| General information | Literature | Expression | Regulation | Mutation | Interaction |
Basic Information | |
|---|---|
Gene ID | 57379 |
Name | AICDA |
Synonymous | AID|ARP2|CDA2|HIGM2;activation-induced cytidine deaminase;AICDA;activation-induced cytidine deaminase |
Definition | cytidine aminohydrolase|integrated into Burkitt's lymphoma cell line Ramos |
Position | 12p13 |
Gene type | protein-coding |
Cancer type | Abstract |
| brain Tumors;Neurological | We conducted a hospital-based case-control study in Korea to investigate whetherapoptosis- and cell cycle control-related genes are associated with childhood brain tumor. Incident brain tumor cases (N = 70) and non-cancer controls (N = 140), frequency-matched by age and gender, were selected from 3 teaching hospitals in Seoul between 2003 and 2006. Tag single nucleotide polymorphisms (SNPs) (N = 297) in 30 genes related to apoptosis and cell cycle control were selected using a pairwise linkage-disequilibrium-based algorithm. Five tag SNPs in 2 genes (AICDA and CASP14) remained significant after adjusted multiple tests. The most significant association with childhood brain tumor risk was for IVS1-401G>C in the AICDA gene [odds ratio (OR) = 2.8; 95% confidence interval (95%CI) = 1.25-6.46]; the polymorphism *9276A>C of CASP14 was associated with decreased brain tumor risk (OR = 0.4; 95%CI = 0.19-0.95). We concluded that genetic polymorphisms in AICDA and CASP14 are associated with risk for brain tumor in Korean children. |