Entrez Gene

Basic Information
Gene ID	4208
Name	MEF2C
Synonymous	C5DELq14.3; DEL5q14.3;myocyte enhancer factor 2C;MEF2C;myocyte enhancer factor 2C
Definition	MADS box transcription enhancer factor 2, polypeptide C\|myocyte-specific enhancer factor 2C
Position	5q14
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
MEF2C(h) --> MEF-2C/delta8,32(h) (expression).
HDAC7(m.s.) + MEF-2C/delta8(h) <==> HDAC7(m.s.):MEF-2C/delta8(h) (binding)
MEF2C(h) --> MEF-2C/delta8(h) (expression).
MEF-2C(h) --Caspase-7(h)--> MEF-2C-CF1(h) + protein remnants (processing)
MEF-2C(h) + acetyl-CoA --p300(v.s.)--> MEF-2C(h){ace} + CoA (acetylation)
MEF-2C(h) + acetyl-CoA --> MEF-2C(h){ace} + CoA (acetylation)
MEF-2C(h) + acetyl-CoA --p300(h)--> MEF-2C(h){ace} + CoA (acetylation)
MEF-2C(h) + acetyl-CoA --p/CAF(h)--> MEF-2C(h){ace} + CoA (acetylation)
MEF-2C(h) + 6 acetyl-CoA --p300(v.s.)--> MEF-2C(h){aceK116}{aceK119}{aceK234}{aceK239}{aceK252}{aceK264} + 6 CoA (acetylation)
MEF-2C(h) --> CPT1B(h) (DNA binding; transactivation).
MEF-2C(h) --> BCMO1(h) (DNA binding; transactivation).
MEF2C(h) --> MEF-2C(h) (expression).
MEF2C(h) --> MEF-2C/delta32(h) (expression).
MEF-2C(h) + ATP --p38alpha(m)--> MEF-2C(h){p} + ADP (phosphorylation)
MEF-2C(h) + ATP --p38beta2(h)--> MEF-2C(h){p} + ADP (phosphorylation)
MEF-2C(h) --Caspase-7(h)--> MEF-2C-fragment(h) + protein remnants (processing)
MEF-2C(h) + SUMO2(h) --> MEF-2C(h){sumo2K391} (sumoylation)
p38alpha(m.s.) + MEF-2C(h) <==> p38alpha(m.s.):MEF-2C(h) (binding)
MEF2C(h) --> MEF-2C(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
59	Phosphoserine (by CK2) (By similarity).		Swiss-Prot 53.0
396	Phosphoserine.		Swiss-Prot 53.0
391	Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).		Swiss-Prot 53.0
293	Phosphothreonine (MAPK14)	9069290	Phospho.ELM 6.0
300	Phosphothreonine (MAPK14)	9069290	Phospho.ELM 6.0

Transcription Factors [Top]