Entrez Gene

Basic Information
Gene ID	5978
Name	REST
Synonymous	NRSF\|XBR;RE1-silencing transcription factor;REST;RE1-silencing transcription factor
Definition	neural-restrictive silencer factor\|neuron restrictive silencer factor\|repressor binding to the X2 box
Position	4q12
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
REST(h) --> REST form2(h) (expression).
REST(h) --> REST-form1(h) (expression).
huntingtin(h) + REST(h) <==> huntingtin(h):REST(h) (binding)
REST(h) --/ Acta1(m) (DNA binding; transrepression).
REST(h) --/ Grin1(r) (DNA binding; transrepression).
REST(h) --> Calb1(m) (DNA binding; transregulation).
REST(h) --/ BDNF(r) (DNA binding; transrepression).
REST(h) --/ CRH(m) (DNA binding; transrepression).
REST(h) --/ CX36(h) (DNA binding; transrepression).
REST(h) --/ Pax4(m) (DNA binding; transrepression).
REST(h) --/ Chat(r) (DNA binding; transrepression).
REST(h) --/ Scn2a1(r) (DNA binding; transrepression).
REST(h) --> TBB4(c) (DNA binding; transregulation).
REST(h) --> NEFM(c) (DNA binding; transregulation).
REST(h) --/ SYP(r) (DNA binding; transrepression).
REST(h) --> APRT(r) (DNA binding; transregulation).
REST(h) --> CYP11B1(h) (DNA binding; transregulation).
REST(h) --> Nppa(r) (DNA binding; transregulation).
REST(h) --/ SYN1(h) (DNA binding; transrepression).
REST(h) --/ MAPK8IP1(h) (DNA binding; transrepression).
REST(h) --/ Stmn2(r) (DNA binding; transrepression).
REST(h) --/ GABAA-RD(r) (DNA binding; transrepression).
REST(h) --/ CHRNB2(h) (DNA binding; transrepression).
REST(h) --> L1CAM(h) (DNA binding; transregulation).
REST(h) --/ AVP(h) (DNA binding; transrepression).
REST(h) + G9A(m.s.) <==> REST(h):G9A(m.s.) (binding)
Sp3(h) + REST(h) <==> Sp3(h):REST(h) (binding)
REST(h) --> CYP1A1(r) (DNA binding).
REST(h) --> CYP2E1(r) (DNA binding).
REST(h) --> TH(h) (DNA binding).
REST(h) --> CYP3A2(r) (DNA binding).
REST(h) --/ OPRM1(h) (DNA binding; transrepression).
REST(h) --> NRP1(h) (DNA binding).
REST(h) --> NTRK3(h) (DNA binding).
REST(h) --> Cyp2a2(r) (DNA binding).
REST(h) --/ Gabrg2(m) (DNA binding; transrepression).
REST(h) --> CHRM4(r) (DNA binding).
REST(h) --> CHRM1(r) (DNA binding).
REST(h) --> DBH(r) (DNA binding).
REST(h) --> TAC1(h) (DNA binding).
REST(h) --> REST(h) (expression).
Rest isoform1(h) + sin3a(m.s.) <==> Rest isoform1(h):sin3a(m.s.) (binding)
sin3a(h) + Rest isoform1(h) <==> sin3a(h):Rest isoform1(h) (binding)
REST(h) --> Rest isoform1(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
864	Phosphoserine.		Swiss-Prot 53.0
864	Phosphoserine	15302935	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr4	Promoter: 57467299 - 57469299	Agilent_014791
chr4	Promoter: 57467299 - 57469299	GSE27584
chr4	Promoter: 57467299 - 57469299	Agilent_014791_44K

Transcription Factors [Top]

Post Translational Modification [Top]

Methylation Profile [Top]