Entrez Gene

Basic Information
Gene ID	5243
Name	ABCB1
Synonymous	ABC20\|CD243\|CLCS\|GP170\|MDR1\|P-GP\|PGY1;ATP-binding cassette, sub-family B (MDR/TAP), member 1;ABCB1;ATP-binding cassette, sub-family B (MDR/TAP), member 1
Definition	P-glycoprotein 1\|colchicin sensitivity\|doxorubicin resistance\|multidrug resistance protein 1
Position	7q21.12
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
ABCB1(h) --> MDR-1(h) (expression).
MDR-1(h) --> MDR-1-p85(h) + protein remnants (cleavage)
MDR-1(h) --> MDR-1-p80(h) + protein remnants (cleavage)
MDR-1(h) --Caspase-3(h)--> MDR-1-p85(h) + protein remnants (cleavage)
MDR-1(h) --Caspase-3(h)--> MDR-1-p80(h) + protein remnants (cleavage)
MDR-1(h) + CD44(h) + ANK2(h) <==> MDR-1(h):CD44(h):ANK2(h) (binding)
MDR-1(h) + n ubiquitin(h) --> MDR-1(h){ub}n (ubiquitination)
MDR-1(h) --26S proteasome(h)--> protein remnants (degradation)
ABCB1(h) --> MDR-1(h) (expression).
LYRIC(m.s.) --> MDR-1(h) (increase of abundance)

Location (AA)	PTM type	Database
Post Translational Modification [Top]
91	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
94	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
99	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0

Transcription Factors [Top]