| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5335 |
Name | PLCG1 |
Synonymous | phospholipase C, gamma 1;PLCG1;phospholipase C, gamma 1 |
Definition | 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate|1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1|PLC-148|PL |
Position | 20q12-q13.1 |
Gene Type | protein-coding |
Gene Interactions: | Physical Interaction Metabolic Interaction Signaling Interaction |
Physical Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
in same component |
ARHGEF7 | NCI_NATURE; |
in same component |
EGF | NCI_NATURE; |
in same component |
EGF | REACTOME; |
in same component |
EGFR | NCI_NATURE; |
in same component |
EGFR | REACTOME; |
in same component |
GIT1 | NCI_NATURE; |
in same component |
GRAP2 | NCI_NATURE; |
in same component |
GRAP2 | REACTOME; |
in same component |
GRIN2A | IMID; |
in same component |
ITK | NCI_NATURE; |
in same component |
KHDRBS2 | IMID; |
in same component |
KIRREL | NCI_NATURE; |
in same component |
LAT2 | NCI_NATURE; |
in same component |
LAT | NCI_NATURE; |
in same component |
LAT | REACTOME; |
in same component |
LCP2 | NCI_NATURE; |
in same component |
LCP2 | REACTOME; |
in same component |
NGF | NCI_NATURE; |
in same component |
NGF | REACTOME; |
in same component |
NPHS1 | NCI_NATURE; |
in same component |
NPHS2 | NCI_NATURE; |
in same component |
PDGFB | NCI_NATURE; |
in same component |
PDGFRB | NCI_NATURE; |
in same component |
PECAM1 | REACTOME; |
in same component |
SYN1 | IMID; |
in same component |
TRPV1 | NCI_NATURE; |
in same component |
VAV1 | NCI_NATURE; |
interacts with |
ABI1 | MINT; |
interacts with |
ABL1 | BIOGRID; |
interacts with |
ABL1 | MINT; |
interacts with |
ABL2 | MINT; |
interacts with |
ADNP | MINT; |
interacts with |
AFF2 | MINT; |
interacts with |
AGTR1 | MINT; |
interacts with |
AIRE | MINT; |
interacts with |
AKAP2 | MINT; |
interacts with |
AKT1 | MINT; |
interacts with |
ALK | BIOGRID; |
interacts with |
ARHGAP32 | BIOGRID; |
interacts with |
ARHGEF11 | MINT; |
interacts with |
ARHGEF2 | BIOGRID; |
interacts with |
ASAP1 | MINT; |
interacts with |
ASAP2 | MINT; |
interacts with |
AXL | MINT; |
interacts with |
BAG3 | BIOGRID; |
interacts with |
CAMK2A | BIOGRID; |
interacts with |
CAST | MINT; |
interacts with |
CBL | BIOGRID; |
interacts with |
CD22 | BIOGRID; |
interacts with |
CHAF1A | MINT; |
interacts with |
CKAP5 | MINT; |
interacts with |
COBRA1 | MINT; |
interacts with |
CSMD2 | MINT; |
interacts with |
DDIT4 | MINT; |
interacts with |
DGKZ | BIOGRID; |
interacts with |
DLGAP1 | MINT; |
interacts with |
DLGAP3 | MINT; |
interacts with |
DLX4 | MINT; |
interacts with |
DOK1 | BIOGRID; |
interacts with |
DOK1 | CELL_MAP; |
interacts with |
DTNBP1 | MINT; |
interacts with |
DUSP15 | MINT; |
interacts with |
EEF1A1 | BIOGRID; |
interacts with |
EFS | MINT; |
interacts with |
EGFR | BIOGRID; |
interacts with |
EGFR | MINT; |
interacts with |
EPHB2 | BIOGRID; |
interacts with |
EPOR | BIOGRID; |
interacts with |
EPX | MINT; |
interacts with |
ERBB2 | BIOGRID; |
interacts with |
ERBB2 | MINT; |
interacts with |
ERBB3 | MINT; |
interacts with |
EXTL3 | MINT; |
interacts with |
F2RL2 | MINT; |
