Entrez Gene

Basic Information
Gene ID	7430
Name	EZR
Synonymous	CVIL\|CVL\|VIL2;ezrin;EZR;ezrin
Definition	cytovillin 2\|p81\|villin 2 (ezrin)\|villin-2
Position	6q25.3
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
NHERF-1(h) + ezrin(h) <==> NHERF-1(h):ezrin(h) (binding)
ezrin(h) + MLCP(b) <==> ezrin(h):MLCP(b) (binding)
hamartin(m) + ezrin(h) <==> hamartin(m):ezrin(h) (binding)
p85(h) + p110alpha(h) + Hsp50(h) + Hsp90(h) + ezrin(h) + CD44(h) + ErbB2(h){p} <==> p85(h):p110alpha(h):Hsp50(h):Hsp90(h):ezrin(h):CD44(h):ErbB2(h){p} (binding)
p110alpha(h) + Hsp50(h) + ezrin(h) + CD44(h) + ErbB2(h){p} <==> p110alpha(h):Hsp50(h):ezrin(h):CD44(h):ErbB2(h){p} (binding)
Hsp50(h) + ezrin(h) + CD44(h) + ErbB2(h){p} <==> Hsp50(h):ezrin(h):CD44(h):ErbB2(h){p} (binding)
Gem(h) + ezrin(h) <==> Gem(h):ezrin(h) (binding)
Gem(h) + ezrin(h) <==> Gem(h):ezrin(h) (binding)
ezrin(h) + 2 ATP --> ezrin(h){pY146}{pY354} + 2 ADP (phosphorylation)
AMPKbeta-1(h) + ezrin(h) <==> AMPKbeta-1(h):ezrin(h) (binding)
GATE-16(h) + ezrin(h) <==> GATE-16(h):ezrin(h) (binding)
MCC1(h) + ezrin(h) <==> MCC1(h):ezrin(h) (binding)
ezrin(h) + ATP --> ezrin(h){pT567} + ADP (phosphorylation)
CD43(h) + ezrin(h) <==> CD43(h):ezrin(h) (binding)
ezrin(h) + ZAP-70(h) <==> ezrin(h):ZAP-70(h) (binding)
EZR(h) --> ezrin(h) (expression).
EZR(h) --> ezrin(h) (expression).
EZR(h) --> ezrin(h) (expression).
hsa-miR-183 --/ ezrin(h) (translational repression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
146	Phosphotyrosine (by PDGFR).		Swiss-Prot 53.0
354	Phosphotyrosine (by PDGFR).		Swiss-Prot 53.0
353	Phosphotyrosine (EGFR)	1382070	Phospho.ELM 6.0
145	Phosphotyrosine (Lck;EGFR)	1382070;12560083	Phospho.ELM 6.0
477	Phosphotyrosine (Src)	15623525	Phospho.ELM 6.0
566	Phosphothreonine (GRK-2;ROCK1;)	10970850;15843435;15531580;14504278	Phospho.ELM 6.0

Transcription Factors [Top]