| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 4194 |
Name | MDM4 |
Synonymous | HDMX|MDMX|MRP1;Mdm4 p53 binding protein homolog (mouse);MDM4;Mdm4 p53 binding protein homolog (mouse) |
Definition | MDM4-related protein 1|Mdm4, transformed 3T3 cell double minute 4, p53 binding protein|double minute 4, human homolog of; p53-binding protein|mdm2-like p53-binding protein|protein Mdm4|protein Mdmx |
Position | 1q32 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | p53(h) + Mdm4(h) <==> p53(h):Mdm4(h) (binding) | p73alpha(mo) + Mdm4(h) <==> p73alpha(mo):Mdm4(h) (binding) | CKI-alpha(h) + Mdm4(h) <==> CKI-alpha(h):Mdm4(h) (binding) | Mdm4(h) + 14-3-3tau(h) <==> Mdm4(h):14-3-3tau(h) (binding) | p53(m.s.) + Mdm4(h) <==> p53(m.s.):Mdm4(h) (binding) | Mdm4(h) + ATP --CKI-alpha(h)--> Mdm4(h){pS289} + ADP (phosphorylation) | Mdm4(h) --26S proteasome(h)--> protein remnants (degradation) | Mdm4(h) + ATP --> Mdm4(h){pS403} + ADP (phosphorylation) | mdm2(h) + Mdm4(h) <==> mdm2(h):Mdm4(h) (binding) | Mdm4(h) + ATP --Chk2(h)--> Mdm4(h){pS367} + ADP (phosphorylation) | Mdm4(h) + (14-3-3tau(m.s.))2 <==> Mdm4(h):(14-3-3tau(m.s.))2 (binding) | HAUSP(h) + Mdm4(h) <==> HAUSP(h):Mdm4(h) (binding) | Mdm4(h) + HAUSP(h) <==> Mdm4(h):HAUSP(h) (binding) | Mdm4(h) + 14-3-3gamma(h) <==> Mdm4(h):14-3-3gamma(h) (binding) | Mdm4(h) --> Mdm4(h) (translocation) | Mdm4(h) + ATP --Chk1(h)--> Mdm4(h){pS367} + ADP (phosphorylation) | MDM4(h) --> Mdm4(h) (expression). | p16INK4a-p14(h) --/ Mdm4(h) (decrease of abundance) | Mdm4(h) --> Mdm4(h) (translocation) | Mdm4(h) + 2 sumo1(m.s.) --> MDM4(h){sumoK254}{sumoK379} (sumoylation) | Mdm4(h) --> protein remnants (degradation) | Mdm4(h) + sumo1(m.s.) --Aos1(h):SAE2(h),Ubc9(m.s.)--> Mdm4(h){sumo} (sumoylation) | Mdm4(h) + ubiquitin(h) --mdm2(h)--> Mdm4(h){ub} (ubiquitination) | Mdm4(h) + n ubiquitin(h) --mdm2(h)--> Mdm4(h){ub}n (ubiquitination) | Mdm4(h) + ATP --ATM(h)--> Mdm4(h){pS403} + ADP (phosphorylation) | Mdm4(h) + ATP --> Mdm4(h){pS403} + ADP (phosphorylation) | Mdm4(h) + 3 ATP --> Mdm4(h){pS342}{pT365}{pS367} + 3 ADP (phosphorylation) | Mdm4(h) + mdm2(h) <==> Mdm4(h):mdm2(h) (binding) | Mdm4(h) --26S proteasome(h)--> protein remnants (degradation) | Mdm4(h) + ubiquitin(h) --> Mdm4(h){ub} (ubiquitination) | Mdm4(h) + n ubiquitin(h) --E1(rb),Ubc5B(h),mdm2-isoform1(h)--> Mdm4(h){ub}n (ubiquitination) | mdm2-isoform1(h) + Mdm4(h) <==> mdm2-isoform1(h):Mdm4(h) (binding) | Mdm4(h) + n ubiquitin(h) --mdm2-isoform1(h)--> Mdm4(h){ub}n (ubiquitination) | Mdm4(h) + 2 ATP --Chk2-isoform1(h)--> Mdm4(h){pS342}{pS367} + 2 ADP (phosphorylation) | Mdm4(h) --> Mdm4(h) (translocation) | Mdm4(h) + HAUSP(h) <==> Mdm4(h):HAUSP(h) (binding) | Mdm4(h) + n ubiquitin(h) --E1(m.s.),Ubc5A(m.s.),mdm2(m.s.)--> Mdm4(h){ub}n (ubiquitination) | 14-3-3gamma(h) + Mdm4(h) <==> 14-3-3gamma(h):Mdm4(h) (binding) | Mdm4(h) + 14-3-3gamma(h) <==> Mdm4(h):14-3-3gamma(h) (binding) | Mdm4(h) + ATP --Chk1(m.s.)--> Mdm4(h){pS367} + ADP (phosphorylation) | Mdm4(h) --/ p21Cip1(h) (decrease of abundance) | Mdm4(h) --/ p53(h) (decrease of abundance) | Mdm4(h) --> p53(m.s.){ub}n (increase of ubiquitination) | CKI-alpha(h) + Mdm4(h) <==> CKI-alpha(h):Mdm4(h) (binding) | Mdm4(h) + 14-3-3tau(h) <==> Mdm4(h):14-3-3tau(h) (binding) | 14-3-3gamma(m.s.) + Mdm4(h) <==> 14-3-3gamma(m.s.):Mdm4(h) (binding) | 14-3-3beta(m.s.) + Mdm4(h) <==> 14-3-3beta(m.s.):Mdm4(h) (binding) | Mdm4(h) + 14-3-3tau(h) <==> Mdm4(h):14-3-3tau(h) (binding) | Mdm4(h) + 14-3-3epsilon(m.s.) <==> Mdm4(h):14-3-3epsilon(m.s.) (binding) | Mdm4(h) + 14-3-3eta(m.s.) <==> Mdm4(h):14-3-3eta(m.s.) (binding) | Mdm4(h) + 14-3-3zeta(m.s.) <==> Mdm4(h):14-3-3zeta(m.s.) (binding) | Mdm4(h) --> Mdm4(h) (translocation) | importin-alpha3(m.s.) + Mdm4(h) <==> importin-alpha3(m.s.):Mdm4(h) (binding) | p53(h) + Mdm4(h) <==> p53(h):Mdm4(h) + p53(h):Mdm4(h) (binding) | MDM4(h) --> Mdm4(h) (expression). | Mdm4(h){sumo} --senp1(m.s.)--> Mdm4(h) + sumo1(m.s.) (desumoylation) | Mdm4(h) --> Mdm4(h) (translocation) | Mdm4(h){ub}n --HAUSP(h)--> Mdm4(h) + n ubiquitin(h) (deubiquitination) | Mdm4(h) --> Mdm4(h) (translocation) |
|---|
Post Translational Modification [Top] | |||
There is no record for MDM4 | |||
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr1 |
Promoter: 202750634 - 202752634 | Agilent_014791 |
chr1 |
Promoter: 202750634 - 202752634 | GSE27584 |
chr1 |
Promoter: 202750634 - 202752634 | Agilent_014791_44K |
chr1 |
Promoter: 202750634 - 202752634 | Agilent_014791 |