| Chk1(h) + ATP --ATR(h)--> Chk1(h){p} + ADP (phosphorylation)
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Cdc25A(h) + Chk1(h) <==> Cdc25A(h):Chk1(h) (binding)
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Cdc25B(h) + Chk1(h) <==> Cdc25B(h):Chk1(h) (binding)
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Cdc25C(h) + Chk1(h) <==> Cdc25C(h):Chk1(h) (binding)
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brca1(h) + Chk1(h) <==> brca1(h):Chk1(h) (binding)
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Chk1(h) + p73alpha(h) <==> Chk1(h):p73alpha(h) (binding)
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Chk1(h) + p73beta(h) <==> Chk1(h):p73beta(h) (binding)
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Wip1(h) + Chk1(h) <==> Wip1(h):Chk1(h) (binding)
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BLM(h) + Chk1(h) <==> BLM(h):Chk1(h) (binding)
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Chk1(h) + ATP --> Chk1(h){pS317} + ADP (phosphorylation)
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Chk1(h) + ATP --> Chk1(h){pS345} + ADP (phosphorylation)
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Chk1(h) + ATP --ATR(h)--> Chk1(h){pS345} + ADP (phosphorylation)
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Chk1(h) + Claspin(h){p}n <==> Chk1(h):Claspin(h){p}n (binding)
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Chk1(h) + ATP --> Chk1(h){p} + ADP (phosphorylation)
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Chk1(h) --/ Cdc25A(h) (inhibition; decrease of abundance)
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Cdc25C(h):Chk1(h) + ATP --> Cdc25C(h){pS216} + Chk1(h) + ADP (phosphorylation; dissociation)
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Cdc25B(h):Chk1(h) + ATP --> Cdc25B(h){p} + Chk1(h) + ADP (phosphorylation; dissociation)
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Cdc25A(h):Chk1(h) + ATP --> Cdc25A(h){p} + Chk1(h) + ADP (phosphorylation; dissociation)
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CHEK1(h) --> Chk1(h) (expression).
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Chk1(h){pS345} --Wip1(h)--> p + Chk1(h) (dephosphorylation)
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Chk1(h){pS345} --> Chk1(h) + p (dephosphorylation)
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HAUSP(h) --> Chk1(h) (activation)
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Cdc25(h) + ATP --Chk1(h)--> Cdc25(h){p} + ADP (phosphorylation)
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p53(h) + ATP --Chk1(h)--> p53(h){pS15} + ADP (phosphorylation)
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p53(h) + ATP --Chk1(h)--> p53(h){pS20} + ADP (phosphorylation)
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p53(h) + ATP --Chk1(h)--> p53(h){pS37} + ADP (phosphorylation)
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Cdc25B3(h) + ATP --Chk1(h)--> Cdc25B3(h){p} + ADP (phosphorylation)
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p73alpha(h) + ATP --Chk1(h)--> p73alpha(h){pS47} + ADP (phosphorylation)
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BLM(h) + ATP --Chk1(h)--> BLM(h){pS} + ADP (phosphorylation)
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Mdm4(h) + ATP --Chk1(h)--> Mdm4(h){pS367} + ADP (phosphorylation)
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Cdc25C(m.s.) + ATP --Chk1(h)--> Cdc25C(m.s.){pS216} + ADP (phosphorylation)
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Chk1(h) + 2 ATP --ATM(m.s.)--> Chk1(h){pS317}{pS345} + 2 ADP (phosphorylation)
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Chk1(h) + 2 ATP --ATR(m.s.)--> Chk1(h){pS317}{pS345} + 2 ADP (phosphorylation)
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Chk1(h) + 2 ATP --DNA-PK(m.s.)--> Chk1(h){pS317}{pS345} + 2 ADP (phosphorylation)
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Chk1(h) --> Cdc25A(h){ub(n)} (increase of ubiquitination)
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CHEK1(h) --> Chk1(h) (expression).
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Chk1(h){pS345} --Wip1(m.s.)--> Chk1(h) + p (dephosphorylation)
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Aurora-B(h) + ATP --Chk1(h)--> Aurora-B(h){p} + ADP (phosphorylation)
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Cdc25C(h) + ATP --Chk1(h)--> Cdc25C(h){p} + ADP (phosphorylation)
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Cdc25C-isoform1(h) + ATP --Chk1(h)--> Cdc25C-isoform1(h){pS216} + ADP (phosphorylation)
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Cdc25A(h) + ATP --Chk1(h)--> Cdc25A(h){pS76} + ADP (phosphorylation)
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