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1350C>T; p.H450H; 17:81695956-81695956	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2142C>T; p.L714L; 17:81701050-81701050	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2140C>T; p.L714F; 17:81701048-81701048	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1974C>T; p.P658P; 17:81700558-81700558	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.181G>T; p.A61S; 17:81686370-81686370	breast	carcinoma	Substitution - Missense
c.849G>C; p.K283N; 17:81693878-81693878	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.849G>C; p.K283N; 17:81693878-81693878	urinary_tract; bladder	carcinoma	Substitution - Missense
c.153G>A; p.K51K; 17:81686342-81686342	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.153G>A; p.K51K; 17:81686342-81686342	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.958G>A; p.E320K; 17:81694836-81694836	breast	carcinoma	Substitution - Missense
c.1819G>A; p.V607M; 17:81696935-81696935	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1063A>G; p.T355A; 17:81695011-81695011	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1604G>A; p.R535H; 17:81696644-81696644	breast	carcinoma	Substitution - Missense
c.910G>A; p.A304T; 17:81693939-81693939	pancreas	carcinoma	Substitution - Missense
c.947C>A; p.A316E; 17:81694825-81694825	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1034G>A; p.S345N; 17:81694982-81694982	breast	carcinoma	Substitution - Missense
c.891G>T; p.S297S; 17:81693920-81693920	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1928G>T; p.G643V; 17:81700512-81700512	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1095C>T; p.H365H; 17:81695043-81695043	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.955G>A; p.A319T; 17:81694833-81694833	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1285C>T; p.R429W; 17:81695891-81695891	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.109C>T; p.Q37*; 17:81685676-81685676	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Nonsense
c.109C>T; p.Q37*; 17:81685676-81685676	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Nonsense
c.177C>T; p.H59H; 17:81686366-81686366	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.177C>T; p.H59H; 17:81686366-81686366	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.177C>T; p.H59H; 17:81686366-81686366	central_nervous_system; brain	glioma	Substitution - coding silent
c.423C>A; p.V141V; 17:81690189-81690189	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1066G>A; p.E356K; 17:81695014-81695014	skin	malignant_melanoma	Substitution - Missense
c.983G>A; p.R328Q; 17:81694931-81694931	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1684G>A; p.A562T; 17:81696724-81696724	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1387C>T; p.R463C; 17:81695993-81695993	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1552C>T; p.R518W; 17:81696515-81696515	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.919C>T; p.L307L; 17:81693948-81693948	pancreas	carcinoma	Substitution - coding silent
c.13A>G; p.S5G; 17:81684079-81684079	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1552C>T; p.R518W; 17:81696515-81696515	oesophagus	carcinoma	Substitution - Missense
c.945G>A; p.S315S; 17:81694823-81694823	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.542A>G; p.H181R; 17:81691451-81691451	skin	malignant_melanoma	Substitution - Missense
c.841-1G>T; p.?; 17:81693869-81693869	urinary_tract; bladder	carcinoma	Unknown
c.902C>T; p.A301V; 17:81693931-81693931	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.222C>T; p.N74N; 17:81687026-81687026	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2019C>T; p.N673N; 17:81700697-81700697	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.822G>A; p.A274A; 17:81693734-81693734	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1398C>T; p.Y466Y; 17:81696361-81696361	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.508A>T; p.R170W; 17:81690713-81690713	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1204G>A; p.E402K; 17:81695810-81695810	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.291G>T; p.K97N; 17:81687095-81687095	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.863C>T; p.S288L; 17:81693892-81693892	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1850G>T; p.G617V; 17:81696966-81696966	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2199G>A; p.A733A; 17:81701107-81701107	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1348C>T; p.H450Y; 17:81695954-81695954	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.554G>A; p.C185Y; 17:81691463-81691463	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]