| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 4035 |
Name | LRP1 |
Synonymous | A2MR|APOER|APR|CD91|IGFBP3R|LRP|TGFBR5;low density lipoprotein receptor-related protein 1;LRP1;low density lipoprotein receptor-related protein 1 |
Definition | LRP-1|TbetaR-V/LRP-1/IGFBP-3 receptor|alpha-2-macroglobulin receptor|apolipoprotein E receptor|prolow-density lipoprotein receptor-related protein 1|type V tgf-beta receptor |
Position | 12q13-q14 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | C4BP(h) + CD91(h) <==> C4BP(h):CD91(h) (binding) | C4BPalpha(h) + CD91(h) <==> C4BPalpha(h):CD91(h) (binding) | APP(h) + CD91(h) <==> APP(h):CD91(h) (binding) | APP695(h) + CD91(h) <==> APP695(h):CD91(h) (binding) | CD91(h) + PKCalpha(h) <==> CD91(h):PKCalpha(h) (binding) | CD91(h) + ATP --PKCalpha(h)--> CD91(h){pT16}{pS73}{pS76}{pS79} + ADP (phosphorylation) | Dab1(m.s.) + CD91(h) <==> Dab1(m.s.):CD91(h) (binding) | GULP1(m.s.) + CD91(h) <==> GULP1(m.s.):CD91(h) (binding) | CD91(h) + proHNP3(h) <==> CD91(h):proHNP3(h) (increase of internalization; binding) | CD91(h) + Lipc(r) <==> CD91(h):Lipc(r) (increase of internalization; binding; destabilization) | c-Cbl(ha) + CD91(h) <==> c-Cbl(ha):CD91(h) (binding) | beta2-integrin(h) + CD91(h) <==> beta2-integrin(h):CD91(h) (binding) | CD11B(h) + CD91(h) <==> CD11B(h):CD91(h) (binding) | LRP1(h) --> CD91(h) (expression). | CD91(h) + beta2-integrin(h) <==> CD91(h):beta2-integrin(h) (binding) | CD11B(h) + CD91(h) <==> CD11B(h):CD91(h) (binding) | alphaL-integrin(h) + CD91(h) <==> alphaL-integrin(h):CD91(h) (binding) | CD11C(h) + CD91(h) <==> CD11C(h):CD91(h) (binding) | CD11B(h):beta2-integrin(h) + CD91(h) <==> CD11B(h):beta2-integrin(h):CD91(h) (binding) | LRP1(h) --> CD91(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 114 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 136 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 185 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 239 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 274 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 357 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 446 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 729 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 928 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1050 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1154 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1155 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1195 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1218 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1511 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1558 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1575 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1616 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1645 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1723 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1733 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1763 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1825 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1933 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1995 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 2048 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 2117 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 2127 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 2472 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 2502 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 2521 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 2539 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 2601 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 2620 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 2638 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 2815 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 2905 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 3048 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 3089 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 3264 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 3333 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 3488 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 3662 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 3788 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 3839 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 3953 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 4075 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 4125 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 4179 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 4278 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 4279 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 4364 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 4507 | Phosphotyrosine (Src) | 12789267 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr12 |
Promoter: 55807049 - 55809049 | Agilent_014791 |
chr12 |
Promoter: 55807049 - 55809049 | GSE27584 |
chr12 |
Promoter: 55807049 - 55809049 | Agilent_014791_44K |