| General information | Literature | Expression | Regulation | Mutation | Interaction |
Basic Information | |
|---|---|
Gene ID | 29850 |
Name | TRPM5 |
Synonymous | LTRPC5|MTR1;transient receptor potential cation channel, subfamily M, member 5;TRPM5;transient receptor potential cation channel, subfamily M, member 5 |
Definition | LTrpC-5|MLSN1 and TRP-related|MLSN1- and TRP-related gene 1 protein|long transient receptor potential channel 5|transient receptor potential cation channel subfamily M member 5 |
Position | 11p15.5 |
Gene type | protein-coding |
Cancer type | Abstract |
| leukemia;Hematological | Transient receptor potential (TRP) channels are important candidates mediating Ca2+ influx in excitable and nonexcitable cells such as normal and neoplastic hematopoietic tissues. They are non selective cation channels implicated in Ca2+signaling in hematologic tumor cells. Here, we review the growing experimental evidence indicating that TRP channels should be included among the genes whose expression is altered in hematologic malignancies such as leukemias (AML, ALL, CML and CML), B- and T-lymphomas and multiple myelomas (MM). These effects depend on the widespread roles played by the TRP channels in the modulation of the proliferation, differentiation and apoptosis of the haematopoietic cells. The analysis of the expression of the different TRP channels belonging to the TRPMs,TRPVs, TRPCs, TRPPs channel families expressed in different haematological malignacies, evidenced a widespread expression of TRPV2 channel in the myeloid and lymphoid leukemias, and a very peculiar expression of this channel in different types of B cell lymphomas and multiple myeloma, that paralleles the restricted expression of TRPV2 in normal immune cells respect to its presence inother human tissues. In vivo studies in childhood AML and ALL patients also evidenced the presence of a genetic polymorphism of the TRPM5 gene, that reducedthe risk to develop leukaemia in the childhood's population. Finally, of interest, the coexpression of TRPV5 and TRPV6 channels in lymphocytes, and theirinvolved in the radioresistance of K562 erythroleukaemia cells to ionizing radiation exposure. Thus in conclusion, the TRP channels represent a promising targets for hematologic cancer therapy, and their exploitation may open to a novel pharmaceutical and clinical approaches. |