| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 7454 |
Name | WAS |
Synonymous | IMD2|SCNX|THC|THC1|WASP;Wiskott-Aldrich syndrome (eczema-thrombocytopenia);WAS;Wiskott-Aldrich syndrome (eczema-thrombocytopenia) |
Definition | thrombocytopenia 1 (X-linked)|wiskott-Aldrich syndrome protein |
Position | Xp11.4-p11.21 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | p21arc(h) + WASP(h) <==> p21arc(h):WASP(h) (binding) | G-actin(pg) + WASP(h) <==> G-actin(pg):WASP(h) (binding) | WASP(h) + WIP(h) <==> WASP(h):WIP(h) (binding) | WASP(h) + ATP --protein tyrosine kinases(v.s.)--> WASP(h){pY} + ADP (phosphorylation) | WASP(h) + RhoJ(h):GTP <==> WASP(h):RhoJ(h):GTP (binding) | WASP(h) + Cdc42(h):GTP <==> Cdc42(h):GTP:WASP(h) (binding) | Rac1(h):GTP + WASP(h) <==> Rac1(h):GTP:WASP(h) (binding) | Grb-2(h) + WASP(h) <==> Grb-2(h):WASP(h) (binding) | WASP(h) + Grb-2(v.s.) + EGFR(h){pY} <==> EGFR(h){pY}:Grb-2(v.s.):WASP(h) (binding) | Nck-1(m) + WASP(h) <==> Nck-1(m):WASP(h) (binding) | PLCgamma1(m.s.) + WASP(h) <==> PLCgamma1(m.s.):WASP(h) (binding) | WASP(h) + Src(m.s.) <==> WASP(h):Src(m.s.) (binding) | WASP(h) + p85alpha(m.s.) <==> WASP(h):p85alpha(m.s.) (binding) | WASP(h) + Fgr(m.s.) <==> WASP(h):Fgr(m.s.) (binding) | WASP(h) + Grb-2(m.s.) <==> WASP(h):Grb-2(m.s.) (binding) | WASP(h) + ATP --> WASP(h){pY} + ADP (phosphorylation) | WASP(h) --> SLP-76(h) (binding) | WASP(h) + CrkL(h) <==> WASP(h):CrkL(h) (binding) | WASP(h) + ATP --Fyn(m.s.)--> WASP(h){pY} + ADP (phosphorylation) | WASP(h) + Fyn(h) <==> WASP(h):Fyn(h) (binding) | PSTPIP1(h) + WASP(h) <==> PSTPIP1(h):WASP(h) (binding) | WASP(h) + PTP-PEST(h) <==> WASP(h):PTP-PEST(h) (binding) | WAS(h) --> WASP(h) (expression). | WASP(h) + Fyn(m.s.) <==> WASP(h):Fyn(m.s.) (binding) | WASP(h) + ATP --> WASP(h){pY291} + ADP (phosphorylation) | WASP(h) + ATP --Fyn(h)--> WASP(h){pY291} + ADP (phosphorylation) | WAS(h) --> WASP(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 291 | Phosphotyrosine. | Swiss-Prot 53.0 | 483 | Phosphoserine (by CK2). | Swiss-Prot 53.0 | 484 | Phosphoserine (by CK2). | Swiss-Prot 53.0 | 290 | Phosphotyrosine (BTK;HCK;CK2) | 10068673;12235133;15592455;12769847 | Phospho.ELM 6.0 | 483 | Phosphoserine (CK2 alpha) | 12769847 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chrX |
Promoter: 48425653 - 48427653 | Agilent_014791 |
chrX |
Promoter: 48425653 - 48427653 | IlluminaMethylation27 |
chrX |
Promoter: 48425653 - 48427653 | GSE27584 |