Entrez Gene

Basic Information
Gene ID	5588
Name	PRKCQ
Synonymous	PRKCT\|nPKC-theta;protein kinase C, theta;PRKCQ;protein kinase C, theta
Definition	protein kinase C theta type
Position	10p15
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
14-3-3tau(h) + PKCtheta(h) <==> 14-3-3tau(h):PKCtheta(h) (binding)
PKCtheta(h) + L-selectin(h) <==> PKCtheta(h):L-selectin(h) (binding)
L-selectin(h){pS} + PKCtheta(h) <==> L-selectin(h){pS}:PKCtheta(h) (binding)
Btk(h) + PKCtheta(h) <==> Btk(h):PKCtheta(h) (binding)
Btk(h) + PKCtheta(h) <==> Btk(h):PKCtheta(h) (binding)
PKCtheta(h) + ATP --> PKCtheta(h){pY} + ADP (phosphorylation)
PKCtheta(h) + ATP --> PKCtheta(h){p} + ADP (phosphorylation; automodification)
PKCtheta(h) + c-Cbl(h) <==> PKCtheta(h):c-Cbl(h) (binding)
PKCtheta(h) + c-Cbl(h) <==> PKCtheta(h):c-Cbl(h) (binding)
PKCtheta(h) + SPAK(h) <==> PKCtheta(h):SPAK(h) (binding)
PKCtheta(h) + SPAK(m.s.) <==> PKCtheta(h):SPAK(m.s.) (binding)
PKCtheta(h) + 2 ATP --> PKCtheta(h){pT692}{pT703} + 2 ADP (phosphorylation)
PKCtheta(h) + ATP --> PKCtheta(h){pT538} + ADP (phosphorylation)
PKCtheta(h) --> PKCtheta(h) (translocation)
Prkcq(h) --> PKCtheta(h) (expression).
PKCtheta(h) --> PKCtheta(h) (translocation)
L-selectin(h) + ATP --PKCtheta(h)--> L-selectin(h){pS} + ADP (phosphorylation)
c-Cbl(h) + ATP --PKCtheta(h)--> c-Cbl(h){p} + ADP (phosphorylation)
c-Cbl(h) + ATP --PKCtheta(h)--> c-Cbl(h){p} + ADP (phosphorylation)
CYP7(h) + ATP --PKCtheta(h)--> CYP7(h){p} + ADP (phosphorylation)
Prkcq(h) --> PKCtheta-isoform1(h) (expression).
Prkcq(h) --> PKCtheta-isoform2(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
219	Phosphothreonine (by autocatalysis).		Swiss-Prot 53.0
538	Phosphothreonine.		Swiss-Prot 53.0
676	Phosphoserine.		Swiss-Prot 53.0
685	Phosphoserine.		Swiss-Prot 53.0
695	Phosphoserine.		Swiss-Prot 53.0
90	Phosphotyrosine (Lck)	10652356	Phospho.ELM 6.0
538	Phosphothreonine	11772397	Phospho.ELM 6.0
676	Phosphoserine	11772397	Phospho.ELM 6.0
695	Phosphoserine	11772397	Phospho.ELM 6.0
219	Phosphothreonine (PKC theta)	16252004	Phospho.ELM 6.0

Transcription Factors [Top]