| General information | Literature | Expression | Regulation | Mutation | Interaction |
Basic Information | |
|---|---|
Gene ID | 22877 |
Name | MLXIP |
Synonymous | MIR|MONDOA|bHLHe36;MLX interacting protein;MLXIP;MLX interacting protein |
Definition | MLX-interacting protein|Mlx interactor|MondoA|class E basic helix-loop-helix protein 36|transcriptional activator MondoA |
Position | 12q24.31 |
Gene type | protein-coding |
Cancer type | Abstract |
| acute lymphoblastic leukemia;Hematological | Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted therapy, we performed a comprehensive transcriptome analysis identifying MondoA (MLXIP) - a transcription factor regulating glycolysis - to be overexpressed in ALL compared to normal tissues. Using microarray-profiling, gene-set enrichment analysis, RNA interference and functional assays we show that MondoA overexpression increases glucose catabolism and maintains a more immature phenotype, which is associated with enhanced survival and clonogenicity of leukemia cells. These data point to an important contribution of MondoA to leukemia aggressiveness and make MondoA a potential candidate for targeted treatment of ALL.#CI- Copyright (c) 2012 Elsevier Ltd. ALL rights reserved. |