Entrez Gene

Basic Information
Gene ID	9759
Name	HDAC4
Synonymous	AHO3\|BDMR\|HA6116\|HD4\|HDAC-4\|HDAC-A\|HDACA;histone deacetylase 4;HDAC4;histone deacetylase 4
Definition	histone deacetylase A
Position	2q37.3
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
HDAC4(h) --Caspase-2(h)--> HDAC4-p97(h) + HDAC4-p34(h) (processing)
HDAC4(h) --Caspase-3(h)--> HDAC4-p97(h) + protein remnants (processing)
HDAC4(h) + 2 ATP --> HDAC4(h){pS}{pY} + 2 ADP (phosphorylation)
ERK1(v.s.) + HDAC4(h) <==> ERK1(v.s.):HDAC4(h) (binding)
ERK2(v.s.) + HDAC4(h) <==> ERK2(v.s.):HDAC4(h) (binding)
HDAC4(h) + ATP --ERK2(h)--> HDAC4(h){p} + ADP (phosphorylation)
HDAC4(h) + cyclinD1(h) <==> HDAC4(h):cyclinD1(h) (binding)
HDAC4(h) + ER-alpha-L(h) <==> HDAC4(h):ER-alpha-L(h) (binding)
NCOR1(h) + HDAC4(h) <==> NCOR1(h):HDAC4(h) (binding)
SMRT(h) + HDAC4(h) <==> SMRT(h):HDAC4(h) (binding)
HDAC4(h) + HDAC3(h) <==> HDAC4(h):HDAC3(h) (binding)
NCOR1-isoform1(m) + HDAC4(h) <==> NCOR1-isoform1(m):HDAC4(h) (binding)
NCOR1(h) + HDAC3(h) + HDAC4(h) <==> NCOR1(h):HDAC3(h):HDAC4(h) (binding)
SMRT(h) + HDAC3(h) + HDAC4(h) <==> SMRT(h):HDAC3(h):HDAC4(h) (binding)
14-3-3sigma(m.s.) + HDAC4(h) <==> 14-3-3sigma(m.s.):HDAC4(h) (binding)
HDAC4(h) --> HDAC4(h) (expression).
MEF2C(m) + HDAC4(h) <==> MEF2C(m):HDAC4(h) (binding)
TIS7(r) + HDAC4(h) <==> TIS7(r):HDAC4(h) (binding)
HDAC4(h) + AML3-isoform1(h) <==> HDAC4(h):AML3-isoform1(h) (binding)
Cdk5(m.s.) + HDAC4(h) <==> Cdk5(m.s.):HDAC4(h) (binding)
HDAC4(h) + calcineurin(m.s.) <==> HDAC4(h):calcineurin(m.s.) (binding)
HDAC4(h) --/ HDAC3(h) (decrease of abundance)
HDAC4(h) + NCOR1-isoform1(m) <==> HDAC4(h):NCOR1-isoform1(m) (binding)
HDAC4(h) + sumo1(m.s.) --Aos1(h):SAE2(h),Ubc9(m.s.)--> HDAC4(h){sumoK559} (sumoylation)
HDAC4(h) + sumo1(m.s.) --> HDAC4(h){sumoK559} (sumoylation)
HDAC4(h) + SUMO2(m.s.) --Aos1(h):SAE2(h),Ubc9(m.s.)--> HDAC4(h){sumo2K559} (sumoylation)
HDAC4(h) + NCOR1(m.s.) <==> HDAC4(h):NCOR1(m.s.) (binding)
MEF-2C(m.s.) + HDAC4(h) <==> MEF-2C(m.s.):HDAC4(h) (binding)
HDAC4(h) + 14-3-3epsilon(h) <==> HDAC4(h):14-3-3epsilon(h) (binding)
HDAC4(h) + HDAC4(h){sumoK559} <==> HDAC4(h):HDAC4(h){sumoK559} (binding)
2 HDAC4(h) <==> (HDAC4(h))2 (oligomerization)
HDAC4(h) + sumo1(m.s.) --Aos1(m.s.):SAE2(m.s.),Ubc9(m.s.),RanBP2(h)--> HDAC4(h){sumo} (sumoylation)
HDAC1(h) + HDAC4(h) <==> HDAC1(h):HDAC4(h) (binding)
HDAC4(h) + NCOR1(h) <==> HDAC4(h):NCOR1(h) (binding)
SMRT(m.s.) + HDAC4(h) <==> SMRT(m.s.):HDAC4(h) (binding)
SMRT(h) + HDAC4(h) <==> SMRT(h):HDAC4(h) (binding)
HDAC3(h) + HDAC4(h) <==> HDAC3(h):HDAC4(h) (binding)
Hp1-alpha(m) + HDAC4(h) <==> Hp1-alpha(m):HDAC4(h) (binding)
HDAC4(h) + Hp1-beta(m) <==> HDAC4(h):Hp1-beta(m) (binding)
HDAC4(h) + Hp1-gamma(m) <==> HDAC4(h):Hp1-gamma(m) (binding)
HDAC4(h) + SUV39H1(m.s.) <==> HDAC4(h):SUV39H1(m.s.) (binding)
HDAC4(h) + BCOR-isoform2(h) <==> HDAC4(h):BCOR-isoform2(h) (binding)
HDAC4(h) + BCOR-S(h) <==> HDAC4(h):BCOR-S(h) (binding)
HDAC4(h) + HDAC9-7(h) <==> HDAC4(h):HDAC9-7(h) (binding)
HDAC4(h) + GATA-1(m) <==> HDAC4(h):GATA-1(m) (binding)
HDAC4(h) --> HDAC4(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
246	Phosphoserine (by CaMK4).		Swiss-Prot 53.0
467	Phosphoserine (by CaMK4).		Swiss-Prot 53.0
632	Phosphoserine (by CaMK4).		Swiss-Prot 53.0
559	Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).		Swiss-Prot 53.0
467	Phosphoserine (CaM-KIV)	11470791	Phospho.ELM 6.0
632	Phosphoserine (CaM-KIV)	11470791	Phospho.ELM 6.0
246	Phosphoserine	10958686;10869435	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr2	Promoter: 239987080 - 239989080	Agilent_014791
chr2	Promoter: 239987080 - 239989080	GSE27584
chr2	Promoter: 239987080 - 239989080	Agilent_014791_44K
chr2	Promoter: 239987080 - 239989080	Agilent_014791

Transcription Factors [Top]

Post Translational Modification [Top]

Methylation Profile [Top]