| Gene ID | 3486 |
| Symbol | IGFBP3 |
| Synonymous | BP-53|IBP3 |
| Full name | insulin-like growth factor binding protein 3 |
| Gene description | IBP-3|IGF-binding protein 3|IGFBP-3|acid stable subunit of the 140 K IGF complex|binding protein 29|binding protein 53|growth hormone-dependent binding protein|insulin-like growth factor-binding protein 3 |
| Cytoband | 7p12.3 |
| Gene type | protein-coding |
| Synonymous | MIM:146732; HGNC:HGNC:5472; Ensembl:ENSG00000146674; HPRD:00899; Vega:OTTHUMG00000023769 |
Pathways and Diseases | Detail |
|---|---|
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | hypoxia and p53 in the cardiovascular system;PID BioCarta;100084 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Pathway | Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs);PID Reactome;500133 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Disease | overall effect;GAD |
Disease | Cancer;FunDO |
Disease | Skin disease, Genetic;FunDO |
Disease | Sickle cell disease;FunDO |
Disease | Liver disease;FunDO |
Disease | METABOLIC;GAD |
Disease | Stroke;FunDO |
Disease | Cirrhosis;FunDO |
Disease | colorectal cancer;GAD |
Disease | Hamman-Rich syndrome;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | Gestational diabetes;FunDO |
Disease | Hypothyroidism;FunDO |
Disease | Growth Disorders;GAD |
Disease | CANCER;GAD |
Disease | Endometriosis;FunDO |
Disease | Cerebral palsy;FunDO |
Disease | Growth retardation;FunDO |
Disease | breast cancer;GAD |
Disease | Fibromyalgia;FunDO |
Disease | Obesity;FunDO |
Disease | insulin-like growth factor;GAD |
Disease | Atherosclerosis;FunDO |
Disease | Acromegaly;FunDO |
Disease | Metabolic syndrome X;FunDO |
Sequence Information | |
|---|---|
Nucleotide Sequence | >3486 : length: 2638 AGATGCGAGCACTGCGGCTGGGCGCTGAGGATCAGCCGCTTCCTGCCTGGATTCCACAGCTTCGCGCCGTGTACTGTCGCCCCATCCCTGCGCGCCCAGCCTGCCAAGCAGCGTGCCCCG GTTGCAGGCGTCATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGCGGGCCGCCGGTGGCGCGGGCTGGCGCGAGCTCGGCGGGCTTGGGTCCC GTGGTGCGCTGCGAGCCGTGCGACGCGCGTGCACTGGCCCAGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAGCTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGAGC GAGGGCCAGCCGTGCGGCATCTACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAGGCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTCTGCGTCAAC GCTAGTGCCGTCAGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGTGAGCCGCCCGCGCCAGGAAATGCTAGTGAGTCGGAGGAAGACCGCAGCGCCGGCAGTGTGGAG AGCCCGTCCGTCTCCAGCACGCACCGGGTGTCTGATCCCAAGTTCCACCCCCTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCTAAAGACAGCCAGCGCTACAAAGTTGACTAC GAGTCTCAGAGCACAGATACCCAGAACTTCTCCTCCGAGTCCAAGCGGGAGACAGAATATGGTCCCTGCCGTAGAGAAATGGAAGACACACTGAATCACCTGAAGTTCCTCAATGTGCTG AGTCCCAGGGGTGTACACATTCCCAACTGTGACAAGAAGGGATTTTATAAGAAAAAGCAGTGTCGCCCTTCCAAAGGCAGGAAGCGGGGCTTCTGCTGGTGTGTGGATAAGTATGGGCAG CCTCTCCCAGGCTACACCACCAAGGGGAAGGAGGACGTGCACTGCTACAGCATGCAGAGCAAGTAGACGCCTGCCGCAAGGTTAATGTGGAGCTCAAATATGCCTTATTTTGCACAAAAG ACTGCCAAGGACATGACCAGCAGCTGGCTACAGCCTCGATTTATATTTCTGTTTGTGGTGAACTGATTTTTTTTAAACCAAAGTTTAGAAAGAGGTTTTTGAAATGCCTATGGTTTCTTT GAATGGTAAACTTGAGCATCTTTTCACTTTCCAGTAGTCAGCAAAGAGCAGTTTGAATTTTCTTGTCGCTTCCTATCAAAATATTCAGAGACTCGAGCACAGCACCCAGACTTCATGCGC CCGTGGAATGCTCACCACATGTTGGTCGAAGCGGCCGACCACTGACTTTGTGACTTAGGCGGCTGTGTTGCCTATGTAGAGAACACGCTTCACCCCCACTCCCCGTACAGTGCGCACAGG CTTTATCGAGAATAGGAAAACCTTTAAACCCCGGTCATCCGGACATCCCAACGCATGCTCCTGGAGCTCACAGCCTTCTGTGGTGTCATTTCTGAAACAAGGGCGTGGATCCCTCAACCA AGAAGAATGTTTATGTCTTCAAGTGACCTGTACTGCTTGGGGACTATTGGAGAAAATAAGGTGGAGTCCTACTTGTTTAAAAAATATGTATCTAAGAATGTTCTAGGGCACTCTGGGAAC CTATAAAGGCAGGTATTTCGGGCCCTCCTCTTCAGGAATCTTCCTGAAGACATGGCCCAGTCGAAGGCCCAGGATGGCTTTTGCTGCGGCCCCGTGGGGTAGGAGGGACAGAGAGACAGG GAGAGTCAGCCTCCACATTCAGAGGCATCACAAGTAATGGCACAATTCTTCGGATGACTGCAGAAAATAGTGTTTTGTAGTTCAACAACTCAAGACGAAGCTTATTTCTGAGGATAAGCT CTTTAAAGGCAAAGCTTTATTTTCATCTCTCATCTTTTGTCCTCCTTAGCACAATGTAAAAAAGAATAGTAATATCAGAACAGGAAGGAGGAATGGCTTGCTGGGGAGCCCATCCAGGAC ACTGGGAGCACATAGAGATTCACCCATGTTTGTTGAACTTAGAGTCATTCTCATGCTTTTCTTTATAATTCACACATATATGCAGAGAAGATATGTTCTTGTTAACATTGTATACAACAT AGCCCCAAATATAGTAAGATCTATACTAGATAATCCTAGATGAAATGTTAGAGATGCTATATGATACAACTGTGGCCATGACTGAGGAAAGGAGCTCACGCCCAGAGACTGGGCTGCTCT CCCGGAGGCCAAACCCAAGAAGGTCTGGCAAAGTCAGGCTCAGGGAGACTCTGCCCTGCTGCAGACCTCGGTGTGGACACACGCTGCATAGAGCTCTCCTTGAAAACAGAGGGGTCTCAA GACATTCTGCCTACCTATTAGCTTTTCTTTATTTTTTTAACTTTTTGGGGGGAAAAGTATTTTTGAGAAGTTTGTCTTGCAATGTATTTATAAATAGTAAATAAAGTTTTTACCATTAAA AAAATATCTTTCCCTTTGTTATTGACCATCTCTGGGCTTTGTATCACTAATTATTTTATTTTATTATATAATAATTATTTTATTATAATAAAATCCTGAAAGGGGAAAATAAAAAAAA |
Protein Sequence | >3486 : length: 297 MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAV SRLRAYLLPAPPAPGEPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRG VHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK |