| Gene ID | 7297 |
| Symbol | TYK2 |
| Synonymous | IMD35|JTK1 |
| Full name | tyrosine kinase 2 |
| Gene description | non-receptor tyrosine-protein kinase TYK2 |
| Cytoband | 19p13.2 |
| Gene type | protein-coding |
| Synonymous | MIM:176941; HGNC:HGNC:12440; Ensembl:ENSG00000105397; HPRD:01490; Vega:OTTHUMG00000166373 |
Pathways and Diseases | Detail |
|---|---|
Pathway | Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630 |
Pathway | no2-dependent il-12 pathway in nk cells;PID BioCarta;100093 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | IL27-mediated signaling events;PID Curated;200023 |
Pathway | il22 soluble receptor signaling pathway;PID BioCarta;100131 |
Pathway | IL23-mediated signaling events;PID Curated;200131 |
Pathway | IL6-mediated signaling events;PID Curated;200124 |
Pathway | il12 and stat4 dependent signaling pathway in th1 development;PID BioCarta;100133 |
Pathway | IL12-mediated signaling events;PID Curated;200034 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | ifn alpha signaling pathway;PID BioCarta;100139 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | stat3 signaling pathway;PID BioCarta;100028 |
Disease | Autoimmune disease;FunDO |
Disease | Lupus erythematosus;FunDO |
Disease | Other well-defined immunodeficiency syndromes;KEGG DISEASE;H00107 |
Disease | Type 1 diabetes;NHGRI |
Disease | Prostate cancer;FunDO |
Disease | Thrombocythemia, Hemorrhagic;FunDO |
Disease | type 1 diabetes;GAD |
Disease | IMMUNE;GAD |
Disease | Immune system diseases;KEGG DISEASE |
Disease | lupus erythematosus;GAD |
Disease | Sarcoidosis;FunDO |
Disease | Primary immunodeficiency;KEGG DISEASE |
Disease | Tyrosine kinase 2 deficiency;OMIM |
Sequence Information | |
|---|---|
Nucleotide Sequence | >7297 : length: 4262 AAGCAGTAGCTACCCGCGGGAGCGGGGAGGGGTCCGGGTTCGAGCTTGTGTTCCCCCGGAAGGGTGAGTCTGGACGCGGGCGCGGAAGGAGCGCGGCCGGAGGTCCTCAGGAAGAAGCCG CGGGGACTGGCTGCGCTTGACAGGCTGCACTTGGATGGGAGCACCTGGTGCCTCGGGACTGCTCCGATGCCCGGGTCTGTGCTGAATGTGTAATATGCGGAACTATATTGAAACATTACA ACCATCTTTTGATGGCAACACCCTGAGGACCTCCCTTTTCCAGATGGGGAAACTGAGGCCCAGAATTGCTAAGTGGCTTGCTTGAGTTGACACAGGGAGCTCCAGGACTCACCCTCAGCT GAGCCACCTGCCGGGAGCATGCCTCTGCGCCACTGGGGGATGGCCAGGGGCAGTAAGCCCGTTGGGGATGGAGCCCAGCCCATGGCTGCCATGGGAGGCCTGAAGGTGCTTCTGCACTGG GCTGGTCCAGGCGGCGGGGAGCCCTGGGTCACTTTCAGTGAGTCATCGCTGACAGCTGAGGAAGTCTGCATCCACATTGCACATAAAGTTGGTATCACTCCTCCTTGCTTCAATCTCTTT GCCCTCTTCGATGCTCAGGCCCAAGTCTGGTTGCCCCCAAACCACATCCTAGAGATCCCCAGAGATGCAAGCCTGATGCTATATTTCCGCATAAGGTTTTATTTCCGGAACTGGCATGGC ATGAATCCTCGGGAACCGGCTGTGTACCGTTGTGGGCCCCCAGGAACCGAGGCATCCTCAGATCAGACAGCACAGGGGATGCAACTCCTGGACCCAGCCTCATTTGAGTACCTCTTTGAG CAGGGCAAGCATGAGTTTGTGAATGACGTGGCATCACTGTGGGAGCTGTCGACCGAGGAGGAGATCCACCACTTTAAGAATGAGAGCCTGGGCATGGCCTTTCTGCACCTCTGTCACCTC GCTCTCCGCCATGGCATCCCCCTGGAGGAGGTGGCCAAGAAGACCAGCTTCAAGGACTGCATCCCGCGCTCCTTCCGCCGGCATATCCGGCAGCACAGCGCCCTGACCCGGCTGCGCCTT CGGAACGTCTTCCGCAGGTTCCTGCGGGACTTCCAGCCGGGCCGACTCTCCCAGCAGATGGTCATGGTCAAATACCTAGCCACACTCGAGCGGCTGGCACCCCGCTTCGGCACAGAGCGT GTGCCCGTGTGCCACCTGAGGCTGCTGGCCCAGGCCGAGGGGGAGCCCTGCTACATCCGGGACAGTGGGGTGGCCCCTACAGACCCTGGCCCTGAGTCTGCTGCTGGGCCCCCAACCCAC GAGGTGCTGGTGACAGGCACTGGTGGCATCCAGTGGTGGCCAGTAGAGGAGGAGGTGAACAAGGAGGAGGGTTCTAGTGGCAGCAGTGGCAGGAACCCCCAAGCCAGCCTGTTTGGGAAG AAGGCCAAGGCTCACAAGGCAGTCGGCCAGCCGGCAGACAGGCCGCGGGAGCCACTGTGGGCCTACTTCTGTGACTTCCGGGACATCACCCACGTGGTGCTGAAAGAGCACTGTGTCAGC ATCCACCGGCAGGACAACAAGTGCCTGGAGCTGAGCTTGCCTTCCCGGGCTGCGGCGCTGTCCTTCGTGTCGCTGGTGGACGGCTATTTCCGCCTGACGGCCGACTCCAGCCACTACCTG TGCCACGAGGTGGCTCCCCCACGGCTGGTGATGAGCATCCGGGATGGGATCCACGGACCCCTGCTGGAGCCATTTGTGCAGGCCAAGCTGCGGCCCGAGGACGGCCTGTACCTCATTCAC TGGAGCACCAGCCACCCCTACCGCCTGATCCTCACAGTGGCCCAGCGTAGCCAGGCACCAGACGGCATGCAGAGCTTGCGGCTCCGAAAGTTCCCCATTGAGCAGCAGGACGGGGCCTTC GTGCTGGAGGGCTGGGGCCGGTCCTTCCCCAGCGTTCGGGAACTTGGGGCTGCCTTGCAGGGCTGCTTGCTGAGGGCCGGGGATGACTGCTTCTCTCTGCGTCGCTGTTGCCTGCCCCAA CCAGGAGAAACCTCCAATCTCATCATCATGCGGGGGGCTCGGGCCAGCCCCAGGACACTCAACCTCAGCCAGCTCAGCTTCCACCGGGTTGACCAGAAGGAGATCACCCAGCTGTCCCAC TTGGGCCAGGGCACAAGGACCAACGTGTATGAGGGCCGCCTGCGAGTGGAGGGCAGCGGGGACCCTGAGGAGGGCAAGATGGATGACGAGGACCCCCTCGTGCCTGGCAGGGACCGTGGG