| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 5979 |
Name | RET |
Synonymous | CDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1|RET51;ret proto-oncogene;RET;ret proto-oncogene |
Definition | RET transforming sequence|cadherin family member 12|cadherin-related family member 16|hydroxyaryl-protein kinase|proto-oncogene c-Ret|proto-oncogene tyrosine-protein kinase receptor Ret|receptor tyrosine kinase|ret proto-oncogene (multiple endocrine neopl |
Position | 10q11.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | RET(h) --> Ret-1(h) (expression). | RET(h) --> Ret-2(h) (expression). | NTN(h) + GFR-alpha-2(h) + Ret(h) <==> NTN(h):GFR-alpha-2(h):Ret(h) (binding) | Ret(h) + SHP-1(h) <==> Ret(h):SHP-1(h) (binding) | RET(h) --> Ret(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 98 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 151 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 199 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 336 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 343 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 361 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 367 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 377 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 394 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 448 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 468 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 554 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 806 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 809 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 900 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 905 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 981 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 1015 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 1062 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 1090 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 1096 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 687 | Phosphotyrosine (Ret) | 11470823;8621380 | Phospho.ELM 6.0 | 1015 | Phosphotyrosine (Ret) | 11470823;14981541 | Phospho.ELM 6.0 | 1029 | Phosphotyrosine (Ret) | 11470823;8621380;14766744 | Phospho.ELM 6.0 | 1062 | Phosphotyrosine (Ret) | 11470823;14711813;14981541 | Phospho.ELM 6.0 | 1096 | Phosphotyrosine (Ret) | 11470823;8621380;14711813 | Phospho.ELM 6.0 | 826 | Phosphotyrosine (Ret) | 11470823;8621380 | Phospho.ELM 6.0 | 1090 | Phosphotyrosine (Ret) | 14711813 | Phospho.ELM 6.0 | 806 | Phosphotyrosine (Ret) | 14711813 | Phospho.ELM 6.0 | 809 | Phosphotyrosine (Ret) | 14711813 | Phospho.ELM 6.0 | 900 | Phosphotyrosine (Ret) | 14711813 | Phospho.ELM 6.0 | 905 | Phosphotyrosine (Ret) | 14711813 | Phospho.ELM 6.0 | 981 | Phosphotyrosine (Ret) | 14711813;14766744 | Phospho.ELM 6.0 | 696 | Phosphoserine | 11886862 | Phospho.ELM 6.0 | 891 | Phosphoserine | 15753368 | Phospho.ELM 6.0 | 791 | Phosphotyrosine | 15753368 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr10 |
Promoter: 42891033 - 42893033 | Agilent_014791 |
chr10 |
Promoter: 42891033 - 42893033 | GoldenGate_Methylation_Cancer_Panel_I |
chr10 |
Promoter: 42891033 - 42893033 | GoldenGate_Methylation_Cancer_Panel_I |
chr10 |
Promoter: 42891033 - 42893033 | GSE27584 |
chr10 |
Promoter: 42891033 - 42893033 | GSE27584 |
chr10 |
Promoter: 42891033 - 42893033 | Agilent_014791_44K |