| General information | Literature | Expression | Regulation | Mutation | Interaction |
Basic Information | |
|---|---|
Gene ID | 4830 |
Name | NME1 |
Synonymous | AWD|GAAD|NB|NBS|NDKA|NDPK-A|NDPKA|NM23|NM23-H1;non-metastatic cells 1, protein (NM23A) expressed in;NME1;non-metastatic cells 1, protein (NM23A) expressed in |
Definition | NDP kinase A|granzyme A-activated DNase|metastasis inhibition factor nm23|nucleoside diphosphate kinase A|tumor metastatic process-associated protein |
Position | 17q21.3 |
Gene type | protein-coding |
Cancer type | Abstract |
| thyroid Tumors ;Endocrine | childhood thyroid cancer is known to be aggressive. High incidence of lymph nodeand distant metastasis are characteristic features of these cases. In adult, reduced expression of nm23-H1/nucleoside diphosphate (NDP) kinase has been correlated with cancer invasion and metastasis in some tumor types. Therefore, we examined the expression of nm23-H1 gene product in childhood thyroid carcinomas in Japan. 27 primary thyroid carcinomas and 8 metastatic lymph nodes were analyzed by immunohistochemistry using monoclonal antibody H1-229. 21 out of 23 cases (91%) of papillary carcinomas were positively immunostained, whereas none of the 4 follicular carcinomas showed any immunoreactivity. No correlation was found between the nm23-H1/NDP kinase antigen expression and nodal involvement ordistant metastasis in primary tumors. However, only 50% (4 out of 8) of metastatic lymph nodes from papillary carcinoma were positively stained, demonstrating a significant decrease comparing to those of primary sites. These data indicate that the expression of nm23-H1/NDP kinase cannot predict tumor metastatic potential in childhood thyroid cancer. |