lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1543
Symbol	CYP1A1
Synonymous	AHH\|AHRR\|CP11\|CYP1\|P1-450\|P450-C\|P450DX
Full name	cytochrome P450, family 1, subfamily A, polypeptide 1
Gene description	CYPIA1\|aryl hydrocarbon hydroxylase\|cytochrome P1-450, dioxin-inducible\|cytochrome P450 1A1\|cytochrome P450 form 6\|cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1\|cytochrome P450-C\|cytochrome P450-P1\|flavoprotein-linked monooxyge
Cytoband	15q24.1
Gene type	protein-coding
Synonymous	MIM:108330; HGNC:HGNC:2595; Ensembl:ENSG00000140465; HPRD:00148; Vega:OTTHUMG00000142812

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.620A>G; p.Y207C; 15:74722478-74722478	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1322A>T; p.K441M; 15:74720706-74720706	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.496G>A; p.E166K; 15:74722602-74722602	breast	carcinoma	Substitution - Missense
c.1526A>T; p.Q509L; 15:74720502-74720502	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.746A>T; p.N249I; 15:74722352-74722352	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.316C>T; p.R106W; 15:74722782-74722782	skin	malignant_melanoma	Substitution - Missense
c.1375G>A; p.G459S; 15:74720653-74720653	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.614G>A; p.R205Q; 15:74722484-74722484	thyroid	other; neoplasm	Substitution - Missense
c.1456G>A; p.V486M; 15:74720572-74720572	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.230G>A; p.R77Q; 15:74722868-74722868	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.167G>A; p.G56E; 15:74722931-74722931	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1144G>A; p.V382I; 15:74721221-74721221	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1144G>A; p.V382I; 15:74721221-74721221	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.578C>T; p.S193L; 15:74722520-74722520	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.650T>A; p.L217Q; 15:74722448-74722448	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.722G>A; p.R241H; 15:74722376-74722376	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.722G>A; p.R241H; 15:74722376-74722376	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1096C>T; p.P366S; 15:74721269-74721269	skin	malignant_melanoma	Substitution - Missense
c.128C>T; p.P43L; 15:74722970-74722970	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.733A>T; p.N245Y; 15:74722365-74722365	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1029C>T; p.I343I; 15:74721427-74721427	skin	malignant_melanoma	Substitution - coding silent
c.612C>T; p.G204G; 15:74722486-74722486	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1384A>G; p.I462V; 15:74720644-74720644	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1384A>G; p.I462V; 15:74720644-74720644	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.474C>T; p.Y158Y; 15:74722624-74722624	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1378G>A; p.E460K; 15:74720650-74720650	skin	malignant_melanoma	Substitution - Missense
c.1183A>C; p.S395R; 15:74721037-74721037	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.557C>T; p.P186L; 15:74722541-74722541	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1363_1364insGGAAGTG; p.C457fs*6; 15:74720664-74720665	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Insertion - Frameshift
c.739T>C; p.S247P; 15:74722359-74722359	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1431G>T; p.R477R; 15:74720597-74720597	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.262G>A; p.G88S; 15:74722836-74722836	skin	malignant_melanoma	Substitution - Missense
c.617G>A; p.R206H; 15:74722481-74722481	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.766G>T; p.E256*; 15:74722332-74722332	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.83_84CC>GG; p.A28G; 15:74723014-74723015	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.617G>A; p.R206H; 15:74722481-74722481	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1429C>T; p.R477W; 15:74720599-74720599	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1429C>T; p.R477W; 15:74720599-74720599	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1314T>A; p.A438A; 15:74720714-74720714	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.135C>A; p.G45G; 15:74722963-74722963	pancreas	carcinoma	Substitution - coding silent
c.855G>C; p.L285L; 15:74721688-74721688	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1088C>A; p.S363Y; 15:74721277-74721277	urinary_tract; bladder	carcinoma	Substitution - Missense
c.478G>C; p.E160Q; 15:74722620-74722620	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.741C>A; p.S247S; 15:74722357-74722357	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1519C>A; p.Q507K; 15:74720509-74720509	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1087T>A; p.S363T; 15:74721278-74721278	pancreas	carcinoma	Substitution - Missense
c.510G>C; p.L170L; 15:74722588-74722588	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.435C>T; p.F145F; 15:74722663-74722663	skin	malignant_melanoma	Substitution - coding silent
c.112A>G; p.K38E; 15:74722986-74722986	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1079C>T; p.S360F; 15:74721286-74721286	skin	malignant_melanoma	Substitution - Missense
c.90A>G; p.R30R; 15:74723008-74723008	breast	carcinoma	Substitution - coding silent
c.1072C>T; p.R358W; 15:74721293-74721293	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.59G>T; p.C20F; 15:74723039-74723039	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1104G>A; p.M368I; 15:74721261-74721261	skin; mucosal	malignant_melanoma	Substitution - Missense
c.140C>G; p.P47R; 15:74722958-74722958	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.892G>A; p.A298T; 15:74721651-74721651	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.217G>A; p.V73M; 15:74722881-74722881	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.217G>A; p.V73M; 15:74722881-74722881	soft_tissue; blood_vessel	angiosarcoma	Substitution - Missense
