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Cancer metastasis database

Annotation category 5

Gene information

Gene ID 1111
Symbol

CHEK1

Synonymous

CHK1

Full name

checkpoint kinase 1

Gene description

CHK1 checkpoint homolog|Checkpoint, S. pombe, homolog of, 1|Chk1-S|cell cycle checkpoint kinase|checkpoint kinase-1|serine/threonine-protein kinase Chk1

Cytoband

11q24.2

Gene type

protein-coding

Synonymous

MIM:603078; HGNC:HGNC:1925; Ensembl:ENSG00000149554; HPRD:04356; Vega:OTTHUMG00000165853

Pathway and disease

Pathways and Diseases

Detail

Pathway

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;PID Reactome;500938

Pathway

cell cycle: g2/m checkpoint;PID BioCarta;100159

Pathway

Activation of ATR in response to replication stress;PID Reactome;500319

Pathway

Circadian rhythm pathway;PID Curated;200068

Pathway

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;PID Reactome;500318

Pathway

Cell Cycle Checkpoints;Reactome;REACT:1538

Pathway

role of brca1 brca2 and atr in cancer susceptibility;PID BioCarta;100234

Pathway

G2/M DNA damage checkpoint;PID Reactome;500952

Pathway

regulation of cell cycle progression by plk3;PID BioCarta;100068

Pathway

cdc25 and chk1 regulatory pathway in response to dna damage;PID BioCarta;100212

Pathway

p53 signaling pathway;KEGG PATHWAY;hsa04115

Pathway

Cell cycle;KEGG PATHWAY;hsa04110

Pathway

atm signaling pathway;PID BioCarta;100235

Pathway

rb tumor suppressor/checkpoint signaling in response to dna damage;PID BioCarta;100046

Pathway

G2/M Checkpoints;PID Reactome;500874

Pathway

p53 pathway;PID Curated;200175

Disease

CANCER;GAD

Disease

Cancer;FunDO

Disease

Fanconi's anemia;FunDO

Disease

colorectal cancer;GAD

Sequence Information

Nucleotide Sequence

>1111 : length: 4174
CTTTTAAATTTGCGTTGTAAGATTTATTTTGGCTCTCCCCGCCTGTTCTTTGCACATTAAAAATGAAAAAGTTTGTAGAACTAAGCTAAGCAGATGGTCTTCCTGCAAAAAGACCGGGCT
GAAGTAAAGCATTGTTTTGGAGCTGGTTCACAGAAAAAAGGCAAAACTGGTTATCCTGACTTCAAGCTCCAACATAAACTGCTCGCTTTCTCCGGGAAACTTGCCCCGCCACACACACTT
GACTGCGTGGCCAGTTCTTTCGAAGCCTCTCGCTCCCAACACGGAGTTCCTCCCATTTCTTCACAGTCGGCTCTCAGCAGCTGCTGCTGGTTTCTCGGCTCCAGCACCACGAGTACCGCA
CTCTGAGGTTTACAAAGCACTCTGCTTCACCGACTGTGATCCTCACAGTCCTGTCCGGTGGCCTCACGCAGGTGGCGGTGCAGCCTTTCAGGCCCAGAGCGGCCAGGAGCGAAGCCCGCA
GCCCCGCCTGGAAGCGCAGCGCGGTCGGTCGCGCGCCCCTGAGGCTTGGAGGCCTGGGCTTCCCCCAGCAGCGCTCGAGCACCGCCCAGTCGAGCCTCACACCGGATGCCACTTCATATT
TGGGCCCAGAGCTCAATTCGCGCCGATGCGGTCCGCCGTCCTTAAATCTCTTCAGCCAGGATCTCTCCCCGACTGCAAAGCAGCCCTGGGCGGGAGCGGCAACATCTCCACGTCACCCTT
TTGGAGCCGCCGACATTCAGAGGGGCAGGACACGGGAACGCGCGCTGTCTTGCTTTACGGCGCGGGTGCGCGAGTTTGCGGCAGCGTGACGCCCTCAAGTTTTGGCGGGAAAAGCGCTGC
ATTTGGATTCCTGCAGTGGTGGGCAAAGGACAGTCCGCCGAGGTGCTCGGTGGAGTCATGGCAGTGCCCTTTGTGGAAGACTGGGACTTGGTGCAAACCCTGGGAGAAGGTGCCTATGGA
GAAGTTCAACTTGCTGTGAATAGAGTAACTGAAGAAGCAGTCGCAGTGAAGATTGTAGATATGAAGCGTGCCGTAGACTGTCCAGAAAATATTAAGAAAGAGATCTGTATCAATAAAATG
CTAAATCATGAAAATGTAGTAAAATTCTATGGTCACAGGAGAGAAGGCAATATCCAATATTTATTTCTGGAGTACTGTAGTGGAGGAGAGCTTTTTGACAGAATAGAGCCAGACATAGGC
ATGCCTGAACCAGATGCTCAGAGATTCTTCCATCAACTCATGGCAGGGGTGGTTTATCTGCATGGTATTGGAATAACTCACAGGGATATTAAACCAGAAAATCTTCTGTTGGATGAAAGG
GATAACCTCAAAATCTCAGACTTTGGCTTGGCAACAGTATTTCGGTATAATAATCGTGAGCGTTTGTTGAACAAGATGTGTGGTACTTTACCATATGTTGCTCCAGAACTTCTGAAGAGA
AGAGAATTTCATGCAGAACCAGTTGATGTTTGGTCCTGTGGAATAGTACTTACTGCAATGCTCGCTGGAGAATTGCCATGGGACCAACCCAGTGACAGCTGTCAGGAGTATTCTGACTGG
AAAGAAAAAAAAACATACCTCAACCCTTGGAAAAAAATCGATTCTGCTCCTCTAGCTCTGCTGCATAAAATCTTAGTTGAGAATCCATCAGCAAGAATTACCATTCCAGACATCAAAAAA
GATAGATGGTACAACAAACCCCTCAAGAAAGGGGCAAAAAGGCCCCGAGTCACTTCAGGTGGTGTGTCAGAGTCTCCCAGTGGATTTTCTAAGCACATTCAATCCAATTTGGACTTCTCT
CCAGTAAACAGTGCTTCTAGTGAAGAAAATGTGAAGTACTCCAGTTCTCAGCCAGAACCCCGCACAGGTCTTTCCTTATGGGATACCAGCCCCTCATACATTGATAAATTGGTACAAGGG
ATCAGCTTTTCCCAGCCCACATGTCCTGATCATATGCTTTTGAATAGTCAGTTACTTGGCACCCCAGGATCCTCACAGAACCCCTGGCAGCGGTTGGTCAAAAGAATGACACGATTCTTT
ACCAAATTGGATGCAGACAAATCTTATCAATGCCTGAAAGAGACTTGTGAGAAGTTGGGCTATCAATGGAAGAAAAGTTGTATGAATCAGGTTACTATATCAACAACTGATAGGAGAAAC
AATAAACTCATTTTCAAAGTGAATTTGTTAGAAATGGATGATAAAATATTGGTTGACTTCCGGCTTTCTAAGGGTGATGGATTGGAGTTCAAGAGACACTTCCTGAAGATTAAAGGGAAG
CTGATTGATATTGTGAGCAGCCAGAAGATTTGGCTTCCTGCCACATGATCGGACCATCGGCTCTGGGGAATCCTGGTGAATATAGTGCTGCTATGTTGACATTATTCTTCCTAGAGAAGA
TTATCCTGTCCTGCAAACTGCAAATAGTAGTTCCTGAAGTGTTCACTTCCCTGTTTATCCAAACATCTTCCAATTTATTTTGTTTGTTCGGCATACAAATAATACCTATATCTTAATTGT
AAGCAAAACTTTGGGGAAAGGATGAATAGAATTCATTTGATTATTTCTTCATGTGTGTTTAGTATCTGAATTTGAAACTCATCTGGTGGAAACCAAGTTTCAGGGGACATGAGTTTTCCA
GCTTTTATACACACGTATCTCATTTTTATCAAAACATTTTGTTTAATTCAAAAAGTACATATTCCATGTTGATTTAATTCTAAGATGAACCAATAAAGACATAATTCTTGTGACTTTTGG
ACAGTAGATTTATCAGTCTGTGAAGCGAAGCCAGCTTCAAAACATATCCCCAAGATTTGTACTTATATTTTCAAAAGGGCCTGGCCAGTTATATAAACCTGTTTTTGAATTATAATGATT
AATTAAAATTGCAAGTAGGTGTTTTTTCCAGTGTAGTTAGTAAAATACTTGTATTTTACAGTGTTGCATAAACTCTAGTGCTTAACTAACTTTACTCTAAAAATTACTGTTGAACATCTT
AAATATTTTTCTATATTTTCTACTTTCATAGCCATATTTTAACCTTTTCAACTTACTGGTGACCAAGCTTTTAGGTGATAAAGAATAAAAGAGGGAAGGGAAGAGTAAGGAAGCTATAAG
AAAAATAGATCTGATTCTTTGTTCCTTTACCTGTTAGACTTACAAAAAGTTTGTTTTTCTAATAAAATTTGTATCAACTTTGGGGCATATTAGGTTGAGGCCTTGGCTCCTGCCTGTAGT
CCCAGCTACTTAGGAGGCTGAGAGAGGAGGATCGCGTGAACCTGGAAGTTTGAGGCTGTAGTGAGCTATGATTGCACCAGTGCACTCCAGCTTGGATGACAGAGTAAGACCCTACCTCTA
ATAAAAATTTTTAAAATTGTAAAACATTATAAAATTAATCAGTTATTTTAATCTGAAGCCAAGAACATGTAGAATGTTATGATTAGAGTTTATCACATATTAATGTATACTGGCAAATTG
TGTTACTGGAGTATACCCATAGGAGGAATAAATTCAAACCTGTTTTATTTATTTGAACCTATTTACGGTATGCTTAAGAATTGAATCAGTATAAATTCTCAAATATGGGAGAAATTTTGT
TCTTGAGAATTATCTGAGTCATTAATATTTTTCAAAAACAGCTCTCACTGACTTGAACCTCTTCTGTAAGCTCTAACCTTTTACCTGCTTTACATTTCCACTTGAATGTCTAGTAGGCAT
CTCTTGACCAAAAACAGCTTTTGATTCCTGTTCTCCAACCTGTTCCTCTCCTAGTTTTCTCCATCTCAGAAATGTTACTTCCTCTGCAAAGTCTTTCCCTGACTTATCTAAAATAATAAC
CTCCTCTGTTTGCTGTGGGAATTTGTATAGAATGGTGGGAAAATTTCAAGTTTCATATTTGGATTAGCTCTGACATTTATTTATCTGAACACTGGTAATTGCCTCAGTAAAGACACTGAT
AATAAGTACCTTTTAGAGTTATTTTAATCTTTAATGCTTTAATGTGTAGGAAGAGTATAGTGTCCTGTTTTGCACAGAAAGGCATTCTGTAAATAATAAGTTGCCTTAATTTTCCTGTAA
TGTTCATTATATTGTTGTGGGAAGGTATTTACTCCTATTATTAAAAATAAAAATGTGTAAAATTTACTACCTGAAAAAAAAAAAAAAAAAAAAA

Protein Sequence

>1111 : length: 492
MRSAVLKSLQPGSLPDCKAALGGSGNISTSPFWSRRHSEGQDTGTRAVLLYGAGARVCGSVTPSSFGGKSAAFGFLQWWAKDSPPRCSVESWQCPLWKTGTWCKPWEKVPMEKPDIGMPE
PDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEK
KTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISF
SQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLID
IVSSQKIWLPAT