lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	7297
Symbol	TYK2
Synonymous	IMD35\|JTK1
Full name	tyrosine kinase 2
Gene description	non-receptor tyrosine-protein kinase TYK2
Cytoband	19p13.2
Gene type	protein-coding
Synonymous	MIM:176941; HGNC:HGNC:12440; Ensembl:ENSG00000105397; HPRD:01490; Vega:OTTHUMG00000166373

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.2039G>T; p.G680V; 19:10361519-10361519	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2039G>T; p.G680V; 19:10361519-10361519	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1181G>A; p.S394N; 19:10364879-10364879	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.706A>G; p.N236D; 19:10365822-10365822	prostate	carcinoma	Substitution - Missense
c.3201-8C>T; p.?; 19:10352559-10352559	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.769G>T; p.V257F; 19:10365759-10365759	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.864G>A; p.G288G; 19:10365664-10365664	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2733C>T; p.V911V; 19:10354217-10354217	skin	malignant_melanoma	Substitution - coding silent
c.2230C>T; p.R744W; 19:10358084-10358084	breast	carcinoma	Substitution - Missense
c.3429+1G>T; p.?; 19:10351051-10351051	breast	carcinoma; ductal_carcinoma	Unknown
c.3429+1G>T; p.?; 19:10351051-10351051	breast	carcinoma; ductal_carcinoma	Unknown
c.217C>G; p.L73V; 19:10368395-10368395	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2068G>T; p.V690L; 19:10359282-10359282	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.217C>G; p.L73V; 19:10368395-10368395	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.3325C>T; p.L1109F; 19:10351156-10351156	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1480C>T; p.P494S; 19:10362453-10362453	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.2384T>C; p.M795T; 19:10357846-10357846	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2618-1G>C; p.?; 19:10354610-10354610	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.667A>G; p.I223V; 19:10365861-10365861	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.339T>G; p.H113Q; 19:10368181-10368181	thyroid	other; neoplasm	Substitution - Missense
c.959G>T; p.G320V; 19:10365569-10365569	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2434G>T; p.E812*; 19:10357796-10357796	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2108G>T; p.R703L; 19:10359242-10359242	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2700C>T; p.I900I; 19:10354527-10354527	skin	malignant_melanoma	Substitution - coding silent
c.735C>T; p.F245F; 19:10365793-10365793	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1124C>T; p.A375V; 19:10364936-10364936	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.3315delC; p.T1106fs*7; 19:10352437-10352437	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2183A>G; p.K728R; 19:10358131-10358131	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2184G>T; p.K728N; 19:10358130-10358130	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3156C>T; p.H1052H; 19:10352970-10352970	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3156C>T; p.H1052H; 19:10352970-10352970	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.115G>A; p.G39S; 19:10378292-10378292	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.821G>A; p.R274H; 19:10365707-10365707	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.1035_1036insG; p.N346fs*34; 19:10365024-10365025	breast	carcinoma	Insertion - Frameshift
c.1565C>T; p.S522F; 19:10362368-10362368	skin	malignant_melanoma	Substitution - Missense
c.1677C>A; p.S559S; 19:10362174-10362174	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2902G>A; p.D968N; 19:10354048-10354048	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1168G>T; p.E390*; 19:10364892-10364892	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Nonsense
c.2404G>T; p.A802S; 19:10357826-10357826	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1897C>T; p.R633C; 19:10361832-10361832	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2385G>A; p.M795I; 19:10357845-10357845	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2245G>C; p.E749Q; 19:10358069-10358069	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2719C>A; p.H907N; 19:10354231-10354231	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1579C>T; p.R527W; 19:10362354-10362354	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2044G>C; p.E682Q; 19:10361514-10361514	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.3227A>G; p.Y1076C; 19:10352525-10352525	skin	malignant_melanoma	Substitution - Missense
c.2996A>G; p.Q999R; 19:10353559-10353559	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2102G>C; p.R701T; 19:10359248-10359248	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.309C>T; p.F103F; 19:10368303-10368303	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.417G>T; p.Q139H; 19:10368103-10368103	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1779C>T; p.S593S; 19:10361950-10361950	liver	carcinoma	Substitution - coding silent
c.1779C>T; p.S593S; 19:10361950-10361950	liver	carcinoma	Substitution - coding silent
c.1501C>T; p.R501W; 19:10362432-10362432	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.3290A>G; p.H1097R; 19:10352462-10352462	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2383A>G; p.M795V; 19:10357847-10357847	ovary	other; neoplasm	Substitution - Missense
c.3290A>G; p.H1097R; 19:10352462-10352462	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.490G>A; p.V164M; 19:10366556-10366556	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.753C>T; p.S251S; 19:10365775-10365775	skin	malignant_melanoma	Substitution - coding silent
c.1126T>C; p.Y376H; 19:10364934-10364934	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3168C>T; p.R1056R; 19:10352958-10352958	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2436G>C; p.E812D; 19:10357794-10357794	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2176G>A; p.E726K; 19:10358138-10358138	skin	malignant_melanoma	Substitution - Missense
c.3539C>T; p.A1180V; 19:10350859-10350859	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.3159_3160GT>CC; p.E1053_Y1054>DH; 19:10352966-10352967	ovary	carcinoma; serous_carcinoma	Complex - compound substitution
c.637G>A; p.D213N; 19:10365891-10365891	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1264G>A; p.G422S; 19:10364717-10364717	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1264G>A; p.G422S; 19:10364717-10364717	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1264G>A; p.G422S; 19:10364717-10364717	large_intestine; colon	carcinoma	Substitution - Missense
c.1264G>A; p.G422S; 19:10364717-10364717	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1778C>G; p.S593C; 19:10361951-10361951	liver	carcinoma	Substitution - Missense
c.1778C>G; p.S593C; 19:10361951-10361951	liver	carcinoma	Substitution - Missense
c.2224C>T; p.L742L; 19:10358090-10358090	pancreas	carcinoma	Substitution - coding silent
c.2224C>T; p.L742L; 19:10358090-10358090	pancreas	carcinoma	Substitution - coding silent
c.1331T>G; p.V444G; 19:10364650-10364650	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2725G>A; p.G909S; 19:10354225-10354225	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_B_cell_leukaemia	Substitution - Missense
c.3160T>C; p.Y1054H; 19:10352966-10352966	ovary	other; neoplasm	Substitution - Missense
c.2858C>T; p.T953M; 19:10354092-10354092	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3160T>C; p.Y1054H; 19:10352966-10352966	ovary	other; neoplasm	Substitution - Missense
c.3406C>A; p.R1136R; 19:10351075-10351075	pancreas	carcinoma	Substitution - coding silent
c.2869G>T; p.E957*; 19:10354081-10354081	thyroid	other; neoplasm	Substitution - Nonsense
c.1576G>A; p.V526I; 19:10362357-10362357	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3046G>A; p.A1016T; 19:10353080-10353080	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1038C>T; p.N346N; 19:10365022-10365022	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.727C>T; p.R243W; 19:10365801-10365801	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.1807G>A; p.V603M; 19:10361922-10361922	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.727C>T; p.R243W; 19:10365801-10365801	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.231C>T; p.F77F; 19:10368381-10368381	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1398C>T; p.P466P; 19:10362627-10362627	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1398C>T; p.P466P; 19:10362627-10362627	ovary	other; neoplasm	Substitution - coding silent
c.288T>C; p.D96D; 19:10368324-10368324	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.3287C>T; p.T1096M; 19:10352465-10352465	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3048G>A; p.A1016A; 19:10353078-10353078	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1631G>T; p.C544F; 19:10362302-10362302	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.138C>T; p.F46F; 19:10378269-10378269	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1486G>A; p.G496S; 19:10362447-10362447	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.138C>T; p.F46F; 19:10378269-10378269	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2051T>G; p.I684S; 19:10359299-10359299	breast	carcinoma	Substitution - Missense
c.943G>A; p.E315K; 19:10365585-10365585	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2051T>G; p.I684S; 19:10359299-10359299	breast	carcinoma	Substitution - Missense
c.3315_3316insC; p.T1106fs*5; 19:10352436-10352437	large_intestine; rectum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2051T>G; p.I684S; 19:10359299-10359299	prostate	adenoma	Substitution - Missense
c.1084G>T; p.V362F; 19:10364976-10364976	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.943G>A; p.E315K; 19:10365585-10365585	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3315_3316insC; p.T1106fs*5; 19:10352436-10352437	breast	carcinoma	Insertion - Frameshift
c.3334A>G; p.I1112V; 19:10351147-10351147	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3334A>G; p.I1112V; 19:10351147-10351147	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2823C>G; p.R941R; 19:10354127-10354127	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3306G>T; p.Q1102H; 19:10352446-10352446	skin	malignant_melanoma	Substitution - Missense
c.3456G>T; p.W1152C; 19:10350942-10350942	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2603G>T; p.R868L; 19:10356582-10356582	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2707C>T; p.L903L; 19:10354520-10354520	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1248C>T; p.F416F; 19:10364733-10364733	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.756G>A; p.Q252Q; 19:10365772-10365772	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1248C>T; p.F416F; 19:10364733-10364733	skin	malignant_melanoma	Substitution - coding silent
c.1518C>T; p.P506P; 19:10362415-10362415	skin	malignant_melanoma	Substitution - coding silent
c.3080G>A; p.R1027H; 19:10353046-10353046	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.2591G>A; p.R864H; 19:10356594-10356594	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3080G>A; p.R1027H; 19:10353046-10353046	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.1207C>A; p.L403M; 19:10364853-10364853	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1683C>G; p.L561L; 19:10362168-10362168	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1341C>T; p.I447I; 19:10364640-10364640	skin	malignant_melanoma	Substitution - coding silent
c.2855G>A; p.R952H; 19:10354095-10354095	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1908G>C; p.E636D; 19:10361821-10361821	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.3476G>A; p.R1159H; 19:10350922-10350922	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2375G>T; p.S792I; 19:10357855-10357855	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1898G>A; p.R633H; 19:10361831-10361831	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma; medullomyoblastoma	Substitution - Missense
c.1898G>A; p.R633H; 19:10361831-10361831	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1467G>A; p.Q489Q; 19:10362558-10362558	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2895C>T; p.C965C; 19:10354055-10354055	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.317+8G>A; p.?; 19:10368287-10368287	urinary_tract; bladder	carcinoma	Unknown
c.403G>C; p.D135H; 19:10368117-10368117	urinary_tract; bladder	carcinoma	Substitution - Missense
c.401C>T; p.S134L; 19:10368119-10368119	oesophagus; upper_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3173G>A; p.R1058H; 19:10352953-10352953	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1792G>A; p.G598S; 19:10361937-10361937	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1087G>A; p.G363S; 19:10364973-10364973	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.513G>A; p.S171S; 19:10366533-10366533	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.840G>C; p.L280L; 19:10365688-10365688	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1106C>T; p.P369L; 19:10364954-10364954	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1570C>T; p.P524S; 19:10362363-10362363	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1009G>A; p.E337K; 19:10365519-10365519	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2295C>T; p.G765G; 19:10358019-10358019	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.3157G>A; p.E1053K; 19:10352969-10352969	breast	carcinoma	Substitution - Missense
c.1590G>T; p.G530G; 19:10362343-10362343	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.225C>T; p.A75A; 19:10368387-10368387	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.692G>A; p.R231Q; 19:10365836-10365836	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3122A>C; p.D1041A; 19:10353004-10353004	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2176-1G>A; p.?; 19:10358139-10358139	skin	malignant_melanoma	Unknown
c.2195A>G; p.H732R; 19:10358119-10358119	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2195A>G; p.H732R; 19:10358119-10358119	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.658C>T; p.R220C; 19:10365870-10365870	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2195A>G; p.H732R; 19:10358119-10358119	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2289C>T; p.G763G; 19:10358025-10358025	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2289C>T; p.G763G; 19:10358025-10358025	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2919G>A; p.S973S; 19:10353636-10353636	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1278G>T; p.L426L; 19:10364703-10364703	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1278G>T; p.L426L; 19:10364703-10364703	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.196A>T; p.I66F; 19:10368416-10368416	skin	malignant_melanoma	Substitution - Missense
c.1309G>A; p.E437K; 19:10364672-10364672	breast	carcinoma	Substitution - Missense
c.1037A>C; p.N346T; 19:10365023-10365023	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2521C>T; p.L841L; 19:10356664-10356664	liver	carcinoma	Substitution - coding silent
c.2521C>T; p.L841L; 19:10356664-10356664	liver	carcinoma	Substitution - coding silent
c.1037A>C; p.N346T; 19:10365023-10365023	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1037A>C; p.N346T; 19:10365023-10365023	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1037A>C; p.N346T; 19:10365023-10365023	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.724C>A; p.L242M; 19:10365804-10365804	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2604G>A; p.R868R; 19:10356581-10356581	skin	malignant_melanoma	Substitution - coding silent
c.2161G>A; p.A721T; 19:10359189-10359189	skin	malignant_melanoma	Substitution - Missense
c.2810G>C; p.G937A; 19:10354140-10354140	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.3110T>G; p.V1037G; 19:10353016-10353016	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2516C>T; p.P839L; 19:10356669-10356669	skin	malignant_melanoma	Substitution - Missense
c.3206C>G; p.A1069G; 19:10352546-10352546	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1127A>G; p.Y376C; 19:10364933-10364933	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1327C>G; p.L443V; 19:10364654-10364654	breast	carcinoma	Substitution - Missense
c.2602C>T; p.R868W; 19:10356583-10356583	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.104C>T; p.A35V; 19:10378303-10378303	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.1101C>T; p.D367D; 19:10364959-10364959	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.3406C>T; p.R1136W; 19:10351075-10351075	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1273C>T; p.R425C; 19:10364708-10364708	urinary_tract; bladder	carcinoma	Substitution - Missense
c.829G>A; p.V277M; 19:10365699-10365699	prostate	carcinoma	Substitution - Missense
c.3545C>T; p.S1182L; 19:10350853-10350853	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.670C>T; p.R224W; 19:10365858-10365858	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3030C>A; p.G1010G; 19:10353096-10353096	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.3148G>A; p.E1050K; 19:10352978-10352978	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.328C>T; p.R110W; 19:10368192-10368192	skin	malignant_melanoma	Substitution - Missense
c.3148G>A; p.E1050K; 19:10352978-10352978	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.828C>T; p.P276P; 19:10365700-10365700	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.828C>T; p.P276P; 19:10365700-10365700	skin	malignant_melanoma	Substitution - coding silent
c.295C>A; p.L99M; 19:10368317-10368317	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2258C>T; p.P753L; 19:10358056-10358056	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2737T>C; p.L913L; 19:10354213-10354213	skin	malignant_melanoma	Substitution - coding silent
c.2262C>T; p.F754F; 19:10358052-10358052	breast	carcinoma	Substitution - coding silent
c.311G>T; p.R104L; 19:10368301-10368301	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1693C>T; p.R565W; 19:10362158-10362158	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1693C>T; p.R565W; 19:10362158-10362158	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.238C>G; p.Q80E; 19:10368374-10368374	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3247G>C; p.D1083H; 19:10352505-10352505	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2098C>T; p.R700W; 19:10359252-10359252	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.2439C>T; p.A813A; 19:10357791-10357791	skin; arm	malignant_melanoma	Substitution - coding silent
c.1443C>T; p.Y481Y; 19:10362582-10362582	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1239G>A; p.A413A; 19:10364742-10364742	breast	carcinoma	Substitution - coding silent
c.3471C>T; p.S1157S; 19:10350927-10350927	skin	malignant_melanoma	Substitution - coding silent
c.2579G>A; p.R860H; 19:10356606-10356606	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.317+1G>T; p.?; 19:10368294-10368294	lung	carcinoma; adenocarcinoma	Unknown
c.3318G>A; p.T1106T; 19:10352434-10352434	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1580G>A; p.R527Q; 19:10362353-10362353	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2863T>C; p.Y955H; 19:10354087-10354087	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.811G>T; p.G271C; 19:10365717-10365717	skin	malignant_melanoma	Substitution - Missense
c.44T>C; p.V15A; 19:10378363-10378363	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.2683C>T; p.R895C; 19:10354544-10354544	central_nervous_system; brain	glioma	Substitution - Missense
c.3560G>T; p.C1187F; 19:10350838-10350838	lung	carcinoma; undifferentiated_carcinoma	Substitution - Missense
c.3036C>A; p.A1012A; 19:10353090-10353090	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1156G>T; p.V386L; 19:10364904-10364904	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.870C>A; p.P290P; 19:10365658-10365658	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1843G>A; p.D615N; 19:10361886-10361886	pancreas	carcinoma	Substitution - Missense
c.880C>T; p.R294W; 19:10365648-10365648	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.3191C>T; p.P1064L; 19:10352935-10352935	skin	malignant_melanoma	Substitution - Missense
c.42C>T; p.P14P; 19:10378365-10378365	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1025G>A; p.S342N; 19:10365035-10365035	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1702C>T; p.R568W; 19:10362149-10362149	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.3505C>T; p.L1169L; 19:10350893-10350893	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2785G>A; p.V929M; 19:10354165-10354165	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.582C>A; p.L194L; 19:10366464-10366464	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.972C>G; p.I324M; 19:10365556-10365556	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2940C>T; p.Y980Y; 19:10353615-10353615	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.582C>T; p.L194L; 19:10366464-10366464	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2631C>T; p.V877V; 19:10354596-10354596	skin	malignant_melanoma	Substitution - coding silent
c.2511C>T; p.S837S; 19:10356674-10356674	breast	carcinoma	Substitution - coding silent
c.46G>T; p.G16W; 19:10378361-10378361	ovary	other; neoplasm	Substitution - Missense
c.2716-6G>A; p.?; 19:10354240-10354240	stomach	adenocarcinoma	Unknown
c.163G>A; p.E55K; 19:10378244-10378244	eye; uveal_tract	malignant_melanoma; spindle	Substitution - Missense
c.1722C>G; p.L574L; 19:10362129-10362129	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.2895C>A; p.C965*; 19:10354055-10354055	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Nonsense
c.531C>T; p.H177H; 19:10366515-10366515	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.2974C>T; p.R992W; 19:10353581-10353581	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1981C>T; p.L661F; 19:10361577-10361577	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1252T>C; p.S418P; 19:10364729-10364729	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.575G>A; p.C192Y; 19:10366471-10366471	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.2458C>T; p.P820S; 19:10357772-10357772	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3149A>G; p.E1050G; 19:10352977-10352977	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3467C>T; p.A1156V; 19:10350931-10350931	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3117C>T; p.I1039I; 19:10353009-10353009	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.3117C>T; p.I1039I; 19:10353009-10353009	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2488C>T; p.Q830*; 19:10356697-10356697	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Nonsense
c.202C>T; p.P68S; 19:10368410-10368410	skin	malignant_melanoma	Substitution - Missense
c.3117C>T; p.I1039I; 19:10353009-10353009	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1155C>T; p.H385H; 19:10364905-10364905	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2578C>T; p.R860C; 19:10356607-10356607	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2932A>G; p.M978V; 19:10353623-10353623	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3145C>T; p.P1049S; 19:10352981-10352981	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.603C>T; p.P201P; 19:10366443-10366443	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2763C>T; p.D921D; 19:10354187-10354187	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.3437A>G; p.H1146R; 19:10350961-10350961	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.893T>A; p.V298E; 19:10365635-10365635	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.3055T>C; p.Y1019H; 19:10353071-10353071	breast	carcinoma	Substitution - Missense
c.481G>T; p.V161L; 19:10366565-10366565	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation