Entrez Gene

Basic Information
Gene ID	7080
Name	NKX2-1
Synonymous	BCH\|BHC\|NK-2\|NKX2.1\|NKX2A\|TEBP\|TITF1\|TTF-1\|TTF1;NK2 homeobox 1;NKX2-1;NK2 homeobox 1
Definition	NK-2 homolog A\|homeobox protein NK-2 homolog A\|homeobox protein Nkx-2.1\|thyroid nuclear factor 1\|thyroid transcription factor 1
Position	14q13
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
TTF-1(h) --> Scgb1a1(r) (DNA binding; transactivation).
TTF-1(h) --> Sftpa1(r) (DNA binding; transactivation).
TTF-1(h) --> AFP(r) (DNA binding).
TTF-1(h) + RelA-p65(h) <==> TTF-1(h):RelA-p65(h) (binding)
CCDC59(h) + TTF-1(h) <==> CCDC59(h):TTF-1(h) (binding)
TTF-1(h) + Smad3(m.s.) <==> TTF-1(h):Smad3(m.s.) (binding)
TTF-1(h) --> SP-B(h) (transactivation)
TTF-1(h) --> TG(h) (DNA binding; transactivation).
TTF-1(h) --> Scgb3a2(m) (DNA binding).
TTF-1(h) --> Tg(r) (DNA binding).
TTF-1(h) --> Cldn18(m) (DNA binding).
TTF-1(h) --> SCGB3A2(h) (DNA binding; transactivation).
NKX2-1(h) --> TTF-1(h) (expression).
IL-1alpha(m.s.) --/ TTF-1(h) (decrease of abundance)
TTF-1-isoform1(h) --> SP-B(h) (DNA binding; transactivation).
TTF-1-isoform1(h) --> T1alpha(r) (DNA binding).
TTF-1-isoform1(h) --> Scgb1a1(m) (DNA binding; transactivation).
TTF-1-isoform1(h) --> SP-B(rb) (DNA binding; transactivation).
TTF-1-isoform1(h) --> SP-A1(ph) (DNA binding; transactivation).
TTF-1-isoform1(h) --> SFTPA2B(ph) (DNA binding; transactivation).
TTF-1-isoform1(h) --> Wnt7b(m) (DNA binding; transactivation).
TTF-1-isoform1(h) --> FOXA1(m) (DNA binding; transactivation).
TTF-1-isoform1(h) --> Foxa1(r) (DNA binding; transactivation).
NKX2-1(h) --> TTF-1-isoform1(h) (expression).
NKX2-1(h) --> TTF-1-isoform2(h) (expression).

Post Translational Modification [Top]
	There is no record for NKX2-1

Transcription Factors [Top]