| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5335 |
Name | PLCG1 |
Synonym | NCKAP3|PLC-II|PLC1|PLC148|PLCgamma1;phospholipase C, gamma 1;PLCG1;phospholipase C, gamma 1 |
Definition | 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate|1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1|PLC-148|PL |
Position | 20q12-q13.1 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | pertussis toxin-insensitive ccr5 signaling in macrophage;PID BioCarta;100214 |
Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | Axon guidance mediated by netrin;PANTHER;P00009 |
Pathway | Phosphatidylinositol signaling system;KEGG PATHWAY;hsa04070 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | phospholipase c signaling pathway;PID BioCarta;100069 |
Pathway | VEGFR1 specific signals;PID Curated;200151 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | N-cadherin signaling events;PID Curated;200180 |
Pathway | Signaling by EGFR;Reactome;REACT:9417 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | egf signaling pathway;PID BioCarta;100181 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | D-myo-inositol-5-phosphate metabolism;BioCyc;PWY-6367 |
Pathway | Histamine H1 receptor mediated signaling pathway;PANTHER;P04385 |
Pathway | Inositol phosphate metabolism;KEGG PATHWAY;hsa00562 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | bcr signaling pathway;PID BioCarta;100227 |
Pathway | EPHA forward signaling;PID Curated;200121 |
Pathway | S1P4 pathway;PID Curated;200043 |
Pathway | tpo signaling pathway;PID BioCarta;100012 |
Pathway | trka receptor signaling pathway;PID BioCarta;100011 |
Pathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy;PID BioCarta;100221 |
Pathway | Nephrin/Neph1 signaling in the kidney podocyte;PID Curated;200132 |
Pathway | signaling pathway from g-protein families;PID BioCarta;100153 |
Pathway | effects of calcineurin in keratinocyte differentiation;PID BioCarta;100222 |
Pathway | 5HT2 type receptor mediated signaling pathway;PANTHER;P04374 |
Pathway | Generation of second messenger molecules;PID Reactome;500481 |
Pathway | EGFR interacts with phospholipase C-gamma;PID Reactome;500511 |
Pathway | Signaling by PDGF;Reactome;REACT:16888 |
Pathway | PLC-gamma1 signalling;PID Reactome;500632 |
Pathway | growth hormone signaling pathway;PID BioCarta;100155 |
Pathway | epo signaling pathway;PID BioCarta;100175 |
Pathway | D-myo-inositol (1,4,5)-trisphosphate biosynthesis;BioCyc;PWY-6351 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | Epithelial cell signaling in Helicobacter pylori infection;KEGG PATHWAY;hsa05120 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | Oxytocin receptor mediated signaling pathway;PANTHER;P04391 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | Vibrio cholerae infection;KEGG PATHWAY;hsa05110 |
Pathway | E-cadherin signaling in keratinocytes;PID Curated;200125 |
Pathway | Class I PI3K signaling events;PID Curated;200098 |