interacts with |
FANCA | MINT; |
interacts with |
FCGR2B | MINT; |
interacts with |
FCGR2C | MINT; |
interacts with |
FGFR1 | BIOGRID; |
interacts with |
FGFR1 | MINT; |
interacts with |
FLNA | MINT; |
interacts with |
FLNB | MINT; |
interacts with |
FLNC | MINT; |
interacts with |
FLT1 | BIOGRID; |
interacts with |
GAB1 | BIOGRID; |
interacts with |
GAB2 | BIOGRID; |
interacts with |
GHR | BIOGRID; |
interacts with |
GHR | MINT; |
interacts with |
GIT1 | BIOGRID; |
interacts with |
GLTSCR1 | MINT; |
interacts with |
GSN | BIOGRID; |
interacts with |
ID4 | MINT; |
interacts with |
IL3RA | MINT; |
interacts with |
IRS2 | BIOGRID; |
interacts with |
ISG20L2 | MINT; |
interacts with |
ITK | BIOGRID; |
interacts with |
JAK2 | MINT; |
interacts with |
KDR | BIOGRID; |
interacts with |
KDR | MINT; |
interacts with |
KHDRBS1 | BIOGRID; |
interacts with |
KHDRBS1 | CELL_MAP; |
interacts with |
KIT | BIOGRID; |
interacts with |
KIT | CELL_MAP; |
interacts with |
KIT | MINT; |
interacts with |
LAT2 | BIOGRID; |
interacts with |
LAT | BIOGRID; |
interacts with |
LAT | MINT; |
interacts with |
LCP2 | BIOGRID; |
interacts with |
LCP2 | MINT; |
interacts with |
LIG3 | MINT; |
interacts with |
LTK | BIOGRID; |
interacts with |
MAP4K1 | MINT; |
interacts with |
MAP4 | MINT; |
interacts with |
MEPE | MINT; |
interacts with |
MST1R | BIOGRID; |
interacts with |
NTRK2 | BIOGRID; |
interacts with |
NTRK3 | BIOGRID; |
interacts with |
PAK1 | BIOGRID; |
interacts with |
PARK2 | BIOGRID; |
interacts with |
PDGFA | BIOGRID; |
interacts with |
PDGFRA | BIOGRID; |
interacts with |
PDGFRA | MINT; |
interacts with |
PDGFRB | BIOGRID; |
interacts with |
PDGFRB | MINT; |
interacts with |
PDIA2 | MINT; |
interacts with |
PECAM1 | BIOGRID; |
interacts with |
PHACTR2 | MINT; |
interacts with |
PICALM | BIOGRID; |
interacts with |
PKN2 | BIOGRID; |
interacts with |
PLD1 | MINT; |
interacts with |
PLD2 | BIOGRID; |
interacts with |
PLXNB1 | BIOGRID; |
interacts with |
PLXNB2 | BIOGRID; |
interacts with |
PPFIA4 | MINT; |
interacts with |
PRKD1 | BIOGRID; |
interacts with |
PTK2 | BIOGRID; |
interacts with |
PTPRJ | BIOGRID; |
interacts with |
RAC1 | MINT; |
interacts with |
RAG1 | MINT; |
interacts with |
RASA1 | BIOGRID; |
interacts with |
RGS7 | MINT; |
interacts with |
RHOA | BIOGRID; |
interacts with |
RIN3 | MINT; |
interacts with |
RPL13 | MINT; |
interacts with |
RRAS | MINT; |
interacts with |
RYR1 | MINT; |
interacts with |
SCARB2 | MINT; |
interacts with |
SEC24B | MINT; |
interacts with |
SELE | BIOGRID; |
interacts with |
SERPINC1 | MINT; |
interacts with |
SH2B3 | BIOGRID; |
interacts with |
SH3BP2 | BIOGRID; |
interacts with |
SH3BP2 | MINT; |
interacts with |
SHANK2 | MINT; |
interacts with |
SHANK3 | MINT; |
interacts with |
SHB | BIOGRID; |
interacts with |
SHC1 | BIOGRID; |
interacts with |
SLC23A1 | MINT; |
interacts with |
SNX17 | MINT; |
interacts with |
SNX7 | MINT; |
interacts with |
SOS1 | BIOGRID; |
interacts with |
SOS1 | MINT; |
interacts with |
SOS2 | BIOGRID; |
interacts with |
SOS2 | MINT; |
interacts with |
SPEN | MINT; |
interacts with |
SRC | BIOGRID; |
interacts with |
SUV39H2 | MINT; |
interacts with |
