Entrez Gene

Basic Information
Gene ID	4296
Name	MAP3K11
Synonymous	mitogen-activated protein kinase kinase kinase 11;MAP3K11;mitogen-activated protein kinase kinase kinase 11
Definition	SH3 domain-containing proline-rich kinase\|mixed lineage kinase 3\|protein-tyrosine kinase PTK1\|src-homology 3 domain-containing proline-rich kinase
Position	11q13.1-q13.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1269G>A; p.E423E; 11:65607490-65607490	breast	carcinoma	Substitution - coding silent
c.2471_2472insG; p.Q826fs*>23; 11:65598363-65598364	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2006G>A; p.R669H; 11:65599594-65599594	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2427A>C; p.S809S; 11:65598408-65598408	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2270G>A; p.R757H; 11:65598565-65598565	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.445G>A; p.D149N; 11:65613312-65613312	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2270G>A; p.R757H; 11:65598565-65598565	ovary	other; neoplasm	Substitution - Missense
c.2046G>A; p.T682T; 11:65599554-65599554	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.965A>G; p.Y322C; 11:65608026-65608026	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2063C>T; p.T688I; 11:65599537-65599537	skin	malignant_melanoma	Substitution - Missense
c.308delG; p.G103fs*20; 11:65613449-65613449	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.451G>A; p.D151N; 11:65613306-65613306	breast	carcinoma	Substitution - Missense
c.2106G>A; p.T702T; 11:65599494-65599494	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2117C>T; p.P706L; 11:65599483-65599483	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.608G>A; p.R203Q; 11:65613149-65613149	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1648delC; p.R550fs*51; 11:65606037-65606037	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.968G>A; p.R323H; 11:65608023-65608023	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.968G>A; p.R323H; 11:65608023-65608023	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.364G>A; p.V122M; 11:65613393-65613393	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1831G>T; p.G611C; 11:65605761-65605761	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.440G>A; p.R147H; 11:65613317-65613317	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2060C>T; p.P687L; 11:65599540-65599540	skin	malignant_melanoma	Substitution - Missense
c.2060C>T; p.P687L; 11:65599540-65599540	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2189G>A; p.R730H; 11:65599411-65599411	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.915C>T; p.V305V; 11:65608273-65608273	skin	malignant_melanoma	Substitution - coding silent
c.2037C>T; p.P679P; 11:65599563-65599563	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.312C>T; p.G104G; 11:65613445-65613445	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.312C>T; p.G104G; 11:65613445-65613445	thyroid	other; neoplasm	Substitution - coding silent
c.2047C>T; p.P683S; 11:65599553-65599553	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.2135T>A; p.L712Q; 11:65599465-65599465	liver	carcinoma	Substitution - Missense
c.2135T>A; p.L712Q; 11:65599465-65599465	liver	carcinoma	Substitution - Missense
c.291C>T; p.S97S; 11:65613466-65613466	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1729C>T; p.Q577*; 11:65605956-65605956	skin	malignant_melanoma	Substitution - Nonsense
c.1729C>T; p.Q577*; 11:65605956-65605956	skin	malignant_melanoma	Substitution - Nonsense
c.1771T>C; p.Y591H; 11:65605821-65605821	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.789G>A; p.L263L; 11:65608399-65608399	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.789G>A; p.L263L; 11:65608399-65608399	breast	carcinoma; HER-positive_carcinoma	Substitution - coding silent
c.12G>A; p.L4L; 11:65613745-65613745	breast	carcinoma; HER-positive_carcinoma	Substitution - coding silent
c.1263G>A; p.E421E; 11:65607496-65607496	skin	malignant_melanoma	Substitution - coding silent
c.668C>T; p.A223V; 11:65613089-65613089	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.740-1G>T; p.?; 11:65608449-65608449	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.530T>C; p.I177T; 11:65613227-65613227	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.377G>A; p.G126E; 11:65613380-65613380	urinary_tract; bladder	carcinoma	Substitution - Missense
c.128A>G; p.N43S; 11:65613629-65613629	pancreas	carcinoma	Substitution - Missense
c.360G>A; p.E120E; 11:65613397-65613397	skin	malignant_melanoma	Substitution - coding silent