Pathway | Trk receptor signaling mediated by PI3K and PLC-gamma;PID Curated;200183 |
Pathway | Regulation of CDC42 activity;PID Curated;200059 |
Pathway | S1P1 pathway;PID Curated;200071 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Role of second messengers in netrin-1 signaling;PID Reactome;500091 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | bioactive peptide induced signaling pathway;PID BioCarta;100226 |
Pathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling;PID BioCarta;100236 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | actions of nitric oxide in the heart;PID BioCarta;100094 |
Pathway | cxcr4 signaling pathway;PID BioCarta;100192 |
Pathway | nerve growth factor pathway (ngf);PID BioCarta;100096 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia;PID BioCarta;100184 |
Pathway | phospholipases;BioCyc;LIPASYN-PWY |
Pathway | Down-stream signal transduction;PID Reactome;500509 |
Pathway | vegf hypoxia and angiogenesis;PID BioCarta;100006 |
Pathway | pdgf signaling pathway;PID BioCarta;100077 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | role of mef2d in t-cell apoptosis;PID BioCarta;100109 |
Pathway | Thyrotropin-releasing hormone receptor signaling pathway;PANTHER;P04394 |
Pathway | PDGFR-alpha signaling pathway;PID Curated;200140 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | LPA receptor mediated events;PID Curated;200011 |
Pathway | VEGF signaling pathway;KEGG PATHWAY;hsa04370 |
Pathway | PECAM1 interactions;PID Reactome;500307 |
Pathway | EPO signaling pathway;PID Curated;200157 |
Pathway | Phospholipase C-mediated cascade;PID Reactome;500249 |
Pathway | EGF receptor (ErbB1) signaling pathway;PID Curated;200085 |
Pathway | Neurotrophic factor-mediated Trk receptor signaling;PID Curated;200128 |
Pathway | ionomycin and phorbal ester signaling pathway;PID BioCarta;100121 |
Pathway | Leukocyte transendothelial migration;KEGG PATHWAY;hsa04670 |
Pathway | role of erk5 in neuronal survival pathway;PID BioCarta;100171 |
Pathway | Signaling events mediated by focal adhesion kinase;PID Curated;200192 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | VEGF signaling pathway;PANTHER;P00056 |
Pathway | phosphoinositides and their downstream targets;PID BioCarta;100059 |
Pathway | links between pyk2 and map kinases;PID BioCarta;100057 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | t cell receptor signaling pathway;PID BioCarta;100022 |
Pathway | fc epsilon receptor i signaling in mast cells;PID BioCarta;100165 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | Signaling by FGFR;Reactome;REACT:9470 |
Pathway | FGF signaling pathway;PID Curated;200189 |
Pathway | Netrin-mediated signaling;PID Curated;200074 |
Disease | Turner's syndrome;FunDO |
Disease | bipolar disorder;GAD |
Disease | Colon cancer;FunDO |
Disease | PSYCH;GAD |
Disease | Prostate cancer;FunDO |
External Links | |
Links to Entrez Gene | 5335 |
Links to all GeneRIF Items | 5335 |
Links to iHOP | 5335 |
Sequence Information | |
