Entrez Gene

Basic Information
Gene ID	4137
Name	MAPT
Synonymous	DDPAC\|FTDP-17\|MAPTL\|MSTD\|MTBT1\|MTBT2\|PPND\|TAU;microtubule-associated protein tau;MAPT;microtubule-associated protein tau
Definition	G protein beta1/gamma2 subunit-interacting factor 1\|PHF-tau\|neurofibrillary tangle protein\|paired helical filament-tau
Position	17q21.1
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
GSK3beta(h) + PS1(h) + Tau(h) <==> GSK3beta(h):PS1(h):Tau(h) (binding)
Tau(h) --GSK3beta(h)--> Tau(h){p} (phosphorylation)
Tau(h) + ATP --Cdk1(h)--> Tau(h){pT231} + ADP (phosphorylation)
Tau(h) + ATP --p38alpha(x)--> Tau(h){p} + ADP (phosphorylation)
Tau(h) + NTP --p38beta1(h)--> Tau(h){p} + NDP (phosphorylation)
Tau(h) + NTP --p38gamma(r)--> Tau(h){p} + NDP (phosphorylation)
Tau(h) + NTP --p38delta(h)--> Tau(h){p} + NDP (phosphorylation)
Tau(h) + ATP --Cdk5(h):CDK5R1p25(h)--> Tau(h){p} + ADP (phosphorylation)
Tau(h) + 14-3-3zeta(h) <==> Tau(h):14-3-3zeta(h) (binding)
Tau(h) --calpain-2(r)--> protein remnants (processing)
Tau(h) + ATP --> Tau(h){pY18} + ADP (phosphorylation)
Fyn(m.s.) + Tau(h) <==> Fyn(m.s.):Tau(h) (binding)
Tau(h) + 2 ATP --> Tau(h){pS}{pT} + 2 ADP (phosphorylation)
Tau(h) + ATP --> Tau(h){pY} + ADP (phosphorylation)
Fyn(h) + Tau(h) <==> Fyn(h):Tau(h) (binding)
Tau(h) + 4 ATP --> Tau(h){pT181}{pT231}{pS396}{pS404} + 4 ADP (phosphorylation)
Tau(h) + Hsc70(h) <==> Tau(h):Hsc70(h) (binding)
Tau(h) + 2 ATP --> Tau(h){pS202}{pT205} + 2 ADP (phosphorylation)
Tau(h) + ATP --> Tau(h){pS} + ADP (phosphorylation)
Pin1(h):Tau(h){pT231} --PP2A(pg)--> Pin1(h) + Tau(h) + p (dephosphorylation; dissociation)
PP2A-ABalphaC(b):Tau(h){p} --> PP2A-ABalphaC(b) + Tau(h) + p (dephosphorylation; dissociation)
MAPT(h) --> Tau(h) (expression).
STAU1(h) --> Tau(h) (binding)
MAPT(h) --> PNS-tau(h) (expression).
MAPT(h) --> Fetal-tau(h) (expression).
Tau-A(h) + ATP --Fyn(m.s.)--> Tau-A(h){pY18} + ADP (phosphorylation)
Fyn(m.s.) + Tau-A(h) <==> Fyn(m.s.):Tau-A(h) (binding)
Lck(m.s.) + Tau-A(h) <==> Lck(m.s.):Tau-A(h) (binding)
Src(m.s.) + Tau-A(h) <==> Src(m.s.):Tau-A(h) (binding)
Tau-A(h) + ATP --> Tau-A(h){pY} + ADP (phosphorylation)
MAPT(h) --> Tau-A(h) (expression).
MAPT(h) --> Tau-B(h) (expression).
Tau-C(h) + 6 ATP --> Tau-C(h){pT205}{pT231}{pS202}{pS235}{pS396}{pS404} + 6 ADP (phosphorylation)
MAPT(h) --> Tau-C(h) (expression).
Fyn(m.s.) + Tau-D(h) <==> Fyn(m.s.):Tau-D(h) (binding)
MAPT(h) --> Tau-D(h) (expression).
MAPT(h) --> Tau-E(h) (expression).
ApoE3(h) + Tau-F(h) <==> ApoE3(h):Tau-F(h) (binding)
Tau-F(h) + ApoE-p22(h) <==> Tau-F(h):ApoE-p22(h) (binding)
Tau-F(h) + 2 ATP --Dyrk1A(m)--> Tau-F(h){pS202}{pS404} + 2 ADP (phosphorylation)
Tau-F(h) + 3 ATP --Dyrk1A(m)--> Tau-F(h){pS202}{pT212}{pS404} + 3 ADP (phosphorylation)
MAPT(h) --> Tau-F(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
2	N-acetylalanine.		Swiss-Prot 53.0
46	Phosphoserine; by PDPK.		Swiss-Prot 53.0
50	Phosphothreonine; by PDPK.		Swiss-Prot 53.0
87	N-linked (Glc) (glycation); in PHF-tau.		Swiss-Prot 53.0
111	Phosphothreonine (By similarity).		Swiss-Prot 53.0
383	N-linked (Glc) (glycation); in PHF-tau.		Swiss-Prot 53.0
467	N-linked (Glc) (glycation); in PHF-tau.		Swiss-Prot 53.0
470	Phosphothreonine; by PDPK.		Swiss-Prot 53.0
480	N-linked (Glc) (glycation); in PHF-tau.		Swiss-Prot 53.0
484	Deamidated asparagine; in tau and PHF-tau; partial.		Swiss-Prot 53.0
491	N-linked (Glc) (glycation); in PHF-tau.		Swiss-Prot 53.0
492	Phosphothreonine; by PDPK.		Swiss-Prot 53.0
498	Phosphothreonine; by PDPK.		Swiss-Prot 53.0
514	Phosphotyrosine (By similarity).		Swiss-Prot 53.0
515	Phosphoserine; by PDPK.		Swiss-Prot 53.0
516	Phosphoserine; by PDPK.		Swiss-Prot 53.0
519	Phosphoserine; by PDPK.		Swiss-Prot 53.0
522	Phosphothreonine; by PDPK.		Swiss-Prot 53.0
529	Phosphothreonine; by PDPK.		Swiss-Prot 53.0
531	Phosphoserine; by PKA.		Swiss-Prot 53.0
534	Phosphothreonine; by PDPK.		Swiss-Prot 53.0
542	N-linked (Glc) (glycation); in PHF-tau.		Swiss-Prot 53.0
548	Phosphothreonine; by PDPK.		Swiss-Prot 53.0
551	N-linked (Glc) (glycation); in PHF-tau.		Swiss-Prot 53.0
552	Phosphoserine; by PDPK.		Swiss-Prot 53.0
554	Phosphoserine; in PHF-tau.		Swiss-Prot 53.0
576	N-linked (Glc) (glycation); in PHF-tau.		Swiss-Prot 53.0
579	Phosphoserine; by MARK1.		Swiss-Prot 53.0
596	Deamidated asparagine; in tau and PHF-tau; partial.		Swiss-Prot 53.0
597	N-linked (Glc) (glycation); in PHF-tau.		Swiss-Prot 53.0
598	N-linked (Glc) (glycation); in PHF-tau.		Swiss-Prot 53.0
610	Phosphoserine; by MARK1; in PHF-tau.		Swiss-Prot 53.0
622	Phosphoserine; by MARK1; in PHF-tau.		Swiss-Prot 53.0
641	Phosphoserine; by MARK1; in PHF-tau.		Swiss-Prot 53.0
664	N-linked (Glc) (glycation); in PHF-tau.		Swiss-Prot 53.0
670	N-linked (Glc) (glycation); in PHF-tau.		Swiss-Prot 53.0
673	Phosphoserine; by MARK1; in PHF-tau.		Swiss-Prot 53.0
686	N-linked (Glc) (glycation); in PHF-tau.		Swiss-Prot 53.0
713	Phosphoserine; by PDPK.		Swiss-Prot 53.0
717	Phosphoserine (By similarity).		Swiss-Prot 53.0
720	Phosphothreonine.		Swiss-Prot 53.0
721	Phosphoserine; by PDPK.		Swiss-Prot 53.0
726	Phosphoserine (By similarity).		Swiss-Prot 53.0
729	Phosphoserine (By similarity).		Swiss-Prot 53.0
731	Phosphothreonine (By similarity).		Swiss-Prot 53.0
733	Phosphoserine; by CaMK2.		Swiss-Prot 53.0
739	Phosphoserine; by PDPK.		Swiss-Prot 53.0
571	Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin) (inPHF-tau).		Swiss-Prot 53.0
628	Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin) (inPHF-tau).		Swiss-Prot 53.0
670	Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin) (inPHF-tau).		Swiss-Prot 53.0
574	Phosphoserine (GSK-3beta)	12714590	Phospho.ELM 6.0
578	Phosphoserine (GSK-3beta)	12714590	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr17	Promoter: 41326124 - 41328124	Agilent_014791
chr17	Promoter: 41326124 - 41328124	GSE27584
chr17	Promoter: 41326124 - 41328124	GSE27584
chr17	Promoter: 41326124 - 41328124	GSE27584
chr17	Promoter: 41326124 - 41328124	GSE27584
chr17	Promoter: 41326124 - 41328124	Agilent_014791_44K

Transcription Factors [Top]

Post Translational Modification [Top]

Methylation Profile [Top]