c.512T>G; p.L171R; 11:65613245-65613245	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.512T>G; p.L171R; 11:65613245-65613245	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1364G>A; p.R455H; 11:65607395-65607395	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1993_1994GG>AA; p.G665K; 11:65599606-65599607	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2405C>T; p.P802L; 11:65598430-65598430	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1204G>C; p.E402Q; 11:65607682-65607682	skin	malignant_melanoma	Substitution - Missense
c.623G>A; p.R208Q; 11:65613134-65613134	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.930G>A; p.V310V; 11:65608061-65608061	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2329G>T; p.D777Y; 11:65598506-65598506	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1003G>A; p.A335T; 11:65607988-65607988	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.885G>A; p.K295K; 11:65608303-65608303	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1341G>A; p.Q447Q; 11:65607418-65607418	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1102G>C; p.D368H; 11:65607784-65607784	parathyroid	carcinoma	Substitution - Missense
c.1123C>G; p.Q375E; 11:65607763-65607763	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1393G>A; p.D465N; 11:65607366-65607366	liver	carcinoma	Substitution - Missense
c.845C>T; p.A282V; 11:65608343-65608343	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2476delC; p.Q826fs*>22; 11:65598359-65598359	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1393G>A; p.D465N; 11:65607366-65607366	liver	carcinoma	Substitution - Missense
c.1200G>A; p.K400K; 11:65607686-65607686	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2513A>G; p.Q838R; 11:65598322-65598322	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1092C>T; p.H364H; 11:65607794-65607794	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.496C>G; p.R166G; 11:65613261-65613261	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1807C>T; p.P603S; 11:65605785-65605785	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.484C>T; p.R162C; 11:65613273-65613273	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.694G>T; p.E232*; 11:65613063-65613063	liver	carcinoma	Substitution - Nonsense
c.526A>G; p.I176V; 11:65613231-65613231	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.526A>G; p.I176V; 11:65613231-65613231	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Substitution - Missense
c.2024C>T; p.P675L; 11:65599576-65599576	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.997G>A; p.G333S; 11:65607994-65607994	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2050G>A; p.A684T; 11:65599550-65599550	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2036C>T; p.P679L; 11:65599564-65599564	skin	malignant_melanoma	Substitution - Missense
c.2036C>T; p.P679L; 11:65599564-65599564	skin	malignant_melanoma	Substitution - Missense
c.56G>A; p.S19N; 11:65613701-65613701	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.858C>T; p.Y286Y; 11:65608330-65608330	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.910G>A; p.D304N; 11:65608278-65608278	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.735C>T; p.N245N; 11:65613022-65613022	liver	carcinoma	Substitution - coding silent
c.1221C>T; p.F407F; 11:65607665-65607665	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1221C>T; p.F407F; 11:65607665-65607665	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.735C>T; p.N245N; 11:65613022-65613022	liver	carcinoma	Substitution - coding silent
c.1054G>T; p.A352S; 11:65607937-65607937	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.656C>T; p.A219V; 11:65613101-65613101	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1585C>T; p.R529W; 11:65606709-65606709	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1988C>T; p.P663L; 11:65599612-65599612	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1184T>A; p.M395K; 11:65607702-65607702	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.2049C>T; p.P683P; 11:65599551-65599551	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.674G>A; p.G225E; 11:65613083-65613083	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.628G>A; p.V210M; 11:65613129-65613129	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.1163C>T; p.P388L; 11:65607723-65607723	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.847G>A; p.A283T; 11:65608341-65608341	skin	malignant_melanoma	Substitution - Missense
c.2421G>A; p.P807P; 11:65598414-65598414	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2156C>G; p.P719R; 11:65599444-65599444	liver	carcinoma	Substitution - Missense
c.1558G>A; p.G520R; 11:65606736-65606736	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2534C>T; p.A845V; 11:65598301-65598301	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2351C>T; p.A784V; 11:65598484-65598484	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2205C>T; p.R735R; 11:65599395-65599395	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1150C>T; p.L384L; 11:65607736-65607736	skin	malignant_melanoma	Substitution - coding silent
c.1225G>A; p.E409K; 11:65607661-65607661	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2037delC; p.T680fs*>168; 11:65599563-65599563	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1742G>A; p.R581K; 11:65605850-65605850	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2070G>T; p.P690P; 11:65599530-65599530	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2039C>T; p.T680M; 11:65599561-65599561	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1080G>A; p.A360A; 11:65607806-65607806	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2048C>T; p.P683L; 11:65599552-65599552	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1133C>T; p.A378V; 11:65607753-65607753	ovary	other; neoplasm	Substitution - Missense
c.1133C>T; p.A378V; 11:65607753-65607753	ovary	other; neoplasm	Substitution - Missense
c.907A>G; p.S303G; 11:65608281-65608281	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.69T>G; p.G23G; 11:65613688-65613688	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.511C>T; p.L171L; 11:65613246-65613246	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2079C>T; p.S693S; 11:65599521-65599521	skin	malignant_melanoma	Substitution - coding silent
c.2118G>A; p.P706P; 11:65599482-65599482	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.358G>T; p.E120*; 11:65613399-65613399	breast	carcinoma	Substitution - Nonsense
c.2543G>C; p.*848S; 11:65598292-65598292	breast	carcinoma	Nonstop extension
c.1948G>A; p.A650T; 11:65599652-65599652	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2228C>T; p.P743L; 11:65598607-65598607	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1841delC; p.P614fs*27; 11:65599759-65599759	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1841delC; p.P614fs*27; 11:65599759-65599759	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2301T>A; p.P767P; 11:65598534-65598534	skin	malignant_melanoma	Substitution - coding silent
c.960G>A; p.V320V; 11:65608031-65608031	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2073C>T; p.P691P; 11:65599527-65599527	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1750C>T; p.R584C; 11:65605842-65605842	central_nervous_system; medulla	glioma; oligodendroglioma_Grade_III	Substitution - Missense
c.439C>T; p.R147C; 11:65613318-65613318	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.439C>T; p.R147C; 11:65613318-65613318	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1709C>T; p.S570F; 11:65605976-65605976	skin	malignant_melanoma	Substitution - Missense
c.1044C>T; p.P348P; 11:65607947-65607947	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1709C>T; p.S570F; 11:65605976-65605976	skin	malignant_melanoma	Substitution - Missense
c.1961C>T; p.S654L; 11:65599639-65599639	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1710C>T; p.S570S; 11:65605975-65605975	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.324C>G; p.P108P; 11:65613433-65613433	ovary	other; neoplasm	Substitution - coding silent
c.1931C>T; p.A644V; 11:65599669-65599669	ovary	other; neoplasm	Substitution - Missense
c.324C>G; p.P108P; 11:65613433-65613433	ovary	other; neoplasm	Substitution - coding silent
c.324C>G; p.P108P; 11:65613433-65613433	ovary	other; neoplasm	Substitution - coding silent
c.324C>G; p.P108P; 11:65613433-65613433	ovary	other; neoplasm	Substitution - coding silent
c.251G>T; p.W84L; 11:65613506-65613506	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1239G>C; p.K413N; 11:65607647-65607647	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1115T>C; p.I372T; 11:65607771-65607771	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.957G>A; p.E319E; 11:65608034-65608034	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.688C>T; p.H230Y; 11:65613069-65613069	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1731G>C; p.Q577H; 11:65605954-65605954	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.688C>T; p.H230Y; 11:65613069-65613069	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1976G>A; p.R659H; 11:65599624-65599624	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2240G>A; p.R747H; 11:65598595-65598595	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.543T>G; p.A181A; 11:65613214-65613214	liver	carcinoma	Substitution - coding silent
c.543T>G; p.A181A; 11:65613214-65613214	liver	carcinoma	Substitution - coding silent
c.1647C>T; p.P549P; 11:65606038-65606038	skin	malignant_melanoma	Substitution - coding silent

COSMIC somatic mutation [Top]