Nucleotide Sequence | >5335 : length: 5328 AGGAGCCGCCGCCGGGTCCCGCTCGTCTGCCGCCTCAGCCTCAGCCCCAACCTCAGCCGC CGCCGTTGCGCTTGCTCCCGGGCGGTCCTGGCCTGTGCCGCCGCCGCCCCCAGCGTCGGA GCCATGGCGGGCGCCGCGTCCCCTTGCGCCAACGGCTGCGGGCCCGGCGCGCCCTCGGAC GCCGAGGTGCTGCACCTCTGCCGCAGCCTCGAGGTGGGCACCGTCATGACTTTGTTCTAC TCCAAGAAGTCGCAGCGACCCGAGCGGAAGACCTTCCAGGTCAAGCTGGAGACGCGCCAG ATCACGTGGAGCCGGGGCGCCGACAAGATCGAGGGGGCCATTGACATTCGTGAAATTAAG GAGATCCGCCCAGGGAAGACCTCACGGGACTTTGATCGCTATCAAGAGGACCCAGCTTTC CGGCCGGACCAGTCACATTGCTTTGTCATTCTCTATGGAATGGAATTTCGCCTGAAAACG CTGAGCCTGCAAGCCACATCTGAGGATGAAGTGAACATGTGGATCAAGGGCTTAACTTGG CTGATGGAGGATACATTGCAGGCACCCACACCCCTGCAGATTGAGAGGTGGCTCCGGAAG CAGTTTTACTCAGTGGATCGGAATCGTGAGGATCGTATATCAGCCAAGGACCTGAAGAAC ATGCTGTCCCAGGTCAACTACCGGGTCCCCAACATGCGCTTCCTCCGAGAGCGGCTGACG GACCTGGAGCAGCGCAGCGGGGACATCACCTACGGGCAGTTTGCTCAGCTGTACCGCAGC CTCATGTACAGCGCCCAGAAGACGATGGACCTCCCCTTCTTGGAAGCCAGTACTCTGAGG GCTGGGGAGCGGCCGGAGCTTTGCCGAGTGTCCCTTCCTGAGTTCCAGCAGTTCCTTCTT GACTACCAGGGGGAGCTGTGGGCTGTTGATCGCCTCCAGGTGCAGGAGTTCATGCTCAGC TTCCTCCGAGACCCCTTACGAGAGATCGAGGAGCCATACTTCTTCCTGGATGAGTTTGTC ACCTTCCTGTTCTCCAAAGAGAACAGTGTGTGGAACTCGCAGCTGGATGCAGTATGCCCG GACACCATGAACAACCCTCTTTCCCACTACTGGATCTCCTCCTCGCACAACACGTACCTG ACCGGGGACCAGTTCTCCAGTGAGTCCTCCTTGGAAGCCTATGCTCGCTGCCTGCGGATG GGCTGTCGCTGCATTGAGTTGGACTGCTGGGACGGCCCGGATGGGATGCCAGTTATTTAC CATGGGCACACCCTTACCACCAAGATCAAGTTCTCAGATGTCCTGCACACCATCAAGGAG CATGCCTTTGTGGCCTCAGAGTACCCAGTCATCCTGTCCATTGAGGACCACTGCAGCATT GCCCAGCAGAGAAACATGGCCCAATACTTCAAGAAGGTGCTGGGGGACACACTCCTCACC AAGCCCGTGGAGATCTCTGCCGACGGGCTCCCCTCACCCAACCAGCTTAAGAGGAAGATC CTCATCAAGCACAAGAAGCTGGCTGAGGGCAGTGCCTACGAGGAGGTGCCTACATCCATG ATGTACTCTGAGAACGACATCAGCAACTCTATCAAGAATGGCATCCTCTACCTGGAGGAC CCTGTGAACCACGAATGGTATCCCCACTACTTTGTTCTGACCAGCAGCAAGATCTACTAC TCTGAGGAGACCAGCAGTGACCAGGGCAACGAGGATGAGGAGGAGCCCAAGGAGGTCAGC AGCAGCACAGAGCTGCACTCCAATGAGAAGTGGTTCCATGGGAAGCTAGGGGCAGGGCGT GACGGGCGTCACATCGCTGAGCGCCTGCTTACTGAGTACTGCATCGAGACCGGAGCCCCT GACGGCTCCTTCCTCGTGCGAGAGAGTGAGACCTTCGTGGGCGACTACACGCTCTCTTTC TGGCGGAACGGGAAAGTCCAGCACTGCCGTATCCACTCCCGGCAAGATGCTGGGACCCCC AAGTTCTTCTTGACAGACAACCTCGTCTTTGACTCCCTCTATGACCTCATCACGCACTAC CAGCAGGTGCCCCTGCGCTGTAATGAGTTTGAGATGCGACTTTCAGAGCCTGTCCCACAG ACCAACGCCCACGAGAGCAAAGAGTGGTACCACGCGAGCCTGACCAGAGCACAGGCTGAG CACATGCTAATGCGCGTCCCTCGTGATGGGGCCTTCCTGGTGCGGAAGCGGAATGAACCC AACTCATATGCCATCTCTTTCCGGGCTGAGGGCAAGATCAAGCATTGCCGTGTCCAGCAA GAGGGCCAGACAGTGATGCTAGGGAACTCGGAGTTCGACAGCCTTGTTGACCTCATCAGC TACTATGAGAAACACCCGCTATACCGCAAGATGAAGCTGCGCTATCCCATCAACGAGGAG GCACTGGAGAAGATTGGCACAGCTGAGCCTGACTACGGGGCCCTGTATGAGGGACGCAAC CCTGGCTTCTATGTAGAGGCAAACCCTATGCCAACTTTCAAGTGTGCAGTCAAAGCCCTC TTTGACTACAAGGCCCAGAGGGAGGACGAGCTGACCTTCATCAAGAGCGCCATCATCCAG AATGTGGAGAAGCAAGAGGGAGGCTGGTGGCGAGGGGACTACGGAGGGAAGAAGCAGCTG TGGTTCCCATCAAACTACGTGGAAGAGATGGTCAACCCCGTGGCCCTGGAGCCGGAGAGG GAGCACTTGGACGAGAACAGCCCCCTAGGGGACTTGCTGCGGGGGGTCTTGGATGTGCCG GCTTGTCAGATTGCCATCCGTCCTGAGGGCAAGAACAACCGGCTCTTCGTCTTCTCCATC AGCATGGCGTCGGTGGCCCACTGGTCCCTGGATGTTGCTGCCGACTCACAGGAGGAGCTG CAGGACTGGGTGAAAAAGATCCGTGAAGTGGCCCAGACAGCAGACGCCAGGCTCACTGAA