| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 6886 |
Name | TAL1 |
Synonymous | SCL|TCL5|bHLHa17|tal-1;T-cell acute lymphocytic leukemia 1;TAL1;T-cell acute lymphocytic leukemia 1 |
Definition | T-cell acute lymphocytic leukemia protein 1|T-cell leukemia/lymphoma protein 5|class A basic helix-loop-helix protein 17|stem cell protein|tal-1 product |
Position | 1p32 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Tal1-PP42(h) --> IgH(m) (DNA binding). | Tal1-PP42(h) + E12(h) <==> Tal1-PP42(h):E12(h) (binding). | Tal1-PP42(h) + E47(h) <==> Tal1-PP42(h):E47(h) (binding) | Tal1-PP42(h) + IEBP1(r) <==> Tal1-PP42(h):IEBP1(r) (binding). | Tal1-PP42(h) + ITF-2(h) <==> Tal1-PP42(h):ITF-2(h) (binding). | Tal1-PP42(h) + E47(r) <==> Tal1-PP42(h):E47(r) (binding). | Tal1-PP42(h) + E47(m) <==> Tal1-PP42(h):E47(m) (binding). | Tal1-PP42(h) + Lmo1(h) <==> Tal1-PP42(h):Lmo1(h) (binding). | Tal1-PP42(h) + RBTN2-isoform1(h) <==> Tal1-PP42(h):RBTN2-isoform1(h) (binding). | Tal1-PP42(h) + ATP --AKT-1(m)--> Tal1-PP42(h){pT90} + ADP (phosphorylation) | Tal1-PP42(h) + ATP --AKT(h){pS473}--> Tal1-PP42(h){p} + ADP (phosphorylation) | Tal1-PP42(h) + AKT-1(m.s.) <==> Tal1-PP42(h):AKT-1(m.s.) (binding) | Tal1-PP42(h) + ATP --AKT(m.s.)--> Tal1-PP42(h){p} + ADP (phosphorylation) | Tal1-PP42(h) + ATP --> Tal1-PP42(h){pT90} + ADP (phosphorylation) | TAL1(h) --> Tal1-PP42(h) (expression). | Tal1-PP22(h) --> IgH(m) (DNA binding). | Tal1-PP22(h) + E47(h) <==> Tal1-PP22(h):E47(h) (binding) | Tal1-PP22(h) + ITF-2(h) <==> Tal1-PP22(h):ITF-2(h) (binding). | TAL1(h) --> Tal1-PP22(h) (expression). | CLIM2(h) + E2A(h) + RBTN2-isoform1(h) + Tal-1(h) <==> CLIM2(h):E2A(h):RBTN2-isoform1(h):Tal-1(h) (binding) | CLIM2(h) + E2A(h) + RBTN2-isoform1(h) + Tal-1(h) + pRb(h) <==> CLIM2(h):E2A(h):RBTN2-isoform1(h):Tal-1(h):pRb(h) (binding) | pRb(h) + Tal-1(h) <==> pRb(h):Tal-1(h) (binding) | Tal-1(h) + sin3a(h) <==> Tal-1(h):sin3a(h) (binding) | SUV39H1(h) + Tal-1(h) <==> SUV39H1(h):Tal-1(h) (binding) | SATB1(h) + Tal-1(h) <==> SATB1(h):Tal-1(h) (binding) | TAL1(h) --> Tal-1(h) (expression). | TAL1(h) --> Tal1-PP39(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 122 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 122 | Phosphoserine (MAP2K1) | 8423803 | Phospho.ELM 6.0 | 90 | Phosphothreonine | 15930267 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr1 |
Promoter: 47467530 - 47469530 | Agilent_014791 |
chr1 |
Promoter: 47467530 - 47469530 | GoldenGate_Methylation_Cancer_Panel_I |
chr1 |
Promoter: 47467530 - 47469530 | GSE27584 |