| General information | Literature | Expression | Regulation | Mutation | Interaction |
Basic Information | |
|---|---|
Gene ID | 64109 |
Name | CRLF2 |
Synonymous | CRL2|CRLF2Y|TSLPR;cytokine receptor-like factor 2;CRLF2;cytokine receptor-like factor 2 |
Definition | IL-XR|P2RY8/CRLF2 fusion|TSLP receptor|cytokine receptor CRL2 precusor|cytokine receptor-like 2|thymic stromal lymphopoietin protein receptor|thymic stromal lymphopoietin receptor|thymic stromal-derived lymphopoietin receptor |
Position | Xp22.3; Yp11.3 |
Gene type | protein-coding |
Cancer type | Abstract |
| acute lymphoblastic leukemia;Hematological | BACKGROUND: Genome-wide analysis studies have demonstrated that IKZF1, CRLF2, and JAK2 gene alterations correlate with poor prognosis in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). However, the prognostic significance forthese gene alterations has not been clarified in Japanese patients. PROCEDURE: Atotal of 194 patients with BCP-ALL enrolled in the Japanese children's cancer & Leukemia Study Group ALL 2004 clinical trial were assessed for the presence of three different gene alterations: IKZF1 deletions, CRLF2 expression and JAK2 mutation. RESULTS: IKZF1 deletions and CRLF2-high expression were identified in 22 of 177 (12%) patients and in 15 of 141 (11%) patients, respectively. However,JAK2 R683 mutation was detected only one of 177 patients. The 4-year event-free survival (4y-EFS) was different when comparing patients with or without IKZF1 deletions (68.2% vs. 85.2%; P = 0.04) and was also different when comparing patients with different CRLF2 expression levels (high, 66.7% vs. low, 88.1%; P =0.03). The differences in 4y-EFS were statistically significant in patients withALL in the National cancer Institute (NCI)-high risk group (HR-ALL) (IKZF1 deletions: yes, 58.3% vs. no, 87.0%, P = 0.02; CRLF2 expression: high, 55.6% vs.low, 85.3%, P = 0.04) but not in patients with ALL in the NCI-standard risk group (SR-ALL; IKZF1 deletions: yes, 80.0% vs. no, 84.4%, P = 0.75; CRLF2 expression: high, 83.3% vs. low, 89.2%, P = 0.77). Coexistence of IKZF1 deletions and CRLF2-high expression associated with poor outcomes. CONCLUSIONS: IKZF1 deletions and CRLF2-high expression predicted poor outcomes in patients with HR-ALL but not in patients with SR-ALL in our Japanese cohort. Pediatr Blood cancer 2013;60:1587-1592. (c) 2013 Wiley Periodicals, Inc.#CI- Copyright (c) 2013 Wiley Periodicals, Inc. |