| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 4843 |
Name | NOS2 |
Synonymous | HEP-NOS|INOS|NOS|NOS2A;nitric oxide synthase 2, inducible;NOS2;nitric oxide synthase 2, inducible |
Definition | NOS type II|NOS, type II|hepatocyte NOS|inducible NO synthase|inducible NOS|nitric oxide synthase 2A (inducible, hepatocytes)|nitric oxide synthase, inducible|nitric oxide synthase, macrophage|peptidyl-cysteine S-nitrosylase NOS2 |
Position | 17q11.2-q12 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | iNOS(h) + ATP --> iNOS(h){pS} + ADP (phosphorylation) | iNOS(h) + ATP --ERK1(m.s.)--> iNOS(h){pS745} + ADP (phosphorylation) | ERK1(h) + iNOS(h) <==> ERK1(h):iNOS(h) (binding) | ERK(h) + iNOS(h) <==> ERK(h):iNOS(h) (binding) | NOS2(h) --> iNOS(h) (expression). | caveolin-1(m.s.) --/ iNOS(h) (inhibition) | HCV-core-1B(HCV1B) --> iNOS(h) (increase of abundance) | EGF(m.s.) --> iNOS(h) (increase of abundance) | Caveolin-3(m.s.) --/ iNOS(h) (inhibition) | IL-17A(h) --> iNOS(h) (increase of abundance) | NOS2(h) --> iNOS-isoform1(h) (expression). | NOS2(h) --> iNOS-isoform2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
There is no record for NOS2 | |||
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr17 |
Promoter: 23151182 - 23153182 | GoldenGate_Methylation_Cancer_Panel_I |
chr17 |
Promoter: 23151182 - 23153182 | GSE27584 |