| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 4254 |
Name | KITLG |
Synonymous | FPH2|KL-1|Kitl|MGF|SCF|SF|SHEP7|kit-ligand;KIT ligand;KITLG;KIT ligand |
Definition | c-Kit ligand|familial progressive hyperpigmentation 2|kit ligand|mast cell growth factor|steel factor|stem cell factor |
Position | 12q22 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | 2 SCF(h) <==> (SCF(h))2 (binding; oligomerization) | SCF(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation) | SCF(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | SCF(h) + c-Kit(h) <==> SCF(h):c-Kit(h) (binding) | SCF(h) --> ERK2(m.s.){p} (increase of phosphorylation) | KITLG(h) --> SCF(h) (expression). | p53(h) --> SCF(h) (increase of abundance) | UV-B --> SCF(h) (increase of abundance) | SCF-isoform1(h) --> Gab-2(m){pY} (increase of phosphorylation) | SCF-isoform1(h) --> AKT(m){pS473} (increase of phosphorylation) | SCF-isoform1(h) --> p85alpha(m) (increase of abundance) | SCF-isoform1(h) --> p85alpha(m):c-Kit(m) (increase of binding) | SCF-isoform1(h) --> p85alpha(m):Gab-2(m) (increase of binding) | SCF-isoform1(h) --> Gab-2(m):p110alpha(m) (increase of binding) | SCF-isoform1(h) --> c-Kit(m):p110alpha(m) (increase of binding) | SCF-isoform1(h) --> c-Kit(h){ub} (increase of ubiquitination) | SCF-isoform1(h) --> c-Cbl(mo){pY} (increase of phosphorylation) | SCF-isoform1(h) --> c-Kit(h){pY568}{pY936} (increase of phosphorylation) | SCF-isoform1(h) --> c-Cbl(h):c-Kit(h){pY568}{pY936} (increase of binding) | SCF-isoform1(h) --> c-Cbl(h):c-Kit(h) (increase of binding) | SCF-isoform1(h) --> c-Kit(h){p} (increase of phosphorylation) | SCF-isoform1(h) --> MITF(h){p} (increase of phosphorylation) | SCF-isoform1(h) --> CREB1(h){p} (increase of phosphorylation) | SCF-isoform1(h) --> ERK1(h){p} (increase of phosphorylation) | SCF-isoform1(h) --> ERK2(h){p} (increase of phosphorylation) | SCF-isoform1(h) --> AKT-1(h){pS473} (increase of phosphorylation) | SCF-isoform1(h) --> melanin (increase of abundance) | KITLG(h) --> SCF-isoform1(h) (expression). | KITLG(h) --> SCF-isoform2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 90 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 97 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 118 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 145 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 195 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr12 |
Promoter: 87497869 - 87499869 | Agilent_014791 |
chr12 |
Promoter: 87497869 - 87499869 | GSE27584 |
chr12 |
Promoter: 87497869 - 87499869 | GSE27584 |
chr12 |
Promoter: 87497869 - 87499869 | Agilent_014791_44K |