Entrez Gene

Basic Information
Gene ID	995
Name	CDC25C
Synonymous	CDC25\|PPP1R60;cell division cycle 25 homolog C (S. pombe);CDC25C;cell division cycle 25 homolog C (S. pombe)
Definition	M-phase inducer phosphatase 3\|cell division cycle 25C\|dual specificity phosphatase CDC25C\|mitosis inducer CDC25\|phosphotyrosine phosphatase\|protein phosphatase 1, regulatory subunit 60
Position	5q31
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
cyclinD1(h) + Cdc25C(h) <==> cyclinD1(h):Cdc25C(h) (binding)
cyclinB(h) + Cdc25C(h) <==> cyclinB(h):Cdc25C(h) (binding)
Cdc25C(h) + p38alpha(h) <==> Cdc25C(h):p38alpha(h) (binding)
Cdc25C(h) + Chk1(h) <==> Cdc25C(h):Chk1(h) (binding)
Cdc25C(h) + ATP --cyclinB(h):Cdk1(h)--> Cdc25C(h){p} + ADP (phosphorylation)
Cdc25C(h) + ATP --CaMKII(r){p}--> Cdc25C(h){p} + ADP (phosphorylation)
Cdc25C(h) + ATP --Chk2(h){pT68}--> Cdc25C(h){p} + ADP (phosphorylation)
Cdc25C(h) + ATP --Chk2(h)--> Cdc25C(h){pS216} + ADP (phosphorylation)
Cdc25C(h) + ATP --plk1(h)--> Cdc25C(h){pS198} + ADP (phosphorylation)
Cdc25C(h) + ATP --> Cdc25C(h){pS216} + ADP (phosphorylation)
Cdc25C(h) + ATP --Chk1(h)--> Cdc25C(h){p} + ADP (phosphorylation)
Pin1(h):Cdc25C(h){p} --PP2A(pg)--> Pin1(h) + Cdc25C(h) + p (dephosphorylation; dissociation)
cdc25C(h) --> Cdc25C(h) (expression).
cyclinB1(h):Cdk1(h){pY15} --Cdc25C(h)--> cyclinB1(h):Cdk1(h) + p (dephosphorylation)
Cdc25C-isoform1(h) + ATP --Chk1(h)--> Cdc25C-isoform1(h){pS216} + ADP (phosphorylation)
Cdc25C-isoform1(h) + ATP --Chk2(h)--> Cdc25C-isoform1(h){pS216} + ADP (phosphorylation)
cdc25C(h) --> Cdc25C-isoform1(h) (expression).
cdc25C(h) --> Cdc25C-isoform2(h) (expression).
cdc25C(h) --> Cdc25C-isoform4(h) (expression).
cdc25C(h) --> Cdc25C-isoform5(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
168	Phosphoserine.		Swiss-Prot 53.0
216	Phosphoserine (by CHK1, CHK2 and BRSK1).		Swiss-Prot 53.0
122	Phosphoserine (CDK1)	8119945	Phospho.ELM 6.0
130	Phosphothreonine (CDK1)	8119945	Phospho.ELM 6.0
48	Phosphothreonine (CDK1)	8119945	Phospho.ELM 6.0
67	Phosphothreonine (CDK1)	8119945	Phospho.ELM 6.0
214	Phosphoserine (CDK1)	8119945;12766774	Phospho.ELM 6.0
191	Phosphoserine (PLK3)	14968113	Phospho.ELM 6.0
216	Phosphoserine (CHK2;BRSK1)	10744722;15629715;9836640;9543386	Phospho.ELM 6.0
198	Phosphoserine (PLK1;PLK3)	11897663;14968113	Phospho.ELM 6.0
168	Phosphoserine (CDK1;MAPK9)	8119945;12742231	Phospho.ELM 6.0

Transcription Factors [Top]