| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 5058 |
Name | PAK1 |
Synonymous | PAKalpha;p21 protein (Cdc42/Rac)-activated kinase 1;PAK1;p21 protein (Cdc42/Rac)-activated kinase 1 |
Definition | STE20 homolog, yeast|alpha-PAK|p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)|p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)|p65-PAK|serine/threonine-protein kinase PAK 1 |
Position | 11q13-q14 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | p65PAK(h) + alpha-PIX(h) + CAT2(h) <==> p65PAK(h):alpha-PIX(h):CAT2(h) (binding) | p65PAK(h) + CAT2(h) + Cool1-isoform1(h) <==> p65PAK(h):CAT2(h):Cool1-isoform1(h) (binding) | p65PAK(h) + p56Dok-2(m){pY} + Tie2(m){pY} <==> p65PAK(h):p56Dok-2(m){pY}:Tie2(m){pY} (binding) | LIMK1(h) + p65PAK(h) <==> LIMK1(h):p65PAK(h) (binding) | p65PAK(h) + ATP --p65PAK(h)--> p65PAK(h){pT423} + ADP (phosphorylation) | p65PAK(h) + ATP --PDK1(h){pS241}--> p65PAK(h){pT423} + ADP (phosphorylation) | Grb-2(h) + p65PAK(h) <==> Grb-2(h):p65PAK(h) (binding) | p65PAK(h) + RhoJ(h):GTP <==> p65PAK(h):RhoJ(h):GTP (binding) | HRS(h) + p65PAK(h) <==> HRS(h):p65PAK(h) (binding) | p65PAK(h) + Cdk5(v.s.):CDK5R1p35(v.s.) <==> p65PAK(h):Cdk5(v.s.):CDK5R1p35(v.s.) (binding) | Nck-1(h) + p65PAK(h) <==> Nck-1(h):p65PAK(h) (binding) | p65PAK(h) + STAT5A(m) <==> p65PAK(h):STAT5A(m) (binding) | p65PAK(h) --> PR(h) (increase of abundance) | p65PAK(h) --> TFF1(h) (increase of abundance) | p65PAK(h) --> Raf-1(h):Bcl-2(h) (increase of binding) | Rac1(h):GTP + p65PAK(h) <==> p65PAK(h):Rac1(h):GTP (binding) | p65PAK(h) --> bad(m.s.){pS112} (increase of phosphorylation) | p65PAK(h) --> ERK1(h){p} (increase of phosphorylation) | p65PAK(h) --> ERK2(h){p} (increase of phosphorylation) | p65PAK(h) + PITSLREalpha(h) <==> p65PAK(h):PITSLREalpha(h) (binding) | Rac1(m.s.):GTP + p65PAK(h) <==> Rac1(m.s.):GTP:p65PAK(h) (binding) | p65PAK(h) + ATP --> p65PAK(h){p} + ADP (phosphorylation; automodification) | p65PAK(h) + Rac1(h) <==> p65PAK(h):Rac1(h) (binding) | Rac2(h) + p65PAK(h) <==> Rac2(h):p65PAK(h) (binding) | p65PAK(h) + Cdc42(m.s.) <==> p65PAK(h):Cdc42(m.s.) (binding) | ArgBP2(h) + p65PAK(h) <==> ArgBP2(h):p65PAK(h) (binding) | p65PAK(h) + Dncic1(h) <==> p65PAK(h):Dncic1(h) (binding) | p65PAK(h) + LC8(h) <==> p65PAK(h):LC8(h) (binding) | PKCzeta(h) + p65PAK(h) <==> PKCzeta(h):p65PAK(h) (binding) | TCoB(h) + p65PAK(h) <==> TCoB(h):p65PAK(h) (binding) | arpc1a(h) + p65PAK(h) <==> arpc1a(h):p65PAK(h) (binding) | p65PAK(h) + p34arc(h) + Arp2(h) + Arp3(h) + arpc1a(h) <==> p65PAK(h):p34arc(h):Arp2(h):Arp3(h):arpc1a(h) (binding) | G-beta-1(b):G-gamma-2(b) + p65PAK(h) <==> G-beta-1(b):G-gamma-2(b):p65PAK(h) (binding) | p65PAK(h) + ER-alpha(h) <==> p65PAK(h):ER-alpha(h) (binding) | p65PAK(h) --> cyclinD1(h) (increase of abundance) | p65PAK(h) --> ER-alpha(h){pS118} (increase of phosphorylation) | ESE-1(h) + p65PAK(h) <==> ESE-1(h):p65PAK(h) (binding) | p65PAK(h) --> PTGS2(h) (transactivation) | p65PAK(h) + Nck-1(h) <==> p65PAK(h):Nck-1(h) (binding) | p65PAK(h) + ERK1(r){p} <==> p65PAK(h):ERK1(r){p} (binding) | p65PAK(h) + ERK2(r){p} <==> p65PAK(h):ERK2(r){p} (binding) | p65PAK(h) + ERK2(r) <==> p65PAK(h):ERK2(r) (binding) | p65PAK(h) + ATP --ERK2(r)--> p65PAK(h){pT212} + ADP (phosphorylation) | p65PAK(h) + Rac1(r) <==> p65PAK(h):Rac1(r) (binding) | CIB(h) + p65PAK(h) <==> CIB(h):p65PAK(h) (binding) | p65PAK(h) + CIB(m.s.) <==> p65PAK(h):CIB(m.s.) (binding) | p65PAK(h) + ATP --> p65PAK(h){pT423} + ADP (phosphorylation) | ErbB2(h) + actin(h) + p65PAK(h) <==> ErbB2(h):actin(h):p65PAK(h) (binding) | CAT2(v.s.) + p65PAK(h) + Cool-1(h) + paxillin(c) <==> CAT2(v.s.):p65PAK(h):paxillin(c):Cool-1(h) (binding) | p65PAK(h) + Cdc42(h) <==> p65PAK(h):Cdc42(h) (binding) | p65PAK(h) + Rac1(m.s.) <==> p65PAK(h):Rac1(m.s.) (binding) | p65PAK(h) + p38(m.s.){p} <==> p65PAK(h):p38(m.s.){p} (binding) | p65PAK(h) + ATP --> p65PAK(h){pS144} + ADP (phosphorylation) | IL-3(m) --> p65PAK(h) (activation) | PAK1(h) --> p65PAK(h) (expression). | LIMK1(h):p65PAK(h) + ATP --> LIMK1(h){pT508} + p65PAK(h) + ADP (phosphorylation; dissociation) | LAMA5(h) --> p65PAK(h) (activation) | Cdc42(h) --> p65PAK(h) (activation) | bad(m) + ATP --p65PAK(h)--> bad(m){pS} + ADP (phosphorylation) | bad(h) + ATP --p65PAK(h)--> ADP + bad(h){pS} (phosphorylation) | p65PAK(h) + ATP --p65PAK(h)--> p65PAK(h){pT423} + ADP (phosphorylation) | MLCK(v.s.) + ATP --p65PAK(h)--> MLCK(v.s.){p} + ADP (phosphorylation) | STAT5A(m) + ATP --p65PAK(h)--> STAT5A(m){pS779} + ADP (phosphorylation) | Raf-1(h) + ATP --p65PAK(h)--> Raf-1(h){pS338} + ADP (phosphorylation) | LC8(h) + ATP --p65PAK(h)--> LC8(h){p} + ADP (phosphorylation) | PKCzeta(h) + ATP --p65PAK(h)--> PKCzeta(h){p} + ADP (phosphorylation) | TCoB(h) + ATP --p65PAK(h)--> TCoB(h){p} + ADP (phosphorylation) | TCoB(h) + ATP --p65PAK(h)--> TCoB(h){p} + ADP (phosphorylation) | Cat-1(h) + ATP --p65PAK(h)--> Cat-1(h){pS} + ADP (phosphorylation) | ESE-1(m.s.) + ATP --p65PAK(h)--> ESE-1(m.s.){pS207} + ADP (phosphorylation) | vasp(h) + ATP --p65PAK(h)--> vasp(h){pS239} + ADP (phosphorylation) | p65PAK-isoform1(h) + ArgBP2(h) <==> p65PAK-isoform1(h):ArgBP2(h) (binding) | p65PAK-isoform1(h) + p65PAK(r) <==> p65PAK-isoform1(h):p65PAK(r) (binding) | Cdc42(m.s.) + p65PAK-isoform1(h) <==> Cdc42(m.s.):p65PAK-isoform1(h) (binding) | p65PAK-isoform1(h) + ATP --> p65PAK-isoform1(h){pT423} + ADP (phosphorylation) | p65PAK-isoform1(h) + ATP --> p65PAK-isoform1(h){p} + ADP (phosphorylation; automodification) | TCoB(h) + p65PAK-isoform1(h) <==> TCoB(h):p65PAK-isoform1(h) (binding) | TCoB(h) + p65PAK-isoform1(h) <==> TCoB(h):p65PAK-isoform1(h) (binding) | 2 p65PAK-isoform1(h) <==> (p65PAK-isoform1(h))2 (binding) | ESE-1(m.s.) + p65PAK-isoform1(h) <==> ESE-1(m.s.):p65PAK-isoform1(h) (binding) | Nischarin(m) + p65PAK-isoform1(h) <==> Nischarin(m):p65PAK-isoform1(h) (binding) | p65PAK-isoform1(h) + Nischarin(m) + beta1-integrin(m.s.) <==> p65PAK-isoform1(h):Nischarin(m):beta1-integrin(m.s.) (binding) | p65PAK-isoform1(h) + ATP --> p65PAK-isoform1(h){pS199}{pS204} + ADP (phosphorylation) | p65PAK-isoform1(h) + DLC2(h) <==> p65PAK-isoform1(h):DLC2(h) (binding) | DLC2(h) + p65PAK-isoform1(h) <==> DLC2(h):p65PAK-isoform1(h) (binding) | DLC2(m.s.) + p65PAK-isoform1(h) <==> DLC2(m.s.):p65PAK-isoform1(h) (binding) | p65PAK-isoform1(h) + LC8(m.s.) <==> p65PAK-isoform1(h):LC8(m.s.) (binding) | PAK1(h) --> p65PAK-isoform1(h) (expression). | MBP(m.s.) + ATP --p65PAK-isoform1(h)--> MBP(m.s.){p} + ADP (phosphorylation) | bad(m.s.) + 2 ATP --p65PAK-isoform1(h)--> bad(m.s.){pS112}{pS136} + 2 ADP (phosphorylation) | PAK1(h) --> p65PAK-isoform2(h) (expression). |
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Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 21 | Phosphoserine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 57 | Phosphoserine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 84 | Phosphothreonine (by OXSR1) (Bysimilarity). | Swiss-Prot 53.0 | 144 | Phosphoserine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 149 | Phosphoserine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 199 | Phosphoserine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 204 | Phosphoserine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 212 | Phosphothreonine. | Swiss-Prot 53.0 | 220 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 223 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 225 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 423 | Phosphothreonine (by autocatalysis)(Probable). | Swiss-Prot 53.0 | 423 | Phosphothreonine (PAK1;PDK-1) | 10995762;11134074 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr11 |
Promoter: 76862081 - 76864081 | Agilent_014791 |
chr11 |
Promoter: 76862081 - 76864081 | GSE27584 |
chr11 |
Promoter: 76862081 - 76864081 | Agilent_014791_44K |