GGGAAGATAATGGAACGGAGGAAGAAGATTGCCCTGGAGCTCTCTGAACTTGTCGTCTAC TGCCGGCCTGTTCCCTTTGATGAAGAGAAGATTGGCACAGAACGTGCTTGCTACCGGGAC ATGTCATCCTTCCCGGAAACCAAGGCTGAGAAATACGTGAACAAGGCCAAAGGCAAGAAG TTCCTTCAGTACAATCGACTGCAGCTCTCCCGCATCTACCCCAAGGGCCAGCGACTGGAT TCCTCCAACTACGATCCTTTGCCCATGTGGATCTGTGGCAGTCAGCTTGTGGCCCTCAAC TTCCAGACCCCTGACAAGCCTATGCAGATGAACCAGGCCCTCTTCATGACGGGCAGGCAC TGTGGCTACGTGCTGCAGCCAAGCACCATGCGGGATGAGGCCTTCGACCCCTTTGACAAG AGCAGCCTCCGCGGGCTGGAGCCATGTGCCATCTCTATTGAGGTGCTGGGGGCCCGACAT CTGCCAAAGAATGGCCGAGGCATTGTGTGTCCTTTTGTGGAGATTGAGGTGGCTGGAGCT GAGTATGACAGCACCAAGCAGAAGACAGAGTTTGTGGGTCAGTCTGTCTTCCCAGTCATC CTCCTCATCCTGCTGGGGCACTGCAAGCCTCTCCCCACCAGTCATCCCATCCTCTCCCAC GGTGACCTGAAGCCTTTTGTCGTTGCCTTCACAGTGGACAATGGACTCAACCCTGTATGG CCAGCCAAGCCCTTCCACTTCCAGATCAGTAACCCTGAATTTGCCTTTCTGCGCTTCGTG GTGTATGAGGAAGACATGTTTAGTGACCAGAATTTCCTGGCTCAGGCTACTTTCCCAGTA AAAGGCCTGAAGACAGGATACAGAGCAGTGCCTTTGAAGAACAACTACAGTGAGGACCTG GAGTTGGCCTCCCTGCTGATCAAGATTGACATTTTCCCTGCCAAGCAGGAGAATGGTGAC CTCAGTCCCTTCAGTGGTACGTCCCTGCGGGAGCGGGGCTCAGATGCCTCAGGCCAGCTG TTTCATGGCCGAGCCCGGGAAGGCTCCTTTGAATCCCGCTACCAGCAGCCGTTTGAGGAC TTCCGCATCTCCCAGGAGCATCTCGCAGACCATTTTGACAGTCGAGAACGAAGGGCCCCA AGAAGGACTCGGGTCAATGGAGACAACCGCCTCTAGTTGTACCCCAGCCTCGTTGGAGAG CAGCAGGTGCTGTGCGCCTTGTAGAATGCCGCGAACTGGGTTCTTTGGAAGCAGCCCCCT GTGGCGGCCTTCCGGGTCTCGCAGCCTGAAGCCTGGATTCCAGCAGTGAATGCTAGACAG AAACCAAGCCATTAATGAGATGTTATTACTGTTTTGGGCCTCCATGCCCCAGCTCTGGAT GAAGGCAAAAACTGTACTGTGTTTCGCATTAAGCACACACATCTGGCCCTGACTTCTGGA GATGGATCCTTCCATCTTGTGGGGCCAGGACCATGGCCGAAGCCCCTTGGAGAGAGAGGC TGCCTCAGCCAGTGGCACAGGAGACTCCAAGGAGCTACTGACATTCCTAAGAGTGGAGGA GGAGGAGGAGCCTTGCTGGGCCAGGGAAACAAAGTTTACATTGTCCTGTAGCTTTAAAAC CACAGCTGGGCAGGGTGAGAAGCTAGATGCCCCTGCAGTTTGGCCCTGGAGCCAGGGCAG AGGAATGTAGGGCCTGCATGGAGAAGGGTTCTGCCCTGCCTGAGGAGGAGGACACAGCAC AAGGGCACATTGCCCATGGCTGGGAACATGACCCAGCCTGAAAGATACAGGGGATCATGT TAAAAATAGCAGTATTATTTTTCGTCTCAATGGTATTGTAACTAAGTTATTTACTCCTCC TGCTCCTCACCCCTGTAGGGAAACCTTGGAGAGGAGAGTGGCAGGTGGGCTGCCTGCTGT GTTAAGAGGACTTAGTTTGTGATGTAAGGCACTGTCAGGAATGGGGGGCGGGCCAGGGTG GGAAGAGAAGAAATAGCAGAGCCTATTTTGGTGAGGTTTTTTGTTTTTAAGTCAAAGAAG ACTCAGTATGCTTTCCCTGAGGAATGAAAAAGGGATTGAGGAGTTGCCTGACTCCTGGGT GGGTGGGGTACAGGCAGTTAGGTGCTGAATGAAGCTGCCATCCTTGCTGCAGCTTCTAAC TGGTAAAAAGATCCAGGGATGGAGATGGGAAGGTTAGAAAGGCAGCCCTCACCTCTGAGG ACAGAGGCCGGGGTCCAGGCCCGTGGGCGCAAAGGTGCCTCATAGCATAGCCAGCATTCA GCACACACAAACCTACTGCCCACATTTGGGCTCAGGGTTGGCCATTTGCTAGTTCTGCTG CCCTCTTAAGATCTGACTGCCAAATAAATCATCCTCATGTCCTTTTTC |
Protein Sequence | >5335 : length: 1330 MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA QQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP GFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLW FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS SLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVGQSVFPVIL LILLGHCKPLPTSHPILSHGDLKPFVVAFTVDNGLNPVWPAKPFHFQISNPEFAFLRFVV YEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKQENGDL SPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRISQEHLADHFDSRERRAPR RTRVNGDNRL |