| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5335 |
Name | PLCG1 |
Synonymous | phospholipase C, gamma 1;PLCG1;phospholipase C, gamma 1 |
Definition | 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate|1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1|PLC-148|PL |
Position | 20q12-q13.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | PLCgamma1(h) + Synapsin-1(r) <==> PLCgamma1(h):Synapsin-1(r) (binding) | EpoR(m){pY401} + PLCgamma1(h) <==> EpoR(m){pY401}:PLCgamma1(h) (binding) | ErbB2(r){pY1227} + PLCgamma1(h) <==> ErbB2(r){pY1227}:PLCgamma1(h) (binding) | PLCgamma1(h) + ATP --EGFR(h)--> PLCgamma1(h){p} + ADP (phosphorylation) | PLCgamma1(h) + Vdp(h) <==> PLCgamma1(h):Vdp(h) (binding) | PLCgamma1(h) + ATP --Lck(m.s.)--> PLCgamma1(h){pY} + ADP (phosphorylation) | PLCgamma1(h) + ATP --ZAP-70(m.s.){pY319}--> PLCgamma1(h){pY} + ADP (phosphorylation) | PLCgamma1(h) + Src(h) + G-gamma(h):G-beta(h) <==> PLCgamma1(h):Src(h):G-gamma(h):G-beta(h) (binding) | IRS-2(h) + PLCgamma1(h) <==> IRS-2(h):PLCgamma1(h) (binding) | PLCgamma1(h) + ATP --> PLCgamma1(h){pY} + ADP (phosphorylation) | PLCgamma1(h) + RhoA(h):GTP <==> PLCgamma1(h):RhoA(h):GTP (binding) | PLCgamma1(h) + RhoA(m.s.):GTP <==> PLCgamma1(h):RhoA(m.s.):GTP (binding) | PLCgamma1(h) --> PLCgamma1(h) (translocation) | actin(h) + PLCgamma1(h) + gelsolin(h) <==> actin(h):PLCgamma1(h):gelsolin(h) (binding) | PLCgamma1(h) + SLP-76(m.s.) <==> PLCgamma1(h):SLP-76(m.s.) (binding) | Syk(h){pY} + CD22(h){pY} + SHP-1(h) + PLCgamma1(h) <==> Syk(h){pY}:CD22(h){pY}:SHP-1(h):PLCgamma1(h) (binding) | ErbB2(h){pY} + PLCgamma1(h) <==> ErbB2(h){pY}:PLCgamma1(h) (binding) | PLCgamma1(h) --> LAT(h) (binding) | PLCgamma1(h) --> Shb(h) (binding) | PLCgamma1(h) + ATP --> PLCgamma1(h){pY783} + ADP (phosphorylation) | ErbB3(r){pY} + PLCgamma1(h) <==> ErbB3(r){pY}:PLCgamma1(h) (binding) | PLCgamma1(h) + ATP --> PLCgamma1(h){p} + ADP (phosphorylation) | PLCgamma1(h) + Plexin-B1-isoform1(h) <==> PLCgamma1(h):Plexin-B1-isoform1(h) (binding) | PLCgamma1(h) + Plexin-B1(h) <==> PLCgamma1(h):Plexin-B1(h) (binding) | plexin-B2(h) + PLCgamma1(h) <==> plexin-B2(h):PLCgamma1(h) (binding) | PLCgamma1(h) + Grb-2(h) + LAT(h){pY} <==> PLCgamma1(h):Grb-2(h):LAT(h){pY} (binding) | PLCgamma1(h) + LAT-Short(h){pY} <==> PLCgamma1(h):LAT-Short(h){pY} (binding) | ltk(h) + PLCgamma1(h) + Lck(h) + SLP-76(h){pY} <==> ltk(h):PLCgamma1(h):Lck(h):SLP-76(h){pY} (binding) | PLCgamma1(h) + 2 ATP --> PLCgamma1(h){pY775}{pY783} + 2 ADP (phosphorylation) | TLR2(m.s.) + PLCgamma1(h) <==> TLR2(m.s.):PLCgamma1(h) (binding) | PLCgamma1(h) + LAT-Short(h){pY132} <==> PLCgamma1(h):LAT-Short(h){pY132} (binding) | PLCgamma1(h) + Vav(h){pY142}{pY160}{pY174} <==> PLCgamma1(h):Vav(h){pY142}{pY160}{pY174} (binding) | PLCgamma1(h){p} --CD148(h)--> PLCgamma1(h) + p (dephosphorylation) | PLCG1(h) --> PLCgamma1(h) (expression). | PLCgamma1(h) --> PLCgamma1(h) (translocation) | actin(h):PLCgamma1(h):gelsolin(h) <==> actin(h) + gelsolin(h) + PLCgamma1(h) (dissociation) | CD22(h){pY} --> PLCgamma1(h) (binding) | SHP-1(h) --> PLCgamma1(h) (binding) | Syk(h) --> PLCgamma1(h) (binding) | ZAP-70(h) --> PLCgamma1(h) (binding) | SLP-76(h) --> PLCgamma1(h) (binding) | SKAP55(m.s.) --> PLCgamma1(h) (increase of phosphorylation) | HR(h) --/ PLCgamma1(h) (decrease of abundance) | PIP2 --PLCgamma1(h)--> IP3 + DAG (hydrolysis) | ErbB1-p170(h){pY} + PLCgamma1(h) <==> PLCgamma1(h):ErbB1-p170(h){pY} (binding) | PLCgamma1(h) + ErbB2(h){pY} <==> PLCgamma1(h):ErbB2(h){pY} (binding) | ErbB1-p170(h){pY1016} + PLCgamma1(h) <==> ErbB1-p170(h){pY1016}:PLCgamma1(h) (binding) | ErbB2(h){pY1023}{pY1139}{pY1221}{pY1222} + PLCgamma1(h) <==> ErbB2(h){pY1023}{pY1139}{pY1221}{pY1222}:PLCgamma1(h) (binding) | ErbB3-isoform1(h){pY1276}{pY1289} + PLCgamma1(h) <==> ErbB3-isoform1(h){pY1276}{pY1289}:PLCgamma1(h) (binding) | ErbB4(h){pY1162}{pY1258}{pY1284} + PLCgamma1(h) <==> ErbB4(h){pY1162}{pY1258}{pY1284}:PLCgamma1(h) (binding) | PLCgamma1(h) + EGFR(ca) <==> PLCgamma1(h):EGFR(ca) (binding) | dynamin(ca) + PLCgamma1(h) <==> dynamin(ca):PLCgamma1(h) (binding) | PLCgamma1(h) + Sos(ca) <==> PLCgamma1(h):Sos(ca) (binding) | PLCgamma1(h) + ATP --trkA(h){pY}--> PLCgamma1(h){p} + ADP (phosphorylation) | PLCG1(h) --> PLCgamma1(h) (expression). |
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Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 771 | Phosphotyrosine. | Swiss-Prot 53.0 | 775 | Phosphotyrosine. | Swiss-Prot 53.0 | 783 | Phosphotyrosine. | Swiss-Prot 53.0 | 1253 | Phosphotyrosine. | Swiss-Prot 53.0 | 771 | Phosphotyrosine (Syk;TRKB;Sky) | 1689310;1708307;8657103;12601080;15144186;15592455 | Phospho.ELM 6.0 | 472 | Phosphotyrosine (EGFR;FGFR1) | 1689310;7991458;12601080 | Phospho.ELM 6.0 | 783 | Phosphotyrosine (Syk;TRKB;EGF) | 1689310;1708307;8657103;12601080;16126727;16038803 | Phospho.ELM 6.0 | 1253 | Phosphotyrosine (TRKB;EGFR;FG) | 1689310;1708307;12601080;15144186;17081983 | Phospho.ELM 6.0 | 1253 | Phosphotyrosine (PDGFR beta;E) | 96108162;1689310;1708307 | Phospho.ELM 6.0 | 775 | Phosphotyrosine | 15592455 | Phospho.ELM 6.0 | 1248 | Phosphoserine (PKC alpha;PK) | 1370476 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr20 |
Promoter: 39198075 - 39200075 | Agilent_014791 |
chr20 |
Promoter: 39198075 - 39200075 | GSE27584 |
chr20 |
Promoter: 39198075 - 39200075 | GSE27584 |
chr20 |
Promoter: 39198075 - 39200075 | Agilent_014791_44K |