| General information | Literature | Expression | Regulation | Mutation | Interaction |
Basic Information | |
|---|---|
Gene ID | 2191 |
Name | FAP |
Synonymous | DPPIV|FAPA;fibroblast activation protein, alpha;FAP;fibroblast activation protein, alpha |
Definition | 170 kDa melanoma membrane-bound gelatinase|integral membrane serine protease|seprase |
Position | 2q23 |
Gene type | protein-coding |
Cancer type | Abstract |
| Hepatoblastoma;Gastrointestinal | Infantile and childhood hepatoblastoma occurs more frequently in persons heterozygous for the familial adenomatous polyposis (FAP) gene than in the general population. This observation is based on numerous case reports plus the results of an international survey of FAP registries. However, the frequency of this rare tumor in FAP patients is unknown. In a retrospective review of our family history data, 2/470 (0.42%) children born to 241 patients with FAP had hepatoblastoma. This figure is significantly higher than the 1/100,000 incidenceof hepatoblastoma in the general population. However, for genetic counseling purposes, an empiric risk of less than 1% for hepatoblastoma can be cited to persons with FAP for their children. |