| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 5624 |
Name | PROC |
Synonymous | APC|PC|PROC1;protein C (inactivator of coagulation factors Va and VIIIa);PROC;protein C (inactivator of coagulation factors Va and VIIIa) |
Definition | anticoagulant protein C|autoprothrombin IIA|blood coagulation factor XIV|vitamin K-dependent protein C |
Position | 2q13-q14 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | PROC(h) --> mmp2(h) (activation) | PROC(h) + EPCR(h) <==> PROC(h):EPCR(h) (binding) | Protein C precursor(h) --> PROC(h) (expression). | Protein C precursor(h) --> PROC(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 48 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 49 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 56 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 58 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 61 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 62 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 67 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 68 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 71 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 113 | 3-hydroxyaspartate. | Swiss-Prot 53.0 | 139 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 290 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 355 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 371 | N-linked (GlcNAc...); partial; atypical. | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr2 |
Promoter: 127890987 - 127892987 | Agilent_014791 |
chr2 |
Promoter: 127890987 - 127892987 | GSE27584 |