SYK | BIOGRID; |
interacts with |
SYK | MINT; |
interacts with |
SYNCRIP | BIOGRID; |
interacts with |
TDRD1 | MINT; |
interacts with |
TGOLN2 | MINT; |
interacts with |
TNK1 | BIOGRID; |
interacts with |
TRAIP | MINT; |
interacts with |
TRPM7 | BIOGRID; |
interacts with |
TUB | BIOGRID; |
interacts with |
VAV1 | BIOGRID; |
interacts with |
VAV1 | MINT; |
interacts with |
VIL1 | INTACT; |
interacts with |
WAS | BIOGRID; |
interacts with |
ZAP70 | BIOGRID; |
interacts with |
ZP2 | MINT; |
Metabolic Interaction [Top] | ||
There is no record for PLCG1 | ||
Signaling Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
reacts with |
CBL | NCI_NATURE; |
reacts with |
DCC | REACTOME; |
reacts with |
EGF | NCI_NATURE; |
reacts with |
EGF | REACTOME; |
reacts with |
EGFR | NCI_NATURE; |
reacts with |
EGFR | REACTOME; |
reacts with |
GRAP2 | NCI_NATURE; |
reacts with |
GRAP2 | REACTOME; |
reacts with |
GRIN2A | IMID; |
reacts with |
ITK | NCI_NATURE; |
reacts with |
KHDRBS2 | IMID; |
reacts with |
KIRREL | NCI_NATURE; |
reacts with |
LAT2 | NCI_NATURE; |
reacts with |
LAT | NCI_NATURE; |
reacts with |
LAT | REACTOME; |
reacts with |
LCP2 | NCI_NATURE; |
reacts with |
LCP2 | REACTOME; |
reacts with |
NGF | NCI_NATURE; |
reacts with |
NGF | REACTOME; |
reacts with |
NPHS1 | NCI_NATURE; |
reacts with |
NPHS2 | NCI_NATURE; |
reacts with |
NTN1 | REACTOME; |
reacts with |
PDGFB | NCI_NATURE; |
reacts with |
PDGFRB | NCI_NATURE; |
reacts with |
PECAM1 | REACTOME; |
reacts with |
PITPNA | REACTOME; |
reacts with |
PLCG1 | IMID; |
reacts with |
PLCG1 | NCI_NATURE; |
reacts with |
PLCG1 | REACTOME; |
reacts with |
SYN1 | IMID; |
reacts with |
TRPV1 | NCI_NATURE; |
reacts with |
VAV1 | NCI_NATURE; |
state change |
ABL1 | NCI_NATURE; |
state change |
BTK | NCI_NATURE; |
state change |
CBL | NCI_NATURE; |
state change |
EGF | REACTOME; |
state change |
EGFR | IMID; |
state change |
EGFR | REACTOME; |
state change |
EPHA4 | NCI_NATURE; |
state change |
EPO | NCI_NATURE; |
state change |
EPOR | NCI_NATURE; |
state change |
FCER1A | NCI_NATURE; |
state change |
FCER1G | NCI_NATURE; |
state change |
FGFR1 | NCI_NATURE; |
state change |
FLT1 | NCI_NATURE; |
state change |
FRS2 | REACTOME; |
state change |
Fyn | CELL_MAP; |
state change |
FYN | IMID; |
state change |
GAB1 | NCI_NATURE; |
state change |
HCK | IMID; |
state change |
HGF | NCI_NATURE; |
state change |
IGHE | NCI_NATURE; |
state change |
JAK2 | NCI_NATURE; |
state change |
KDR | NCI_NATURE; |
state change |
LAT2 | NCI_NATURE; |
state change |
LCK | IMID; |
state change |
LCP2 | NCI_NATURE; |
state change |
LYN | IMID; |
state change |
LYN | NCI_NATURE; |
state change |
MET | NCI_NATURE; |
state change |
MS4A2 | NCI_NATURE; |
state change |
NGF | REACTOME; |
state change |
PDGFRA | NCI_NATURE; |
state change |
PDGFRB | IMID; |
state change |
PGF | NCI_NATURE; |
state change |
PLCG1 | NCI_NATURE; |
state change |
PLCG1 | REACTOME; |
state change |
PRKACA | IMID; |
state change |
S1PR1 | NCI_NATURE; |
state change |
S1PR4 | NCI_NATURE; |
state change |
SDC2 | NCI_NATURE; |
state change |
SRC | IMID; |
state change |
SYK | IMID; |
state change |
VAV1 | NCI_NATURE; |