c.217G>A; p.V73M; 15:74722881-74722881	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1382C>A; p.T461N; 15:74720646-74720646	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.127C>T; p.P43S; 15:74722971-74722971	skin	malignant_melanoma	Substitution - Missense
c.278G>A; p.R93Q; 15:74722820-74722820	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.52A>G; p.I18V; 15:74723046-74723046	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1067G>A; p.R356Q; 15:74721298-74721298	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.114G>T; p.K38N; 15:74722984-74722984	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.489G>A; p.V163V; 15:74722609-74722609	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.843C>T; p.I281I; 15:74721700-74721700	skin	malignant_melanoma	Substitution - coding silent
c.407G>A; p.R136H; 15:74722691-74722691	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.292C>T; p.R98W; 15:74722806-74722806	pancreas	NS	Substitution - Missense
c.285C>T; p.A95A; 15:74722813-74722813	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.54C>T; p.I18I; 15:74723044-74723044	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.827G>A; p.G276D; 15:74721716-74721716	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1444G>A; p.V482M; 15:74720584-74720584	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1444G>A; p.V482M; 15:74720584-74720584	prostate	carcinoma	Substitution - Missense
c.795G>A; p.M265I; 15:74722303-74722303	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.952+2T>C; p.?; 15:74721589-74721589	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.826G>T; p.G276C; 15:74721717-74721717	breast	carcinoma	Substitution - Missense
c.1160C>T; p.P387L; 15:74721205-74721205	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1033G>T; p.E345*; 15:74721423-74721423	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1430G>T; p.R477L; 15:74720598-74720598	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.234T>G; p.I78M; 15:74722864-74722864	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.835C>T; p.R279W; 15:74721708-74721708	skin	malignant_melanoma	Substitution - Missense
c.654C>A; p.V218V; 15:74722444-74722444	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.672C>T; p.F224F; 15:74722426-74722426	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.672C>T; p.F224F; 15:74722426-74722426	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.94C>G; p.Q32E; 15:74723004-74723004	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.94C>G; p.Q32E; 15:74723004-74723004	urinary_tract; bladder	carcinoma	Substitution - Missense
c.94C>G; p.Q32E; 15:74723004-74723004	urinary_tract; bladder	carcinoma	Substitution - Missense
c.887A>T; p.E296V; 15:74721656-74721656	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1148C>T; p.P383L; 15:74721217-74721217	skin	malignant_melanoma	Substitution - Missense
c.401G>A; p.R134H; 15:74722697-74722697	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.401G>A; p.R134H; 15:74722697-74722697	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.637G>T; p.E213*; 15:74722461-74722461	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1435G>A; p.E479K; 15:74720593-74720593	skin	malignant_melanoma	Substitution - Missense
c.524A>C; p.Q175P; 15:74722574-74722574	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.616C>T; p.R206C; 15:74722482-74722482	skin; trunk	malignant_melanoma	Substitution - Missense
c.83C>T; p.A28V; 15:74723015-74723015	oesophagus	carcinoma	Substitution - Missense
c.1116C>T; p.I372I; 15:74721249-74721249	skin	malignant_melanoma	Substitution - coding silent
c.1254G>A; p.Q418Q; 15:74720774-74720774	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.750C>A; p.A250A; 15:74722348-74722348	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.134G>A; p.G45D; 15:74722964-74722964	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1306G>C; p.D436H; 15:74720722-74720722	ovary	carcinoma; clear_cell_carcinoma	Substitution - Missense
c.151C>T; p.H51Y; 15:74722947-74722947	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.842T>A; p.I281N; 15:74721701-74721701	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.495G>T; p.K165N; 15:74722603-74722603	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1518C>T; p.F506F; 15:74720510-74720510	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1130G>A; p.R377Q; 15:74721235-74721235	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1130G>A; p.R377Q; 15:74721235-74721235	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1237C>G; p.Q413E; 15:74720983-74720983	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1532G>T; p.R511L; 15:74720496-74720496	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.444C>T; p.A148A; 15:74722654-74722654	skin	malignant_melanoma	Substitution - coding silent
c.526G>A; p.E176K; 15:74722572-74722572	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1098C>A; p.P366P; 15:74721267-74721267	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.37_38CT>AC; p.L13T; 15:74723060-74723061	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1007A>G; p.N336S; 15:74721449-74721449	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.573G>A; p.V191V; 15:74722525-74722525	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.474C>A; p.Y158*; 15:74722624-74722624	breast	carcinoma; ductal_carcinoma	Substitution - Nonsense
c.1313C>T; p.A438V; 15:74720715-74720715	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1401C>G; p.V467V; 15:74720627-74720627	central_nervous_system; brain	glioma	Substitution - coding silent
c.891C>T; p.N297N; 15:74721652-74721652	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1163A>G; p.H388R; 15:74721202-74721202	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.747T>G; p.N249K; 15:74722351-74722351	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1411C>T; p.L471L; 15:74720617-74720617	skin	malignant_melanoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation