| General information | Literature | Expression | Regulation | Mutation | Interaction |
Basic Information | |
|---|---|
Gene ID | 912 |
Name | CD1D |
Synonymous | CD1A|R3;CD1d molecule;CD1D;CD1d molecule |
Definition | CD1D antigen, d polypeptide|HMC class I antigen-like glycoprotein CD1D|R3G1|T-cell surface glycoprotein CD1d|antigen-presenting glycoprotein CD1d|differentiation antigen CD1-alpha-3|thymocyte antigen CD1D |
Position | 1q22-q23 |
Gene type | protein-coding |
Cancer type | Abstract |
| acute lymphoblastic leukemia;Hematological | CTLA-4 is a key factor in regulating and maintaining self tolerance, providing anegative signal to the T cell and thus limiting immune responses. Several polymorphisms within the CTLA-4 gene have been associated with an increased riskof developing autoimmune diseases and, very recently, with susceptibility to human cancer. Acute lymphoblastic leukemia is a clonal disorder of lymphoid progenitors representing the most frequent malignancy of childhood. Here, we show the presence at significantly elevated levels of a circulating soluble form of CTLA-4 in 70% of B-ALL pediatric patients with active disease, the positive correlation between the percentage of leukemic B lymphocytes and the amount of serum sCTLA-4, and the expression of sCTLA-4 transcript by B cells in patients. Finally, a correlation between CD1d expression (a negative prognostic marker) and the sCTLA-4 in B-ALL patients was observed. This suggests a possible role of this soluble molecule as a marker of progression or severity of the neoplastic disease. |