| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 8517 |
Name | IKBKG |
Synonymous | AMCBX1|FIP-3|FIP3|Fip3p|IKK-gamma|IP|IP1|IP2|IPD2|NEMO;inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma;IKBKG;inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma |
Definition | I-kappa-B kinase subunit gamma|IKKAP1|IKKG|IkB kinase gamma subunit|NF-kappa-B essential modifier|NF-kappa-B essential modulator|NFkappaB essential modulator|ikB kinase subunit gamma|ikB kinase-associated protein 1|incontinentia pigmenti|inhibitor of nucl |
Position | Xq28 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | RIP(h) + IKK-gamma(h) <==> RIP(h):IKK-gamma(h) (binding) | A20(h) + IKK-gamma(h) <==> A20(h):IKK-gamma(h) (binding) | TNFR1(h) + IKK-gamma(h) <==> TNFR1(h):IKK-gamma(h) (binding) | IKK-gamma(h) + IKK-beta(h) + IKK-alpha(h) <==> IKK-alpha(h):IKK-beta(h):(IKK-gamma(h))2 (binding) | IKK-gamma(h) --> c-Jun(h) (activation; phosphorylation) | 2 IKK-beta(h) + 2 IKK-gamma(h) <==> (IKK-beta(h):IKK-gamma(h))2 (binding) | COPS3-xbb1(h) + IKK-gamma(h) <==> COPS3-xbb1(h):IKK-gamma(h) (binding) | IKK-gamma(h) + EAC(h) <==> IKK-gamma(h):EAC(h) (binding) | TANK(h) + IKK-gamma(h) + IKK-beta(h) <==> TANK(h):IKK-gamma(h):IKK-beta(h) (binding) | IKK-i(h) + TANK(h) + IKK-gamma(h) <==> IKK-i(h):TANK(h):IKK-gamma(h) (binding) | TBK1(h) + TANK(h) + IKK-gamma(h) <==> TBK1(h):TANK(h):IKK-gamma(h) (binding) | Ro52(h) + IKK-gamma(h) + IKK-beta(h) + IKK-alpha(h) + CBP(h) + TIF2(h) + SRC3(h) <==> Ro52(h):IKK-gamma(h):IKK-beta(h):IKK-alpha(h):CBP(h):TIF2(h):SRC3(h) (binding) | IKK-gamma(h) + IKK-beta(h) + CBP(h) + SRC3(h) <==> IKK-gamma(h):IKK-beta(h):CBP(h):SRC3(h) (binding) | IKK-gamma(h) + IKK-beta(h) + SRC3(h) <==> IKK-gamma(h):IKK-beta(h):SRC3(h) (binding) | IKK-gamma(h) + IKK-beta(h) <==> IKK-gamma(h):IKK-beta(h) (binding) | SRC3(h) + IKK-gamma(h) <==> SRC3(h):IKK-gamma(h) (binding) | IKK-gamma(h) + IRAK1(h) <==> IKK-gamma(h):IRAK1(h) (binding) | c-FLIP-p22(h) + IKK-gamma(h) <==> c-FLIP-p22(h):IKK-gamma(h) (binding) | IKK-gamma(h) + ATP --> IKK-gamma(h){pS85} + ADP (phosphorylation) | PIASy(h) + IKK-gamma(h) <==> PIASy(h):IKK-gamma(h) (binding) | IKK-gamma(h) + sumo1(h) --> IKK-gamma(h){sumo} (sumoylation) | IKK-gamma(h) + ubiquitin(h) --> IKK-gamma(h){ub} (ubiquitination) | IKK-gamma(h) + n ubiquitin(h) --> IKK-gamma(h){ub(n)K285} (ubiquitination) | PIDD(h) + RIP(h) + IKK-gamma(h) <==> PIDD(h):RIP(h):IKK-gamma(h) (binding) | IKK-gamma(h) + IKK-beta(h) + IKK-alpha(h) + Hsp50(h) + Hsp90(h) <==> IKK-gamma(h):IKK-beta(h):IKK-alpha(h):Hsp50(h):Hsp90(h) (binding) | parkin(h) + IKK-gamma(h) <==> parkin(h):IKK-gamma(h) (binding) | muc1(h) + IKK-gamma(h) <==> muc1(h):IKK-gamma(h) (binding) | muc1(m.s.) + IKK-gamma(h) + IKK-beta(h) <==> muc1(m.s.):IKK-gamma(h):IKK-beta(h) (binding) | IKK-gamma(h) + n ubiquitin(h) --> IKK-gamma(h){ub(n)} (ubiquitination) | IKK-gamma(h) + IKK-beta(h) + muc1(h) <==> IKK-gamma(h):IKK-beta(h):muc1(h) (binding) | IKK-gamma(h) + IKK-alpha(h) + IKK-beta(h) <==> IKK-gamma(h):IKK-alpha(h):IKK-beta(h) (binding) | RIP(h){ub}n + IKK-gamma(h) <==> RIP(h){ub}n:IKK-gamma(h) (binding) | CIKS(h) + IKK-gamma(h) <==> CIKS(h):IKK-gamma(h) (binding) | IKK-gamma(h) + IKK-beta(h) + IKK-alpha(h) + CIKS(h) <==> IKK-gamma(h):IKK-beta(h):IKK-alpha(h):CIKS(h) (binding) | IKK-gamma(h) + IRAK1(h){ub{K63}(n)} <==> IKK-gamma(h):IRAK1(h){ub{K63}(n)} (binding) | bcl10(h){ub(n)K63} + IKK-gamma(h) <==> bcl10(h){ub(n)K63}:IKK-gamma(h) (binding) | IKBKG(h) --> IKK-gamma(h) (expression). | IKK-gamma(h){ub{K63}(n)} --EAC(h)--> IKK-gamma(h) + n ubiquitin(h) (deubiquitination) | EAC(h) + NTP --IKK-gamma(h)--> EAC(h){p} + NDP (phosphorylation) | IkappaB-alpha(m.s.) + ATP --IKK-gamma(h)--> IkappaB-alpha(m.s.){pS32} + ADP (phosphorylation) | IKK-gamma(h) + sumo1(h) --> IKK-gamma(h){sumo} (sumoylation) | IKK-gamma(h) + sumo1(h) --PIASy(h),Ubc9(h)--> IKK-gamma(h){sumo} (sumoylation) | IKK-gamma(h) + PIASy(h) <==> IKK-gamma(h):PIASy(h) (binding) | IKK-gamma(h) + IKK-beta(h) <==> IKK-gamma(h):IKK-beta(h) (binding) | IKK-gamma(h) + sumo1(m) --> IKK-gamma(h){sumo} (sumoylation) | IKK-gamma(h) + 2 sumo1(h) --Ubc9(h)--> IKK-gamma(h){sumoK277}{sumoK309} (sumoylation) | IKK-gamma(h) + IKK-beta(m.s.) + RIP(m) <==> IKK-gamma(h):IKK-beta(m.s.):RIP(m) (binding) | IKK-beta(m.s.) + IKK-gamma(h) <==> IKK-beta(m.s.):IKK-gamma(h) (binding) | IKK-alpha(m.s.) + IKK-gamma(h) <==> IKK-alpha(m.s.):IKK-gamma(h) (binding) | IKK-gamma(h) + n ubiquitin(h) --> IKK-gamma(h){ub(n)} (ubiquitination) | parkin-isoform1(h) + IKK-gamma(h) <==> parkin-isoform1(h):IKK-gamma(h) (binding) | IRAK1-a(h) + IKK-gamma(h) <==> IRAK1-a(h):IKK-gamma(h) (binding) | IKK-gamma(h) + 3 ATP --> IKK-gamma(h){pS31}{pS43}{pS376} + 3 ADP (phosphorylation) | IKK-gamma(h) + n ubiquitin(h) --> IKK-gamma(h){ub}n (ubiquitination) | IKK-gamma(h) + 2 ubiquitin(h) --> IKK-gamma(h){ub}2 (ubiquitination) | IKK-gamma(h) + n ubiquitin(h) --> IKK-gamma(h){ub{K63}(n)} (ubiquitination) | IKK-gamma(h) --> IkappaB-alpha(m.s.){p} (increase of phosphorylation) | IKK-gamma(h) + IKK-alpha(h) <==> IKK-gamma(h):IKK-alpha(h) (binding) | IRAK1(h){ub{K63}(n)} + TAK1(h) + TRAF6(h) + IKK-gamma(h) <==> IRAK1(h){ub{K63}(n)}:TAK1(h):TRAF6(h):IKK-gamma(h) (binding) | IKK-gamma(h) + IRAK1-a(h){ub}n <==> IKK-gamma(h):IRAK1-a(h){ub}n (binding) | TRAF6(m) + IKK-gamma(h) <==> TRAF6(m):IKK-gamma(h) (binding) | IKBKG(h) --> IKK-gamma(h) (expression). | IKK-gamma(h){sumo} --senp1-isoform1(h)--> sumo1(h) + IKK-gamma(h) (desumoylation) | TNFR1(h) --> IKK-gamma(h) (increase of phosphorylation) |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 31 | Phosphoserine (IKK-beta) | 12657630 | Phospho.ELM 6.0 | 43 | Phosphoserine (IKK-beta) | 12657630 | Phospho.ELM 6.0 | 376 | Phosphoserine (IKK-beta) | 12657630 | Phospho.ELM 6.0 | 85 | Phosphoserine (ATM) | 16497931 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chrX |
Promoter: 153427756 - 153429756 | GoldenGate_Methylation_Cancer_Panel_I |
chrX |
Promoter: 153427756 - 153429756 | GSE27584 |