| General information | Literature | Expression | Regulation | Mutation | Interaction |
Basic Information | |
|---|---|
Gene ID | 892 |
Name | CCNC |
Synonymous | CycC;cyclin C;CCNC;cyclin C |
Definition | SRB11 homolog|cyclin-C|hSRB11 |
Position | 6q21 |
Gene type | protein-coding |
Cancer type | Abstract |
| acute lymphoblastic leukemia;Hematological | OBJECTIVE: To explore the relationship between human cyclin C (CCNC) gene and childhood acute lymphocytic leukemia (ALL). METHODS: The total RNA isolated frommyeloid tissues of normal children and of children with newly diagnosed ALL and from ALL cell line 6T-CEM was reversely transcribed into cDNA. Real-time fluorescence quantitative PCR method was used to detect CCNC gene expression. RESULTS: CCNC was expressed in myeloid tissues of normal children and of children with newly diagnosed ALL as well as 6T-CEM. The relative expression level of CCNC gene in children with newly diagnosed ALL was significantly lower than in normalcontrols (2.35 +/- 0.83 vs 13.5 +/- 0.30; P <0.05). CONCLUSIONS: CCNC gene showslower expression in children with newly diagnosed ALL, suggesting that it may bea tumor suppressing gene in childhood ALL. |