| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 3485 |
Name | IGFBP2 |
Synonymous | IBP2|IGF-BP53;insulin-like growth factor binding protein 2, 36kDa;IGFBP2;insulin-like growth factor binding protein 2, 36kDa |
Definition | IBP-2|IGF-binding protein 2|IGFBP-2|insulin-like growth factor-binding protein 2 |
Position | 2q33-q34 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | IGF-1(h) + IGFBP-2(h) <==> IGF-1(h):IGFBP-2(h) (binding) | IGF-1(m.s.) + IGFBP-2(h) <==> IGF-1(m.s.):IGFBP-2(h) (binding) | IGF-2(m.s.) + IGFBP-2(h) <==> IGF-2(m.s.):IGFBP-2(h) (binding) | IGFBP-2(h) --> FAK(h){pY} (decrease of phosphorylation) | IGFBP-2(h) --> MAPK(h){p} (decrease of phosphorylation) | IGF-2(h) + IGFBP-2(h) <==> IGF-2(h):IGFBP-2(h) (binding) | IGF-2(h) + IGFBP-2(h) <==> IGF-2(h):IGFBP-2(h) (binding) | IGFBP-2(h) --> ERK1(h){pT}{pY} (increase of phosphorylation) | IGFBP-2(h) --> ERK2(h){pT}{pY} (increase of phosphorylation) | IGFBP-2(h) --> Raf(h){p} (increase of phosphorylation) | IGFBP-2(h) --> MEK1(h){p} (increase of phosphorylation) | IGFBP-2(h) --> MEK2(h){p} (increase of phosphorylation) | IGFBP-2(h) --> JNK1(h){p} (increase of phosphorylation) | IGFBP-2(h) --> JNK2(h){p} (increase of phosphorylation) | IGFBP-2(h) --> MKK4(h){p} (increase of phosphorylation) | IGFBP-2(h) --> p38(h){pT}{pY} (increase of phosphorylation) | IGFBP-2(h) --> Elk-1(h){p} (increase of phosphorylation) | IGFBP-2(h) --> c-Jun(h){p} (increase of phosphorylation) | IGFBP-2(h) --> ATF-2(h){p} (increase of phosphorylation) | IGFBP-2(h) --> FGF-6(h) (increase of abundance) | IGFBP-2(h) --> FGF-7(h) (increase of abundance) | IGFBP-2(h) --> NT-5(h) (increase of abundance) | IGFBP-2(h) --> PARC(h) (increase of abundance) | IGFBP-2(h) --> PlGF(h) (increase of abundance) | IGFBP-2(h) + IIP45(h) <==> IGFBP-2(h):IIP45(h) (binding) | IGFBP-2(h) --> TP53(h) (transactivation) | IGFBP-2(h) --> TGFB1(h) (transactivation) | IGFBP-2(h) --> BCL2(h) (transactivation) | IGFBP-2(h) --> LAMB1(h) (transactivation) | IGFBP-2(h) --> p53(h) (increase of abundance) | IGFBP-2(h) --> TGFbeta1(h) (increase of abundance) | IGFBP-2(h) --> NF-kappaB1-isoform1(h) (increase of abundance) | IGFBP-2(h) + vitronectin(h) <==> IGFBP-2(h):vitronectin(h) (binding) | IGFBP-2(h) + fibronectin(m.s.) <==> IGFBP-2(h):fibronectin(m.s.) (binding) | IGFBP-2(h) + laminin(m) <==> IGFBP-2(h):laminin(m) (binding) | IGFBP-2(h) + collagen-IV(b) <==> IGFBP-2(h):collagen-IV(b) (binding) | IGFBP-2(h) --kallikrein-2(h)--> IGFBP2-p14(h) + protein remnants (cleavage) | IGFBP-2(h) --kallikrein-2(h)--> IGFBP2-p20(h) + protein remnants (cleavage) | OPN(h) + IGFBP-2(h) <==> OPN(h):IGFBP-2(h) (binding) | IGFBP2(h) --> IGFBP-2(h) (expression). | IGF-2(h) + IGFBP-2(h) <==> IGF-2(h):IGFBP-2(h) (binding) | IGF-1(h) + IGFBP-2(h) <==> IGF-1(h):IGFBP-2(h) (binding) | IGFBP-2(h) --> FAK(h){pY} (decrease of phosphorylation) | IGFBP-2(h) + IIP45(h) <==> IGFBP-2(h):IIP45(h) (binding) | IGFBP-2(h) --plasminogen(m.s.)--> protein remnants (degradation) | IGFBP-2(h) --plasmin(m.s.)--> protein remnants (degradation) | IGFBP-2(h) --> IGFBP2-p22(h) + protein remnants (cleavage) | IGFBP-2(h) --> IGFBP2-p14(h) + protein remnants (cleavage) | IGFBP2(h) --> IGFBP-2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
There is no record for IGFBP2 | |||
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr2 |
Promoter: 217204872 - 217206872 | Agilent_014791 |
chr2 |
Promoter: 217204872 - 217206872 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 217204872 - 217206872 | GSE27584 |
chr2 |
Promoter: 217204872 - 217206872 | Agilent_014791_44K |
chr2 |
Promoter: 217204872 - 217206872 | Agilent_014791 |
chr2 |
Promoter: 217204872 - 217206872 | PMID:15911243 |