CAGGAGCTACGAGTGGTGCTCAAAGTGCTGGACCCTAGTCACCATGACATCGCCCTGGCCTTCTACGAGACAGCCAGCCTCATGAGCCAGGTCTCCCACACGCACCTGGCCTTCGTGCAT GGCGTCTGTGTGCGCGGCCCTGAAAATATCATGGTGACAGAGTACGTGGAGCACGGACCCCTGGATGTGTGGCTGCGGAGGGAGCGGGGCCATGTGCCCATGGCTTGGAAGATGGTGGTG GCCCAGCAGCTGGCCAGCGCCCTCAGCTACCTGGAGAACAAGAACCTGGTTCATGGTAATGTGTGTGGCCGGAACATCCTGCTGGCCCGGCTGGGGTTGGCAGAGGGCACCAGCCCCTTC ATCAAGCTGAGTGATCCTGGCGTGGGCCTGGGCGCCCTCTCCAGGGAGGAGCGGGTGGAGAGGATCCCCTGGCTGGCCCCCGAATGCCTACCAGGTGGGGCCAACAGCCTAAGCACCGCC ATGGACAAGTGGGGGTTTGGCGCCACCCTCCTGGAGATCTGCTTTGACGGAGAGGCCCCTCTGCAGAGCCGCAGTCCCTCCGAGAAGGAGCATTTCTACCAGAGGCAGCACCGGCTGCCC GAGCCCTCCTGCCCACAGCTGGCCACACTCACCAGCCAGTGTCTGACCTATGAGCCAACCCAGAGGCCATCATTCCGCACCATCCTGCGTGACCTCACCCGGCTGCAGCCCCACAATCTT GCTGACGTCTTGACTGTGAACCCGGACTCACCGGCGTCGGACCCTACGGTTTTCCACAAGCGCTATTTGAAAAAGATCCGAGATCTGGGCGAGGGTCACTTCGGCAAGGTCAGCTTGTAC TGCTACGATCCGACCAACGACGGCACTGGCGAGATGGTGGCGGTGAAAGCCCTCAAGGCAGACTGCGGCCCCCAGCACCGCTCGGGCTGGAAGCAGGAGATTGACATTCTGCGCACGCTC TACCACGAGCACATCATCAAGTACAAGGGCTGCTGCGAGGACCAAGGCGAGAAGTCGCTGCAGCTGGTCATGGAGTACGTGCCCCTGGGCAGCCTCCGAGACTACCTGCCCCGGCACAGC ATCGGGCTGGCCCAGCTGCTGCTCTTCGCCCAGCAGATCTGCGAGGGCATGGCCTATCTGCACGCGCAGCACTACATCCACCGAGACCTAGCCGCGCGCAACGTGCTGCTGGACAACGAC AGGCTGGTCAAGATCGGGGACTTTGGCCTAGCCAAGGCCGTGCCCGAAGGCCACGAGTACTACCGCGTGCGCGAGGATGGGGACAGCCCCGTGTTCTGGTATGCCCCAGAGTGCCTGAAG GAGTATAAGTTCTACTATGCGTCAGATGTCTGGTCCTTCGGGGTGACCCTGTATGAGCTGCTGACGCACTGTGACTCCAGCCAGAGCCCCCCCACGAAATTCCTTGAGCTCATAGGCATT GCTCAGGGTCAGATGACAGTTCTGAGACTCACTGAGTTGCTGGAACGAGGGGAGAGGCTGCCACGGCCCGACAAATGTCCCTGTGAGGTCTATCATCTCATGAAGAACTGCTGGGAGACA GAGGCGTCCTTTCGCCCAACCTTCGAGAACCTCATACCCATTCTGAAGACAGTCCATGAGAAGTACCAAGGCCAGGCCCCTTCAGTGTTCAGCGTGTGCTGAGGCACAATGGCAGCCCTG CCTGGGAGGACTGGACCAGGCAGTGGCTGCAGAGGGAGCCTCCTGCTCCCTGCTCCAGGATGAAACCAAGAGGGGGATGTCAGCCTCACCCACACCGTGTGCCTTACTCCTGTCTAGAGA CCCCACCTCTGTGAACTTATTTTTCTTTCTTGGCCGTGAGCCTAACCATGATCTTGAGGGACCCAACATTTGTAGGGGCACTAATCCAGCCCTTAAATCCCCCAGCTTCCAAACTTGAGG CCCACCATCTCCACCATCTGGTAATAAACTCATGTTTTCTCTGCTGGAAAAAAAAAAAAAAA |
Protein Sequence | >7297 : length: 1187 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC |