CYP1A1m1 and m2 polymorphisms are associated with the smoking related lung cancer.

airborne particulates generated during the frying of beef, fish and pork can induce carcinogen-metabolizing CYP1A1 in the human lung-derived cell line

CYP1A1 T3801 C polymorphism and lung cancer: a pooled analysis of 2451 cases and 3358 controls.

specific genotype combinations of CYP1A1, GSTM1 and GSTT1 alleles in the development of lung cancer in heavy smokers

no differences between the patient and control groups regarding genetic polymorphism of genes for non-small cell lung carcinoma

CYP1A1 is a suscpetibility gene for lung cancer among non-smoking Asian women and this asscociation can be influenced by environmental tobacco smoke exposure.

These new data establish an association between the CYP1A1 Ile462Val polymorphism and the risk of developing non-small cell lung cancer, especially among women

Role of the metabolic gene polymorphisms in non-smoker lung cancer patients from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens.

MspI polymorphism of CYP450 1A1 was investigated in lung cancer patients and in healthy volunteers in a population eposed to arsenic in drinking water.

Our study suggests the importance of combined CYP1A1, GSTM1 and GSTT1 polymorphisms in the development of smoking-induced lung cancer.

Concerted role of CYP1A1 and GSTM1 at-risk genotypes in squamous cell lung carcinoma predisposition.

Subjects who had the mutant alleles of the GSTP1 and CYP1A1 and homozygous wild type of MPO, showed approximately 5-fold-higher risk for lung cancer than the reference.

we found evidence of an association between the CYP1A1 variant and GSTM1 null genotypes and increased risk of lung cancer.

CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women.

Cigarette smoking or tobacco chewing or alcohol consumption was also found to interact with CYP1A1 genotypes in increasing the risk to lung cancer.

significant association between *2B/*2B and *4/*4 genotypes and the risk of developing lung cancer among Mexicans

Genetic polymorphisms in CYP1A1 are associated with lung cancer risk in Asian smokers.

CYP1A1 (Val/Val) genotype increases the susceptibility to lung cancer eightfold along with null genotype of GSTM1/GSTT1

The CYP1A1*2A gene cannot be linked with lung cancer risk in Brazilian patients at this time.

We conclude that in this sample of the Portuguese population, CYP1A1 m1 and m2 polymorphisms are too rare to be of clinical relevance, and do not seem to be associated with susceptibility to lung cancer

Findings suggested that CYP1A1 or GSTM1 variants may significantly modify the associations between level of serum trace metals (Cu, Zn, Se or Cr) and NSCLC, indicating the intriguing pathogenesis of lung cancer.

Combined effects of cigarette smoke and CYP1A1 Polymorphisms are associated with non small cell lung cancer.

CYP1A1 gene polymorphisms are associated with lung cancer.

The combination of CYP1A1 polymorphisms with cooking oil fume increased the risk of female lung cancer.

The MspI and Ile-Val polymorphism of CYP1A1 is a risk factor associated with increased lung cancer susceptibility, but these associations vary in different ethnic populations.

The combined effects of CYP1A1 gene and GSTM1 gene polymorphism are significantly associated with an increased risk to lung cancer.

This meta-analysis suggests that the CYP1A1 IleVal polymorphism might play a modest role in susceptibility to lung cancer, especially in Asians.

Non-small-cell lung cancer patients with TT CYP1A1 were better responders to nonplatinum drugs.

TP53 mutation and CDKN2A methylation specifically interact to promote lung tumorigenesis in subjects with CYP1A1 risk genotype.

CYP1A1 mutant genotype and GSTM1 null genotype with smoke has increased the risk of lung cancer, with OR being 2.406(1.321-4.382), 2.755(1.470-5.163), respectively.

This meta-analysis suggests that the MspI polymorphisms of CYP1A1 correlate with increased lung cancer susceptibility.

The genetic polymorphisms of CYP1A1-exon7, GSTM1, XRCC1-194 and XRCC1-280 might contribute to the risk of developing lung cancer in Henan population.

Report possible associations between CYP1A1 gene polymorphism and the risk of lung cancer.

CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lung squamous carcinoma and smokers [meta-analysis]

Results suggest that genetic polymorphisms in the CYP1A1, GSTM1, GSTT1 and GSTP1 metabolic genes were not significantly associated with lung cancer risk.

results indicate that the CYP1A1*2B allele (rs4646903 and rs1048943) is associated with an increased lung cancer risk and CYP2A6*4 is associated with a decreased lung cancer risk in the Bangladeshi population

A three-order interaction of CYP1A1, CYP2A6, and CYP2D6 polymorphisms appears to increase genetic susceptibility to lung cancer in patients from central south China.

Studies suggest that CYP1A1 exon7 polymorphism correlated with increased lung cancer susceptibility and there is an interaction between CYP1A1 exon7 polymorphisms and smoking, but these associations vary in different genders.

meta-analysis suggests the participation of A2455G of CYP1A1 in the susceptibility for some cancers, such as breast cancer, colorectal cancer, lung cancer, and so on

Carcinogens in smoke increase cytochrome P450 1A1 activity, which might be considered to play a role in cigarette smoking-induced lung cancer.

CYP1A1 m1 and m2 polymorphisms contribute to smoking related lung cancer risk in the Egyptian population

Data indicate that both cytochrome P450 1A1 (CYP1A1) MspI and glutathione S-transferase M1 (GSTM1) genetic polymorphisms were independently associated with the risk of lung cancer.

The CYP1A1 Ile462Val variant was associated with a low risk of developing non-small cell lung cancer in a Chinese population.

The CYP1A1 gene deletion is a lung cancer risk factor, and interacts with smoking in non-small cell lung cancer development.

Meta-analysis showed that there was an interaction between the CYP1A1 MspI and smoking on the risk of lung cancer in the Chinese population. [Meta-Analysis]

results suggest the polymorphic variants in the CYP1A1 gene along with GSTM1 and GSTT1 do act as a genetic modifier for lung cancer susceptibility and are strongly associated with lung cancer risk in population of North Indians; positive results in the gene-gene interactions analysis seem to indicate that these interactions play an important role with lung cancer development

Data show a combined role of cytochrome P 450 1A1 (CYP1A1), Glutathione -S -transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms and smoking status can be attributed for the cause of lung cancer.

Polymorphism in the CYP1A1 gene is an important risk modifier for lung cancer.

The analysis results showed that the following polymorphisms were correlated with susceptibility to lung cancer: rs4646903 in CYP1A1 (P < 0.001), rs1048943 in CYP1A1 (P < 0.001), rs1695 in GSTP1 (P < 0.05), rs13181 in ERCC2 (P < 0.001), and rs25487 in XRCC1 (P < 0.05); no such correlation existed in rs861539 in XRCC3 (P > 0.05).

Our meta-analysis revealed strong association of rs1048943 in CYP1A1, but a suggestive association of deletion polymorphisms in GSTT1 and GSTM1 with lung cancer, which provides a comprehensive insight on the overall effect of the polymorphic variants, reported in various case-control studies on Indian population, on the risk of lung cancer development

The correlation of combined OGG1, CYP1A1 and GSTP1 gene variants and risk of lung cancer of male Iraqi waterpipe tobacco smokers.

Association between the combined effects of GSTM1 present/null and CYP1A1 MspI polymorphisms with lung cancer risk: an updated meta-analysis.

up-regulated expression during benzo(a)pyrene induced pulmonary carcinogenesis