| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4296 |
Name | MAP3K11 |
Synonymous | mitogen-activated protein kinase kinase kinase 11;MAP3K11;mitogen-activated protein kinase kinase kinase 11 |
Definition | SH3 domain-containing proline-rich kinase|mixed lineage kinase 3|protein-tyrosine kinase PTK1|src-homology 3 domain-containing proline-rich kinase |
Position | 11q13.1-q13.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | hippocalcin(h) + MLK3(h) <==> hippocalcin(h):MLK3(h) (binding) | 14-3-3epsilon(h) + MLK3(h) <==> 14-3-3epsilon(h):MLK3(h) (binding) | KIF3A(h) + MLK3(h) <==> KIF3A(h):MLK3(h) (binding) | PKARIIbeta(h) + MLK3(h) <==> PKARIIbeta(h):MLK3(h) (binding) | MLK3(h) + AKT-1(h){pT308}{pS473} <==> MLK3(h):AKT-1(h){pT308}{pS473} (binding) | Cdc42(h):GTP + MLK3(h) <==> Cdc42(h):GTP:MLK3(h) (binding) | GCK(h) + MLK3(h) <==> GCK(h):MLK3(h) (binding) | MLK3(h) + JIP-2(r) <==> MLK3(h):JIP-2(r) (binding) | Rac1(v.s.):GTP + MLK3(h) <==> Rac1(v.s.):GTP:MLK3(h) (binding) | MLK3(h) + POSH(m) <==> MLK3(h):POSH(m) (binding) | MLK3(h) + golgin-160(h) <==> MLK3(h):golgin-160(h) (binding) | MLK3(h) + GM130(h) <==> MLK3(h):GM130(h) (binding) | 2 MLK3(h) <==> (MLK3(h))2 (binding) | Hsp90(h) + MLK3(h) <==> Hsp90(h):MLK3(h) (binding) | Hsp50(h) + MLK3(h) <==> Hsp50(h):MLK3(h) (binding) | Hsp50(h) + MLK3(h) <==> Hsp50(h):MLK3(h) (binding) | MAP3K11(h) --> MLK3(h) (expression). | MKK4(m) + ATP --MLK3(h)--> MKK4(m){p} + ADP (phosphorylation) | MKK7(m) + ATP --MLK3(h)--> MKK7(m){p} + ADP (phosphorylation) | golgin-160(h) + NTP --MLK3(h)--> golgin-160(h){p} + NDP (phosphorylation) | golgin-160(h) + ATP --MLK3(h)--> golgin-160(h){p} + ADP (phosphorylation) | MKK7(m.s.) + ATP --MLK3(h)--> MKK7(m.s.){p} + ADP (phosphorylation) | MLK3(h) --> c-Jun(h){p} (increase of phosphorylation) | Hsp90-alpha(h) + MLK3(h) <==> Hsp90-alpha(h):MLK3(h) (binding) | HSP90BB(h) + MLK3(h) <==> HSP90BB(h):MLK3(h) (binding) | Hsp50(h) + MLK3(h) <==> Hsp50(h):MLK3(h) (binding) | MAP3K11(h) --> MLK3(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 277 | Phosphothreonine (by autocatalysis). | Swiss-Prot 53.0 | 281 | Phosphoserine (by autocatalysis andMAP4K1). | Swiss-Prot 53.0 | 507 | Phosphoserine. | Swiss-Prot 53.0 | 524 | Phosphoserine. | Swiss-Prot 53.0 | 555 | Phosphoserine. | Swiss-Prot 53.0 | 556 | Phosphoserine. | Swiss-Prot 53.0 | 654 | Phosphoserine. | Swiss-Prot 53.0 | 705 | Phosphoserine. | Swiss-Prot 53.0 | 724 | Phosphoserine. | Swiss-Prot 53.0 | 727 | Phosphoserine. | Swiss-Prot 53.0 | 740 | Phosphoserine. | Swiss-Prot 53.0 | 758 | Phosphoserine. | Swiss-Prot 53.0 | 770 | Phosphoserine. | Swiss-Prot 53.0 | 793 | Phosphoserine. | Swiss-Prot 53.0 | 277 | Phosphothreonine (MAP3K11) | 11053428 | Phospho.ELM 6.0 | 281 | Phosphoserine (MAP3K11;MAP4) | 11053428 | Phospho.ELM 6.0 | 524 | Phosphoserine | 11969422 | Phospho.ELM 6.0 | 705 | Phosphoserine | 11969422 | Phospho.ELM 6.0 | 724 | Phosphoserine | 11969422 | Phospho.ELM 6.0 | 758 | Phosphoserine | 11969422 | Phospho.ELM 6.0 | 770 | Phosphoserine | 11969422 | Phospho.ELM 6.0 | 793 | Phosphoserine | 11969422 | Phospho.ELM 6.0 | 556 | Phosphoserine | 11969422 | Phospho.ELM 6.0 | 654 | Phosphoserine | 11969422 | Phospho.ELM 6.0 | 555 | Phosphoserine | 11969422 | Phospho.ELM 6.0 | 727 | Phosphoserine | 11969422 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr11 |
Promoter: 65137796 - 65139796 | Agilent_014791 |
chr11 |
Promoter: 65137796 - 65139796 | GSE27584 |
chr11 |
Promoter: 65137796 - 65139796 | Agilent_014791_44K |